ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PSCD1

Full Name:

pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1)

Alias:

B2-1|CYTOHESIN-1|D17S811E|FLJ34050|FLJ41900|SEC7

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25

Physical Location:

74181724-74289970 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 35425 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.191215
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IDA (12606567)
GO:0005886	plasma membrane	Cellular Component	IDA (12606567)
GO:0005086	ARF guanyl-nucleotide exchange factor activity	Molecular Function	TAS (9050849)
GO:0005515	protein binding	Molecular Function	IPI (11867758)
GO:0016192	vesicle-mediated transport	Biological Process	TAS (1511013)
GO:0030155	regulation of cell adhesion	Biological Process	IDA (12606567)
GO:0032012	regulation of ARF protein signal transduction	Biological Process	IEA