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Browse all tumor suppressor genes by chromosome
Allows users to browse all tumor suppressor genes by chromosomes. Result shows a list of genes.

Browse 73 tumor suppressor genes with potential oncogenic role
73 TSGs with potential oncogeneic role.
Browse all down-regulated tumor suppressor genes in tumor versus normal samples
BLCA : 493 human TSGs that have lower expression in bladder urothelial carcinoma samples compared to the normal tissue samples in TCGA.
BRCA : 589 human TSGs that have lower expression in breast invasive carcinoma samples compared to the normal tissue samples in TCGA.
COAD : 535 human TSGs that have lower expression in colon adenocarcinoma samples compared to the normal tissue samples in TCGA.
HNSC : 445 human TSGs that have lower expression in head and neck squamous cell carcinoma samples compared to the normal tissue samples in TCGA.
KICH : 568 human TSGs that have lower expression in kidney chromophobe samples compared to the normal tissue samples in TCGA.
KIRC : 491 human TSGs that have lower expression in kidney renal clear cell carcinoma samples compared to the normal tissue samples in TCGA.
LUAD : 525 human TSGs that have lower expression in lung adenocarcinoma samples compared to the normal tissue samples in TCGA.
LUSC : 534 human TSGs that have lower expression in lung squamous cell carcinoma samples compared to the normal tissue samples in TCGA.
PRAD : 564 human TSGs that have lower expression in prostate adenocarcinoma samples compared to the normal tissue samples in TCGA.
THCA : 486 human TSGs that have lower expression in thyroid carcinoma samples compared to the normal tissue samples in TCGA.
UCEC : 526 human TSGs that have lower expression in uterine corpus endometrial carcinoma samples compared to the normal tissue samples in TCGA.
Browse all tumor suppressor genes by the ratio of the loss-of-function mutations over missense mutations
24 human TSGs with the ratio being greater or equal to 0.5, indicating more loss-of-function mutations in those genes.
52 human TSGs with the ratio between 0.3 and 0.5.
97 human TSGs with the ratio between 0.2 and 0.3.
709 human TSGs with the ratio greater than 0 and less than 0.2.
118 human TSGs with the ratio being equal to 0, which means have more missence mutations.
Browse all tumor suppressor genes by gene type
All the human protein-coding TSGs.
All the human non-coding TSGs.
Browse all tumor suppressor genes by major cancer types based on curated literature
Breast cancer
Prostate cancer
Rectal cancer
Colon cancer
Ovarian cancer
Small cell lung cancer
Melanoma
Non-small cell lung cancer
Retinoblastoma
Lymphomas
Pancreatic cancer
Leukemias
Cervical cancer
Brain tumor
Acute myeloid leukemia
Neuroblastoma
Nasopharyngeal carcinoma
Thyroid cancer
Bladder cancer
Head and neck cancer
Esophageal cancer
Hodgkin lymphoma
Pheochromocytoma
Non-Hodgkin lymphoma
Chronic lymphocytic leukemia
Endometrial cancer
Oral cancer
Chronic myelogenous leukemia
Pituitary adenoma
Gallbladder cancer
Basal cell carcinoma
Soft tissue sarcoma
Testicular cancer
Liposarcoma
Primary central nervous system lymphoma
Myelodysplastic syndromes
Laryngeal cancer
Kaposi sarcoma
Ependymoma
Burkitt lymphoma
Uterine sarcoma
Stomach cancer
Pharyngeal cancer
Parathyroid cancer
Mycosis fungoides
Merkel cell carcinoma
Extrahepatic bile duct cancer
Cutaneous T-cell lymphoma
Childhood cancers
Anal cancer
AIDS-related lymphoma
AIDS-related cancers
Adrenocortical carcinoma
Browse all tumor suppressor genes by KEGG pathway chart
hsa05206 MicroRNAs in cancer - Homo sapiens (human), 155 genes
hsa05200 Pathways in cancer - Homo sapiens (human), 95 genes
hsa05166 HTLV-I infection - Homo sapiens (human), 46 genes
hsa01100 Metabolic pathways - Homo sapiens (human), 45 genes
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human), 42 genes
