ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SCARB1

Full Name:

scavenger receptor class B, member 1

Alias:

CD36L1|CLA-1|CLA1|MGC138242|SR-BI|SRB1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12q24.31

Physical Location:

123828126-123914471 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 25073 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S324

125191039

Region:		123191039-127191039
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	TAS (7689561)
GO:0005624	membrane fraction	Cellular Component	NR
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12039952)
GO:0005215	transporter activity	Molecular Function	TAS (9211901)
GO:0004872	receptor activity	Molecular Function	TAS (9211901)
GO:0006915	apoptosis	Biological Process	NR
GO:0007155	cell adhesion	Biological Process	IEA
GO:0008203	cholesterol metabolic process	Biological Process	TAS (9211901)
GO:0006810	transport	Biological Process	TAS (9211901)