ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ATP6V1F

Full Name:

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F

Alias:

ATP6S14|MGC117321|MGC126037|MGC126038|VATF|Vma7

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7q32

Physical Location:

128290133-128293137 on NC_000007.12

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.78089
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004231.2	NP_004222.2	NC_000007.12 range: 128290133..128293137

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	TAS (8621738)
GO:0016469	proton-transporting two-sector ATPase complex	Cellular Component	TAS (8581736)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	Molecular Function	IEA
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0015992	proton transport	Biological Process	TAS (8581736)
GO:0046034	ATP metabolic process	Biological Process	IEA