hsa05205 Proteoglycans in cancer - Homo sapiens (human), 41 genes
hsa04390 Hippo signaling pathway - Homo sapiens (human), 40 genes
hsa04068 FoxO signaling pathway - Homo sapiens (human), 40 genes
hsa05161 Hepatitis B - Homo sapiens (human), 37 genes
hsa04110 Cell cycle - Homo sapiens (human), 35 genes
hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human), 35 genes
hsa05203 Viral carcinogenesis - Homo sapiens (human), 33 genes
hsa04010 MAPK signaling pathway - Homo sapiens (human), 33 genes
hsa04115 P53 signaling pathway - Homo sapiens (human), 33 genes
hsa04310 Wnt signaling pathway - Homo sapiens (human), 31 genes
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), 30 genes
hsa04360 Axon guidance - Homo sapiens (human), 28 genes
hsa04014 Ras signaling pathway - Homo sapiens (human), 27 genes
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human), 27 genes
hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human), 26 genes
hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human), 25 genes
hsa05168 Herpes simplex infection - Homo sapiens (human), 25 genes
hsa05169 Epstein-Barr virus infection - Homo sapiens (human), 24 genes
hsa05160 Hepatitis C - Homo sapiens (human), 24 genes
hsa04350 TGF-beta signaling pathway - Homo sapiens (human), 23 genes
hsa05215 Prostate cancer - Homo sapiens (human), 23 genes
hsa04510 Focal adhesion - Homo sapiens (human), 23 genes
hsa04015 Rap1 signaling pathway - Homo sapiens (human), 22 genes
hsa05162 Measles - Homo sapiens (human), 22 genes
hsa05220 Chronic myeloid leukemia - Homo sapiens (human), 22 genes
hsa05212 Pancreatic cancer - Homo sapiens (human), 22 genes
hsa04152 AMPK signaling pathway - Homo sapiens (human), 21 genes
hsa05164 Influenza A - Homo sapiens (human), 21 genes
hsa04380 Osteoclast differentiation - Homo sapiens (human), 20 genes
hsa05222 Small cell lung cancer - Homo sapiens (human), 20 genes
hsa04024 cAMP signaling pathway - Homo sapiens (human), 20 genes
hsa05152 Tuberculosis - Homo sapiens (human), 20 genes
hsa04722 Neurotrophin signaling pathway - Homo sapiens (human), 20 genes
hsa04071 Sphingolipid signaling pathway - Homo sapiens (human), 19 genes
hsa04144 Endocytosis - Homo sapiens (human), 19 genes
hsa04530 Tight junction - Homo sapiens (human), 19 genes
hsa05210 Colorectal cancer - Homo sapiens (human), 18 genes
hsa04062 Chemokine signaling pathway - Homo sapiens (human), 18 genes
hsa04660 T cell receptor signaling pathway - Homo sapiens (human), 18 genes
hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human), 18 genes
hsa04910 Insulin signaling pathway - Homo sapiens (human), 17 genes
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human), 17 genes
hsa04728 Dopaminergic synapse - Homo sapiens (human), 17 genes
hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human), 17 genes
hsa05223 Non-small cell lung cancer - Homo sapiens (human), 16 genes
hsa05213 Endometrial cancer - Homo sapiens (human), 16 genes
hsa05219 Bladder cancer - Homo sapiens (human), 16 genes
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human), 15 genes
hsa04917 Prolactin signaling pathway - Homo sapiens (human), 15 genes
hsa05211 Renal cell carcinoma - Homo sapiens (human), 15 genes
hsa04210 Apoptosis - Homo sapiens (human), 15 genes
hsa04668 TNF signaling pathway - Homo sapiens (human), 15 genes
hsa05016 Huntington's disease - Homo sapiens (human), 15 genes
hsa04066 HIF-1 signaling pathway - Homo sapiens (human), 15 genes
hsa05217 Basal cell carcinoma - Homo sapiens (human), 15 genes
hsa04150 mTOR signaling pathway - Homo sapiens (human), 14 genes
hsa05221 Acute myeloid leukemia - Homo sapiens (human), 14 genes
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human), 14 genes
hsa04520 Adherens junction - Homo sapiens (human), 14 genes
hsa04670 Leukocyte transendothelial migration - Homo sapiens (human), 14 genes
