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| TissGeneSummary for SOHLH2 |
 Gene summary |
| Basic gene information | Gene symbol | SOHLH2 |
| Gene name | ||
| Synonyms | ||
| Cytomap | UCSC genome browser: | |
| Type of gene | ||
| RefGenes | ||
| Description | ||
| Modification date | ||
| dbXrefs | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SOHLH2 | |
| BioGPS: 100526761 | ||
| Pathway | NCI Pathway Interaction Database: SOHLH2 | |
| KEGG: SOHLH2 | ||
| REACTOME: SOHLH2 | ||
| Pathway Commons: SOHLH2 | ||
| Context | iHOP: SOHLH2 | |
| ligand binding site mutation search in PubMed: SOHLH2 | ||
| UCL Cancer Institute: SOHLH2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SOHLH2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SOHLH2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -1.085990451 | -2.767164961 | 1.68117451 | 1.17E-07 | 3.26E-07 |
| LUAD | -0.653654853 | -2.772401404 | 2.118746552 | 4.16E-09 | 1.97E-08 |
| LIHC | -2.466954922 | -3.620040922 | 1.153086 | 0.00134 | 0.003590036 |
| STAD | -2.735541922 | -0.972876297 | -1.762665625 | 0.000382 | 0.002461656 |
| COAD | -3.259132306 | -0.966043845 | -2.293088462 | 2.59E-05 | 0.000107475 |
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| TissGene-miRNA for SOHLH2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SOHLH2 |
| TissGeneSNV for SOHLH2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.K85R | STAD | 3 |
| p.K250N | UCEC | 2 |
| p.A2S | UCEC | 1 |
| p.C63R | LIHC | 1 |
| p.C139F | STAD | 1 |
| p.E266K | UCEC | 1 |
| p.R88K | STAD | 1 |
| p.T53M | COAD | 1 |
| p.S358P | UCEC | 1 |
| p.S4L | SKCM | 1 |
| p.A259V | SKCM | 1 |
| p.M129I | SKCM | 1 |
| p.E341D | UCEC | 1 |
| p.G318V | LIHC | 1 |
| p.G15S | LUAD | 1 |
| p.P229T | COAD | 1 |
| p.Q68K | TGCT | 1 |
| p.Q278L | ESCA | 1 |
| p.N417K | LUAD | 1 |
| p.E127K | COAD | 1 |
| p.G184C | BLCA | 1 |
| p.S14L | SKCM | 1 |
| p.K85T | STAD | 1 |
| p.P390L | BLCA | 1 |
| p.Q223K | STAD | 1 |
| p.V371G | UCEC | 1 |
| p.C275S | LGG | 1 |
| p.G233E | SKCM | 1 |
| p.S14L | COAD | 1 |
| p.L311M | LUAD | 1 |
| p.S340* | BLCA | 1 |
| p.T364I | HNSC | 1 |
| p.R225P | LUAD | 1 |
| p.S130N | STAD | 1 |
| p.P394S | READ | 1 |
| p.N296S | LUAD | 1 |
| p.T28N | KIRC | 1 |
| p.D406N | CESC | 1 |
| p.A356T | COAD | 1 |
| p.E254* | LUAD | 1 |
| p.P229L | COAD | 1 |
| p.L286F | SKCM | 1 |
| p.G168E | UCEC | 1 |
| p.A239V | ACC | 1 |
| p.S257F | SKCM | 1 |
| p.C177R | STAD | 1 |
| p.P229L | STAD | 1 |
| p.M67T | LUAD | 1 |
| p.T146I | LUAD | 1 |
| p.A331T | COAD | 1 |
| p.A238V | STAD | 1 |
| p.H166Y | SKCM | 1 |
| p.D237E | STAD | 1 |
| p.P347S | SKCM | 1 |
| p.A83T | BLCA | 1 |
| p.S178C | STAD | 1 |
| p.W423* | UCEC | 1 |
| p.E154* | UCEC | 1 |
| p.Q223K | LUAD | 1 |
| p.H388Y | SKCM | 1 |
| p.G233R | STAD | 1 |
| p.L39Q | BLCA | 1 |
| p.P258A | HNSC | 1 |
| p.N199T | ESCA | 1 |
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| TissGeneCNV for SOHLH2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SOHLH2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BQ432991 | PPP6R1-SOHLH2 | chr19:55742831 | chr13:36742353 |
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| TissGeneNet for SOHLH2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| COAD (tumor) | COAD (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| KICH (tumor) | KICH (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| STAD (tumor) | STAD (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| THCA (tumor) | THCA (normal) |
| SOHLH2, TCEB3B (tumor) | SOHLH2, TCEB3B (normal) |
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| TissGeneProg for SOHLH2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SOHLH2 |
| TissGeneDrug for SOHLH2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SOHLH2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004509 | Azoospermia | 1 | BeFree |
| umls:C0004997 | Benign Ovarian Neoplasm | 1 | BeFree |
| umls:C0025322 | Premature Menopause | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0085215 | Ovarian Failure, Premature | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0747102 | Ovarian failure | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
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