ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hgs

Full Name:

HGF-regulated tyrosine kinase substrate

Alias:

Hgr|Hrs|ZFYVE8

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 E2|11 75.0 cM

Physical Location:

120329004-120345292 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9146 Symbol (Name): HGS (hepatocyte growth factor-regulated tyrosine kinase substrate)

Ortholog Status:

The human GeneID 9146 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hgs
Original ID2:		D50050

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008244.2	NP_032270.2	NC_000077.5 range: 120329004..120345292

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (7565774)
GO:0005768	endosome	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0008270	zinc ion binding	Molecular Function	RCA (12466851)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	RCA (12466851)
GO:0015031	protein transport	Biological Process	IEA