ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pcdhgc3

Full Name:

protocadherin gamma subfamily C, 3

Alias:

MGC106426|PC43|Pcdh2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 B3

Physical Location:

37966063-38001526 on NC_000084.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5098 Symbol (Name): PCDHGC3 (protocadherin gamma subfamily C, 3)

Ortholog Status:

The human GeneID 5098 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pcdhgc3
Original ID2:		AI854522

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
-	-	NC_000084.5 range: 37966063..38001526

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	IDA (15347688)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (8575755)
GO:0005911	intercellular junction	Cellular Component	TAS (8575755)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0007156	homophilic cell adhesion	Biological Process	TAS (8575755)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0016339	calcium-dependent cell-cell adhesion	Biological Process	TAS (8575755)