ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GRHPR

Full Name:

glyoxylate reductase/hydroxypyruvate reductase

Alias:

GLXR|PH2

Organism:

Homo sapiens (Human)

Chromosome:

9

Genetic Location:

9q12

Physical Location:

37412706-37426985 on NC_000009.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.155742
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012203.1	NP_036335.1	NC_000009.10 range: 37412706..37426985

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005737	cytoplasm	Cellular Component	IDA (11256614)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0051287	NAD binding	Molecular Function	TAS (10484776)
GO:0051287	NAD binding	Molecular Function	IEA
GO:0048037	cofactor binding	Molecular Function	IEA
GO:0030267	glyoxylate reductase (NADP) activity	Molecular Function	NAS (10524214)
GO:0030267	glyoxylate reductase (NADP) activity	Molecular Function	IDA (10484776)
GO:0016618	hydroxypyruvate reductase activity	Molecular Function	IDA (10484776)
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0008465	glycerate dehydrogenase activity	Molecular Function	IDA (10484776)
GO:0005515	protein binding	Molecular Function	IPI (15231747)
GO:0008152	metabolic process	Biological Process	IEA
GO:0007588	excretion	Biological Process	IMP (10484776)
GO:0055114	oxidation reduction	Biological Process	IDA (10484776)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000137106

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: