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Gene Information
Gene ID:94188
Full Name:zinc finger protein 423
Organism:Rattus norvegicus (Rat)
Genetic Location:19p11
Physical Location:20475866-20739237 on NC_005118.2
Gene Type:protein-coding
Human Ortholog:GeneID: 23090    Symbol (Name): ZNF423 (zinc finger protein 423)
Ortholog Status:The human GeneID 23090 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Zfp423
Fold Change:1.2
P Value:0.002
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053583.1NP_446035.1NC_005118.2 range: 20475866..20739237
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS
GO:0003677DNA bindingMolecular FunctionIEA
GO:0016564transcription repressor activityMolecular FunctionISS
GO:0016563transcription activator activityMolecular FunctionISS
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIPI (9774661)
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0016481negative regulation of transcriptionBiological ProcessISS
GO:0006350transcriptionBiological ProcessIEA
GO:0030154cell differentiationBiological ProcessIEA
GO:0045941positive regulation of transcriptionBiological ProcessISS
GO:0007399nervous system developmentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:94188