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| TissGeneSummary for CDH6 |
 Gene summary |
| Basic gene information | Gene symbol | CDH6 |
| Gene name | cadherin 6, type 2, K-cadherin (fetal kidney) | |
| Synonyms | CAD6|KCAD | |
| Cytomap | UCSC genome browser: 5p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004932.3, | |
| Description | cadherin-6 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603007 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000113361 | ||
| HPRD : 04305 | ||
| Vega : OTTHUMG00000090673 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CDH6 | |
| BioGPS: 1004 | ||
| Pathway | NCI Pathway Interaction Database: CDH6 | |
| KEGG: CDH6 | ||
| REACTOME: CDH6 | ||
| Pathway Commons: CDH6 | ||
| Context | iHOP: CDH6 | |
| ligand binding site mutation search in PubMed: CDH6 | ||
| UCL Cancer Institute: CDH6 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHOV | |
| Reference showing the relevant tissue of CDH6 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CDH6 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 4.74521445 | 2.274922784 | 2.470291667 | 8.38E-21 | 7.09E-20 |
| LUSC | -1.122450664 | 0.26475914 | -1.387209804 | 2.61E-05 | 5.73E-05 |
| THCA | 1.052331988 | -1.354591741 | 2.406923729 | 1.30E-16 | 2.25E-15 |
| KICH | -1.359439605 | 1.027808395 | -2.387248 | 2.57E-07 | 1.08E-06 |
| KIRP | 3.586615145 | 1.98936827 | 1.597246875 | 0.0011 | 0.003007561 |
| COAD | -1.404938221 | -2.502865144 | 1.097926923 | 0.000151 | 0.000525144 |
| HNSC | -1.742054768 | -2.801171047 | 1.059116279 | 2.31E-05 | 0.000120592 |
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| TissGene-miRNA for CDH6 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CDH6 |
| TissGeneSNV for CDH6 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S524L | SKCM | 8 |
| p.E722K | SKCM | 6 |
| p.G247E | SKCM | 3 |
| p.P704S | SKCM | 2 |
| p.D726N | SKCM | 2 |
| p.E302K | SKCM | 2 |
| p.R689Q | SKCM | 2 |
| p.F60L | COAD | 2 |
| p.D188N | SKCM | 2 |
| p.D691N | SKCM | 2 |
| p.E662K | SKCM | 2 |
| p.K34N | SKCM | 1 |
| p.D779V | SKCM | 1 |
| p.R773Q | SKCM | 1 |
| p.R226* | PCPG | 1 |
| p.Q540H | HNSC | 1 |
| p.L688V | UCEC | 1 |
| p.D733N | STAD | 1 |
| p.E230K | BLCA | 1 |
| p.D759Y | LUAD | 1 |
| p.L582P | STAD | 1 |
| p.N545Y | SKCM | 1 |
| p.S524L | UVM | 1 |
| p.K467E | UCEC | 1 |
| p.R448Q | SKCM | 1 |
| p.T609M | BRCA | 1 |
| p.V354G | ESCA | 1 |
| p.D309Y | BLCA | 1 |
| p.R115K | LIHC | 1 |
| p.R653* | LUAD | 1 |
| p.R429I | LUAD | 1 |
| p.G310C | LUAD | 1 |
| p.P356L | SKCM | 1 |
| p.F208L | COAD | 1 |
| p.E156* | LUAD | 1 |
| p.S600T | LUAD | 1 |
| p.K161E | LUAD | 1 |
| p.V370A | SKCM | 1 |
| p.P731S | HNSC | 1 |
| p.P583L | SKCM | 1 |
| p.T613M | PRAD | 1 |
| p.T344A | COAD | 1 |
| p.P772R | SKCM | 1 |
| p.R229K | LUAD | 1 |
| p.E326* | LUAD | 1 |
| p.K339R | SKCM | 1 |
| p.E375K | BLCA | 1 |
| p.Y191F | LGG | 1 |
| p.W770C | LUAD | 1 |
| p.S443L | SKCM | 1 |
| p.P704T | LUAD | 1 |
| p.R137I | LUAD | 1 |
| p.Y343F | STAD | 1 |
| p.E105* | LUAD | 1 |
| p.D434N | STAD | 1 |
| p.S580T | LUAD | 1 |
| p.R133K | SKCM | 1 |
| p.L92F | SKCM | 1 |
| p.D515N | SKCM | 1 |
| p.S600Y | ACC | 1 |
| p.T725K | HNSC | 1 |
| p.R640Q | SKCM | 1 |
| p.S44R | LUAD | 1 |
| p.K341I | SKCM | 1 |
| p.E119K | SKCM | 1 |
| p.D409Y | LUAD | 1 |
| p.S749F | SKCM | 1 |
| p.E144K | SKCM | 1 |
| p.F7C | BRCA | 1 |
| p.D173N | HNSC | 1 |
| p.R50C | STAD | 1 |
| p.N351S | BRCA | 1 |
| p.P583H | HNSC | 1 |
| p.G243R | LUAD | 1 |
| p.N351H | STAD | 1 |
| p.D480Y | THYM | 1 |
| p.V756L | HNSC | 1 |
| p.L334F | SKCM | 1 |
| p.G438D | SKCM | 1 |
| p.R587Q | SKCM | 1 |
| p.L697I | HNSC | 1 |
| p.D70N | STAD | 1 |
| p.P416S | SKCM | 1 |
| p.K45T | ESCA | 1 |
| p.D483N | SKCM | 1 |
| p.A500T | SKCM | 1 |
| p.R773* | HNSC | 1 |
| p.Y353* | STAD | 1 |
| p.P380A | LUAD | 1 |
| p.R53K | SKCM | 1 |
| p.Q507E | LUAD | 1 |
| p.D314N | SKCM | 1 |
| p.Q205E | LUAD | 1 |
| p.Q322H | LUAD | 1 |
| p.Y353X | STAD | 1 |
| p.Y164* | BRCA | 1 |
| p.T176A | SKCM | 1 |
| p.A528T | PRAD | 1 |
| p.L92I | UCEC | 1 |
| p.S579C | LUSC | 1 |
| p.R640Q | READ | 1 |
| p.Y591C | CESC | 1 |
| p.A500S | LUAD | 1 |
| p.G582E | SKCM | 1 |
| p.A349D | THCA | 1 |
| p.R127* | SKCM | 1 |
| p.P266S | SKCM | 1 |
| p.D376Y | LUSC | 1 |
| p.D515H | BLCA | 1 |
| p.Q468R | LUAD | 1 |
| p.T113P | KIRP | 1 |
| p.L345F | SKCM | 1 |
| p.R701Q | UCEC | 1 |
| p.L636Q | LUAD | 1 |
| p.S535* | BLCA | 1 |
| p.V481I | LUAD | 1 |
| p.E213K | HNSC | 1 |
| p.T184M | PAAD | 1 |
| p.V354G | STAD | 1 |
| p.S526F | SKCM | 1 |
| p.R689* | LGG | 1 |
| p.E662G | OV | 1 |
| p.E304Q | HNSC | 1 |
| p.L527F | BLCA | 1 |
| p.S439L | READ | 1 |
| p.V139L | LUSC | 1 |
| p.Y199X | STAD | 1 |
| p.R423Q | STAD | 1 |
| p.E741K | OV | 1 |
| p.L258M | LUAD | 1 |
| p.R773Q | LUAD | 1 |
| p.R587W | BLCA | 1 |
| p.R118K | SKCM | 1 |
| p.D761Y | ESCA | 1 |
| p.K52Q | SKCM | 1 |
| p.Q81H | STAD | 1 |
| p.K121E | LUAD | 1 |
| p.G243S | OV | 1 |
| p.R587Q | STAD | 1 |
| p.V746M | BLCA | 1 |
| p.G327E | SKCM | 1 |
| p.D263N | SKCM | 1 |
| p.D294N | BLCA | 1 |
| p.Q391K | LUAD | 1 |
| p.R638W | LIHC | 1 |
| p.E490K | BLCA | 1 |
| p.S439L | SKCM | 1 |
| p.E741K | ESCA | 1 |
| p.R689X | LGG | 1 |
| p.V163D | SKCM | 1 |
| p.T184M | COAD | 1 |
| p.R707C | STAD | 1 |
| p.D661N | SKCM | 1 |
| p.A760E | LUAD | 1 |
| p.T609M | CHOL | 1 |
| p.G310S | COAD | 1 |
| p.D263V | KIRC | 1 |
| p.D574N | SKCM | 1 |
| p.Q270K | LUAD | 1 |
| p.A602T | COAD | 1 |
| p.L445R | STAD | 1 |
| p.G98E | SKCM | 1 |
| p.Y199* | STAD | 1 |
| p.H78R | MESO | 1 |
| p.P283S | SKCM | 1 |
| p.G42A | OV | 1 |
| p.A602T | CESC | 1 |
| p.M171I | LUAD | 1 |
| p.A130D | KIRP | 1 |
| p.R640Q | COAD | 1 |
| p.P680S | SKCM | 1 |
| p.A183V | THYM | 1 |
| p.Q639K | LUAD | 1 |
| p.D366N | SKCM | 1 |
| p.P189S | SKCM | 1 |
| p.S21L | SKCM | 1 |
| p.R229S | ESCA | 1 |
| p.P730S | SKCM | 1 |
| p.P466S | PAAD | 1 |
| p.R552P | SARC | 1 |
| p.P265L | SKCM | 1 |
| p.E603K | SKCM | 1 |
| p.D661H | BLCA | 1 |
| p.D661N | LUSC | 1 |
| p.L359V | ESCA | 1 |
| p.D691G | BLCA | 1 |
| p.R357L | HNSC | 1 |
| p.M427T | LIHC | 1 |
| p.T546M | COAD | 1 |
| p.Q129* | SKCM | 1 |
| p.G548E | SKCM | 1 |
| p.R701Q | BLCA | 1 |
| p.S143F | SKCM | 1 |
| p.G310D | SKCM | 1 |
| p.S443L | COAD | 1 |
| p.R689X | COAD | 1 |
| p.P269S | SKCM | 1 |
| p.P517A | BLCA | 1 |
| p.V254A | STAD | 1 |
| p.Q237K | LUAD | 1 |
| p.S41C | PRAD | 1 |
| p.R707C | SKCM | 1 |
| p.S790C | LUAD | 1 |
| p.D70Y | LUAD | 1 |
| p.A547V | PRAD | 1 |
| p.S526Y | READ | 1 |
| p.D711N | LUAD | 1 |
| p.R678G | LUAD | 1 |
| p.L359F | SKCM | 1 |
| p.K341T | PRAD | 1 |
| p.R267Q | SKCM | 1 |
| p.R448* | SKCM | 1 |
| p.N155D | COAD | 1 |
| p.I652S | UCEC | 1 |
| p.P32Q | SKCM | 1 |
| p.G94V | LUAD | 1 |
| p.T190A | HNSC | 1 |
| p.D154N | SKCM | 1 |
| p.G86R | SKCM | 1 |
| p.A128S | HNSC | 1 |
| Top |
| TissGeneCNV for CDH6 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CDH6 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BLCA | TCGA-G2-A3VY-01A | NUP133-CDH6 | Out-of-frame | Chr1:229625702 | Chr5:31299571 |
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| TissGeneNet for CDH6 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| COAD (tumor) | COAD (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| KICH (tumor) | KICH (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| STAD (tumor) | STAD (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| THCA (tumor) | THCA (normal) |
| CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (tumor) | CDH6, CTNNB1, CDH9, CDH18, CDH10, CDH7, CDH19 (normal) |
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| Top |
| TissGeneProg for CDH6 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for CDH6 |
| TissGeneDrug for CDH6 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CDH6 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007134 | Renal Cell Carcinoma | 5 | BeFree |
| umls:C1378703 | Renal carcinoma | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0006625 | Cachexia | 1 | CTD_human |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree,GAD |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0040136 | Thyroid Neoplasm | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1334603 | Malignant Mixed Mesodermal (Mullerian) Tumor | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
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