ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CARTPT

Full Name:

CART prepropeptide

Alias:

CART

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q13.2

Physical Location:

71050749-71052627 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CART

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Information

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D5S647

66282906

Region:		66282906-76193808
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004291.2	NP_004282.1	NC_000005.8 range: 71050749..71052627

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	ISS
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IDA (11711504)
GO:0005515	protein binding	Molecular Function	IEA
GO:0032812	positive regulation of epinephrine secretion	Biological Process	IDA (11711504)
GO:0032922	circadian regulation of gene expression	Biological Process	ISS
GO:0045671	negative regulation of osteoclast differentiation	Biological Process	TAS (16614075)
GO:0045777	positive regulation of blood pressure	Biological Process	IDA (11711504)
GO:0000186	activation of MAPKK activity	Biological Process	ISS (15908120)
GO:0045779	negative regulation of bone resorption	Biological Process	IMP (16614075)
GO:0032099	negative regulation of appetite	Biological Process	TAS (11478874)
GO:0032099	negative regulation of appetite	Biological Process	ISS
GO:0009267	cellular response to starvation	Biological Process	ISS (15680948)
GO:0008343	adult feeding behavior	Biological Process	ISS
GO:0007268	synaptic transmission	Biological Process	IEA
GO:0007218	neuropeptide signaling pathway	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	TAS (8647455)
GO:0001678	cellular glucose homeostasis	Biological Process	IDA (11711504)
GO:0051971	positive regulation of transmission of nerve impulse	Biological Process	IDA (11711504)