ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Prdx6

Full Name:

peroxiredoxin 6

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q22

Physical Location:

76824433-76835530 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9588 Symbol (Name): PRDX6 (peroxiredoxin 6)

Ortholog Status:

The human GeneID 9588 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Prdx6
Fold Change:		1.19
P Value:		0.001
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Prdx6
Fold Change:		1.15
P Value:		0.005
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053576.2	NP_446028.1	NC_005112.2 range: 76824433..76835530, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005764	lysosome	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0051920	peroxiredoxin activity	Molecular Function	IEA
GO:0004623	phospholipase A2 activity	Molecular Function	ISS
GO:0004623	phospholipase A2 activity	Molecular Function	IEA
GO:0004602	glutathione peroxidase activity	Molecular Function	IDA (8641418)
GO:0004601	peroxidase activity	Molecular Function	ISS
GO:0042744	hydrogen peroxide catabolic process	Biological Process	IDA (8641418)
GO:0016042	lipid catabolic process	Biological Process	IEA
GO:0009395	phospholipid catabolic process	Biological Process	ISS
GO:0009395	phospholipid catabolic process	Biological Process	IEA
GO:0006979	response to oxidative stress	Biological Process	ISS
GO:0006979	response to oxidative stress	Biological Process	IEA
GO:0000302	response to reactive oxygen species	Biological Process	ISS