ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CLOCK

Full Name:

clock homolog (mouse)

Alias:

KAT13D|KIAA0334

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q12

Physical Location:

55993416-56107753 on NC_000004.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 60447 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CLOCK

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Information

Original ID1:

CLOCK

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004898.2	NP_004889.1	NC_000004.10 range: 55993416..56107753, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005667	transcription factor complex	Cellular Component	IPI (9576906)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0004402	histone acetyltransferase activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	TAS (10198158)
GO:0008415	acyltransferase activity	Molecular Function	IEA
GO:0009648	photoperiodism	Biological Process	TAS (10198158)
GO:0007623	circadian rhythm	Biological Process	TAS (10198158)
GO:0007165	signal transduction	Biological Process	TAS (10198158)
GO:0007165	signal transduction	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (9576906)