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Gene Information
Gene ID:94167
Full Name:peroxiredoxin 6
Organism:Rattus norvegicus (Rat)
Genetic Location:13q22
Physical Location:76824433-76835530 on NC_005112.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9588    Symbol (Name): PRDX6 (peroxiredoxin 6)
Ortholog Status:The human GeneID 9588 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Prdx6
Fold Change:1.19
P Value:0.001
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Prdx6
Fold Change:1.15
P Value:0.005
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053576.2NP_446028.1NC_005112.2 range: 76824433..76835530, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005764lysosomeCellular ComponentIEA
GO:0005829cytosolCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0051920peroxiredoxin activityMolecular FunctionIEA
GO:0004623phospholipase A2 activityMolecular FunctionISS
GO:0004623phospholipase A2 activityMolecular FunctionIEA
GO:0004602glutathione peroxidase activityMolecular FunctionIDA (8641418)
GO:0004601peroxidase activityMolecular FunctionISS
GO:0042744hydrogen peroxide catabolic processBiological ProcessIDA (8641418)
GO:0016042lipid catabolic processBiological ProcessIEA
GO:0009395phospholipid catabolic processBiological ProcessISS
GO:0009395phospholipid catabolic processBiological ProcessIEA
GO:0006979response to oxidative stressBiological ProcessISS
GO:0006979response to oxidative stressBiological ProcessIEA
GO:0000302response to reactive oxygen speciesBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:94167