ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Zfp423

Full Name:

zinc finger protein 423

Alias:

Roaz

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

19p11

Physical Location:

20475866-20739237 on NC_005118.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23090 Symbol (Name): ZNF423 (zinc finger protein 423)

Ortholog Status:

The human GeneID 23090 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Zfp423
Fold Change:		1.2
P Value:		0.002
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053583.1	NP_446035.1	NC_005118.2 range: 20475866..20739237

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0016563	transcription activator activity	Molecular Function	ISS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IPI (9774661)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0016481	negative regulation of transcription	Biological Process	ISS
GO:0006350	transcription	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0045941	positive regulation of transcription	Biological Process	ISS
GO:0007399	nervous system development	Biological Process	IEA