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General annoucement
All the data is free to download and use for academic purpose. For commercial purpose, please contact us via email. All the downloadable files are tab-seperated text files. The headline of each file provides the information for each column.
All the 1217 human tumor suppressor genes with basic annotations
The flat file is here.
All the precomputed P-values for gene expression difference between tumor and normal samples for all human tumor suppressor genes in pan-cancer
The flat file is here.
Download the down-regulated tumor suppressor genes in tumor samples versus normal tissue
All the down regulated 983 human TSGs are lower expressed in cancer samples of TCGA comparing to the TCGA normal tissue samples.
BLCA : 493 human TSGs that are down-regulated in bladder urothelial carcinoma samples compared to normal tissue samples in TCGA.
BRCA : 589 human TSGs that are down-regulated in breast invasive carcinoma samples compared to normal tissue samples in TCGA.
COAD : 535 human TSGs that are down-regulated in colon adenocarcinoma samples compared to normal tissue samples in TCGA.
HNSC : 445 human TSGs that are down-regulated in head and neck squamous cell carcinoma samples compared to normal tissue samples in TCGA.
KICH : 568 human TSGs that are down-regulated in kidney chromophobe samples compared to normal tissue samples in TCGA.
KIRC : 491 human TSGs that are down-regulated in kidney renal clear cell carcinoma samples compared to normal tissue samples in TCGA.
LUAD : 525 human TSGs that are down-regulated in lung adenocarcinoma samples compared to normal tissue samples in TCGA.
LUSC : 534 human TSGs that are down-regulated in lung squamous cell carcinoma samples compared to normal tissue samples in TCGA.
PRAD : 564 human TSGs that are down-regulated in prostate adenocarcinoma samples compared to normal tissue samples in TCGA.
THCA : 486 human TSGs that are down-regulated in thyroid carcinoma samples compared to normal tissue samples in TCGA.
UCEC : 526 human TSGs that are down-regulated in uterine corpus endometrial carcinoma samples compared to normal tissue samples in TCGA.
When using this resource, please cite:
Min Zhao, Jingchun Sun, Zhongming Zhao. TSGene: a web resource for tumor suppressor genes.Nucleic Acids Research, 2013 Jan;41(Database issue):D970-6. Min Zhao, Pora Kim, Ramkrishna Mitra, Junfei Zhao, Zhongming Zhao. TSGene 2.0: a literature-based database of tumor suppressor genes for pan-cancer analysis.