About TissGDB

TissGDB is the tissue-specific gene annotation database in cancer, aiming to provide a resource or reference for cancer and the related disease studies in the context of tissue specificity. We first collected 8,172 TissGenes across 22 tissue types, which are matched with the 28 cancer types of The Cancer Genome Atlas (TCGA) project, from three representative tissue-specific gene expression resources: The Human Protein Atlas (HPA), tissue-specific gene expression and regulation (TiGER), and Genotype-Tissue Expression (GTEx). Finally, we selected 2,461 TissGenes retrieved from at least two tissue-specific gene expression resources to ensure tissue specificity of the genes. For these 2,461 TissGenes, we performed gene expression, somatic mutation, and prognostic-based analyses across 28 cancer types using TCGA data through seven categories of annotations: TissGeneSummary, TissGeneExp, TissGene-miRNA, TissGeneMut, TissGeneNet, TissGeneProg, and TissGeneClin.