hsa04662 B cell receptor signaling pathway - Homo sapiens (human), 14 genes
hsa04114 Oocyte meiosis - Homo sapiens (human), 14 genes
hsa01130 Biosynthesis of antibiotics - Homo sapiens (human), 14 genes
hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human), 14 genes
hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human), 13 genes
hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human), 13 genes
hsa04012 ErbB signaling pathway - Homo sapiens (human), 13 genes
hsa05218 Melanoma - Homo sapiens (human), 13 genes
hsa05214 Glioma - Homo sapiens (human), 13 genes
hsa04064 NF-kappa B signaling pathway - Homo sapiens (human), 13 genes
hsa03460 Fanconi anemia pathway - Homo sapiens (human), 13 genes
hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human), 13 genes
hsa04921 Oxytocin signaling pathway - Homo sapiens (human), 12 genes
hsa04340 Hedgehog signaling pathway - Homo sapiens (human), 12 genes
hsa05230 Central carbon metabolism in cancer - Homo sapiens (human), 12 genes
hsa04922 Glucagon signaling pathway - Homo sapiens (human), 12 genes
hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human), 12 genes
hsa05010 Alzheimer's disease - Homo sapiens (human), 12 genes
hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human), 12 genes
hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human), 12 genes
hsa04920 Adipocytokine signaling pathway - Homo sapiens (human), 12 genes
hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human), 11 genes
hsa05145 Toxoplasmosis - Homo sapiens (human), 11 genes
hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human), 11 genes
hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human), 11 genes
hsa04916 Melanogenesis - Homo sapiens (human), 11 genes
hsa04720 Long-term potentiation - Homo sapiens (human), 10 genes
hsa05133 Pertussis - Homo sapiens (human), 10 genes
hsa04611 Platelet activation - Homo sapiens (human), 10 genes
hsa04270 Vascular smooth muscle contraction - Homo sapiens (human), 10 genes
hsa04020 Calcium signaling pathway - Homo sapiens (human), 10 genes
hsa04912 GnRH signaling pathway - Homo sapiens (human), 9 genes
hsa05231 Choline metabolism in cancer - Homo sapiens (human), 9 genes
hsa05132 Salmonella infection - Homo sapiens (human), 9 genes
hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human), 9 genes
hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human), 9 genes
hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human), 9 genes
hsa05414 Dilated cardiomyopathy - Homo sapiens (human), 9 genes
hsa05321 Inflammatory bowel disease (IBD) - Homo sapiens (human), 8 genes
hsa05031 Amphetamine addiction - Homo sapiens (human), 8 genes
hsa05012 Parkinson's disease - Homo sapiens (human), 8 genes
hsa04915 Estrogen signaling pathway - Homo sapiens (human), 8 genes
hsa05131 Shigellosis - Homo sapiens (human), 8 genes
hsa00270 Cysteine and methionine metabolism - Homo sapiens (human), 8 genes
hsa05034 Alcoholism - Homo sapiens (human), 8 genes
hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human), 8 genes
hsa04640 Hematopoietic cell lineage - Homo sapiens (human), 7 genes
hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human), 7 genes
hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), 7 genes
hsa04512 ECM-receptor interaction - Homo sapiens (human), 7 genes
hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human), 7 genes
hsa04710 Circadian rhythm - Homo sapiens (human), 7 genes
hsa05134 Legionellosis - Homo sapiens (human), 7 genes
hsa03015 mRNA surveillance pathway - Homo sapiens (human), 7 genes
hsa04730 Long-term depression - Homo sapiens (human), 7 genes
hsa04930 Type II diabetes mellitus - Homo sapiens (human), 7 genes
hsa04145 Phagosome - Homo sapiens (human), 7 genes
hsa04724 Glutamatergic synapse - Homo sapiens (human), 7 genes
hsa05146 Amoebiasis - Homo sapiens (human), 7 genes
hsa01230 Biosynthesis of amino acids - Homo sapiens (human), 6 genes
hsa04370 VEGF signaling pathway - Homo sapiens (human), 6 genes
hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human), 6 genes
hsa00330 Arginine and proline metabolism - Homo sapiens (human), 6 genes
hsa04978 Mineral absorption - Homo sapiens (human), 6 genes
hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human), 6 genes
hsa04918 Thyroid hormone synthesis - Homo sapiens (human), 6 genes
hsa04330 Notch signaling pathway - Homo sapiens (human), 6 genes
hsa05216 Thyroid cancer - Homo sapiens (human), 6 genes
hsa04726 Serotonergic synapse - Homo sapiens (human), 6 genes
hsa04725 Cholinergic synapse - Homo sapiens (human), 6 genes
hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human), 6 genes
hsa05140 Leishmaniasis - Homo sapiens (human), 6 genes
hsa01200 Carbon metabolism - Homo sapiens (human), 6 genes
hsa04972 Pancreatic secretion - Homo sapiens (human), 6 genes
hsa04950 Maturity onset diabetes of the young - Homo sapiens (human), 6 genes
hsa03440 Homologous recombination - Homo sapiens (human), 6 genes
hsa04320 Dorso-ventral axis formation - Homo sapiens (human), 6 genes
hsa00590 Arachidonic acid metabolism - Homo sapiens (human), 5 genes
hsa03018 RNA degradation - Homo sapiens (human), 5 genes
hsa00562 Inositol phosphate metabolism - Homo sapiens (human), 5 genes
hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human), 5 genes
hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human), 5 genes
hsa03013 RNA transport - Homo sapiens (human), 5 genes
hsa05323 Rheumatoid arthritis - Homo sapiens (human), 5 genes
hsa03320 PPAR signaling pathway - Homo sapiens (human), 5 genes
hsa00565 Ether lipid metabolism - Homo sapiens (human), 5 genes
hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), 5 genes
hsa04140 Regulation of autophagy - Homo sapiens (human), 4 genes
hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human), 4 genes
hsa04540 Gap junction - Homo sapiens (human), 4 genes
hsa00564 Glycerophospholipid metabolism - Homo sapiens (human), 4 genes
hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human), 4 genes
hsa03430 Mismatch repair - Homo sapiens (human), 4 genes
hsa05340 Primary immunodeficiency - Homo sapiens (human), 4 genes
hsa04970 Salivary secretion - Homo sapiens (human), 4 genes
hsa04911 Insulin secretion - Homo sapiens (human), 4 genes
hsa00480 Glutathione metabolism - Homo sapiens (human), 4 genes
hsa05030 Cocaine addiction - Homo sapiens (human), 4 genes
hsa04713 Circadian entrainment - Homo sapiens (human), 4 genes
hsa05110 Vibrio cholerae infection - Homo sapiens (human), 3 genes
hsa04976 Bile secretion - Homo sapiens (human), 3 genes
hsa03010 Ribosome - Homo sapiens (human), 3 genes
hsa00230 Purine metabolism - Homo sapiens (human), 3 genes
hsa05143 African trypanosomiasis - Homo sapiens (human), 3 genes
hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human), 3 genes
hsa04727 GABAergic synapse - Homo sapiens (human), 3 genes
hsa03420 Nucleotide excision repair - Homo sapiens (human), 3 genes
hsa00591 Linoleic acid metabolism - Homo sapiens (human), 3 genes
hsa04146 Peroxisome - Homo sapiens (human), 3 genes
hsa05020 Prion diseases - Homo sapiens (human), 3 genes
hsa00310 Lysine degradation - Homo sapiens (human), 3 genes
hsa05416 Viral myocarditis - Homo sapiens (human), 3 genes
hsa04971 Gastric acid secretion - Homo sapiens (human), 3 genes
hsa00190 Oxidative phosphorylation - Homo sapiens (human), 3 genes
hsa04614 Renin-angiotensin system - Homo sapiens (human), 2 genes
hsa00592 alpha-Linolenic acid metabolism - Homo sapiens (human), 2 genes
hsa05144 Malaria - Homo sapiens (human), 2 genes
hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human), 2 genes
hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human), 2 genes
