ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hmgb2

Full Name:

high mobility group box 2

Alias:

C80539|HMG-2|Hmg2|MGC103184

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 B2

Physical Location:

59990672-59993283 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3148 Symbol (Name): HMGB2 (high-mobility group box 2)

Ortholog Status:

The human GeneID 3148 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X67668
Fold Change:		1.9, 2.5, 4.9, 3.2
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws3/Alcw6	Chronic Alcohol Withdrawal	8		16-43 (cM)	3.5	0.0003	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008252.2	NP_032278.1	NC_000074.5 range: 59990672..59993283

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000785	chromatin	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005694	chromosome	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA