ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

25073

Symbol:

Scarb1

Full Name:

scavenger receptor class B, member 1

Alias:

Cd36l1|SR-B1|Srb1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

12q15-q16

Physical Location:

32390182-32457660 on NC_005111.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 949 Symbol (Name): SCARB1 (scavenger receptor class B, member 1)

Ortholog Status:

The human GeneID 949 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		25073
Fold Change:		0.691
P Value:		0.033
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031541.1	NP_113729.1	NC_005111.2 range: 32390182..32457660

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000299	integral to membrane of membrane fraction	Cellular Component	ISS
GO:0009986	cell surface	Cellular Component	IDA (11882321)
GO:0016020	membrane	Cellular Component	IEA
GO:0031528	microvillus membrane	Cellular Component	IMP (14657200)
GO:0005901	caveola	Cellular Component	ISS
GO:0005887	integral to plasma membrane	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IDA (11882321)
GO:0005515	protein binding	Molecular Function	ISS
GO:0005319	lipid transporter activity	Molecular Function	TAS (9177301\|9421400\|10026214\|12016218\|12746305)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0001786	phosphatidylserine binding	Molecular Function	TAS (10026214)
GO:0001786	phosphatidylserine binding	Molecular Function	IDA (12016218)
GO:0008035	high-density lipoprotein binding	Molecular Function	ISS
GO:0043534	blood vessel endothelial cell migration	Biological Process	ISS
GO:0050764	regulation of phagocytosis	Biological Process	IDA (12016218)
GO:0030301	cholesterol transport	Biological Process	ISS
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006910	phagocytosis, recognition	Biological Process	IMP (12016218)
GO:0006869	lipid transport	Biological Process	IMP (12032160)
GO:0006707	cholesterol catabolic process	Biological Process	ISS
GO:0006702	androgen biosynthetic process	Biological Process	IDA (12746305)
GO:0006694	steroid biosynthetic process	Biological Process	TAS (9421400\|10026214\|12016218\|12746305)
GO:0001935	endothelial cell proliferation	Biological Process	ISS
GO:0050764	regulation of phagocytosis	Biological Process	TAS (10026214)