hsa04974 Protein digestion and absorption - Homo sapiens (human), 2 genes
hsa00040 Pentose and glucuronate interconversions - Homo sapiens (human), 2 genes
hsa04672 Intestinal immune network for IgA production - Homo sapiens (human), 2 genes
hsa04940 Type I diabetes mellitus - Homo sapiens (human), 2 genes
hsa05322 Systemic lupus erythematosus - Homo sapiens (human), 2 genes
hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human), 2 genes
hsa00051 Fructose and mannose metabolism - Homo sapiens (human), 2 genes
hsa03410 Base excision repair - Homo sapiens (human), 2 genes
hsa05204 Chemical carcinogenesis - Homo sapiens (human), 2 genes
hsa02010 ABC transporters - Homo sapiens (human), 2 genes
hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human), 2 genes
hsa00052 Galactose metabolism - Homo sapiens (human), 1 gene
hsa00240 Pyrimidine metabolism - Homo sapiens (human), 1 gene
hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human), 1 gene
hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human), 1 gene
hsa05330 Allograft rejection - Homo sapiens (human), 1 gene
hsa01212 Fatty acid metabolism - Homo sapiens (human), 1 gene
hsa00340 Histidine metabolism - Homo sapiens (human), 1 gene
hsa00360 Phenylalanine metabolism - Homo sapiens (human), 1 gene
hsa04913 Ovarian steroidogenesis - Homo sapiens (human), 1 gene
hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human), 1 gene
hsa03030 DNA replication - Homo sapiens (human), 1 gene
hsa00900 Terpenoid backbone biosynthesis - Homo sapiens (human), 1 gene
hsa00430 Taurine and hypotaurine metabolism - Homo sapiens (human), 1 gene
hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human), 1 gene
hsa00620 Pyruvate metabolism - Homo sapiens (human), 1 gene
hsa04610 Complement and coagulation cascades - Homo sapiens (human), 1 gene
hsa04744 Phototransduction - Homo sapiens (human), 1 gene
hsa04142 Lysosome - Homo sapiens (human), 1 gene
hsa00520 Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), 1 gene
hsa05033 Nicotine addiction - Homo sapiens (human), 1 gene
hsa00030 Pentose phosphate pathway - Homo sapiens (human), 1 gene
hsa05320 Autoimmune thyroid disease - Homo sapiens (human), 1 gene
hsa00600 Sphingolipid metabolism - Homo sapiens (human), 1 gene
hsa00510 N-Glycan biosynthesis - Homo sapiens (human), 1 gene
hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human), 1 gene
hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human), 1 gene
hsa01040 Biosynthesis of unsaturated fatty acids - Homo sapiens (human), 1 gene
hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human), 1 gene
hsa04612 Antigen processing and presentation - Homo sapiens (human), 1 gene
hsa00380 Tryptophan metabolism - Homo sapiens (human), 1 gene
hsa00830 Retinol metabolism - Homo sapiens (human), 1 gene
hsa00790 Folate biosynthesis - Homo sapiens (human), 1 gene
hsa03450 Non-homologous end-joining - Homo sapiens (human), 1 gene
hsa00514 Other types of O-glycan biosynthesis - Homo sapiens (human), 1 gene
hsa00062 Fatty acid elongation - Homo sapiens (human), 1 gene
hsa05032 Morphine addiction - Homo sapiens (human), 1 gene
hsa00500 Starch and sucrose metabolism - Homo sapiens (human), 1 gene
hsa04975 Fat digestion and absorption - Homo sapiens (human), 1 gene
hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human), 1 gene
hsa03040 Spliceosome - Homo sapiens (human), 1 gene
hsa05332 Graft-versus-host disease - Homo sapiens (human), 1 gene
hsa00350 Tyrosine metabolism - Homo sapiens (human), 1 gene
hsa04260 Cardiac muscle contraction - Homo sapiens (human), 1 gene
hsa00410 beta-Alanine metabolism - Homo sapiens (human), 1 gene
hsa00471 D-Glutamine and D-glutamate metabolism - Homo sapiens (human), 1 gene
hsa00860 Porphyrin and chlorophyll metabolism - Homo sapiens (human), 1 gene
hsa00561 Glycerolipid metabolism - Homo sapiens (human), 1 gene