ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Spock2

Full Name:

sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2

Alias:

AA407235|Gcap26|mKIAA0275

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 B3

Physical Location:

59569004-59596661 on NC_000076.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9806 Symbol (Name): SPOCK2 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2)

Ortholog Status:

The human GeneID 9806 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Spock2
Original ID2:		AI844853

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_052994.2	NP_443720.1	NC_000076.5 range: 59569004..59596661

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005509	calcium ion binding	Molecular Function	ISS (10386950)