TissGeneSummary for CHEK1 |
Gene summary |
Basic gene information | Gene symbol | CHEK1 |
Gene name | checkpoint kinase 1 | |
Synonyms | CHK1 | |
Cytomap | UCSC genome browser: 11q24.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001114121.2, NM_001114122.2,NM_001244846.1,NM_001274.5,NR_045204.1, NR_045205.1, | |
Description | CHK1 checkpoint homologCheckpoint, S. pombe, homolog of, 1Chk1-Scell cycle checkpoint kinasecheckpoint kinase-1serine/threonine-protein kinase Chk1 | |
Modification date | 20141222 | |
dbXrefs | MIM : 603078 | |
HGNC : HGNC | ||
Ensembl : ENSG00000149554 | ||
HPRD : 04356 | ||
Vega : OTTHUMG00000165853 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CHEK1 | |
BioGPS: 1111 | ||
Pathway | NCI Pathway Interaction Database: CHEK1 | |
KEGG: CHEK1 | ||
REACTOME: CHEK1 | ||
Pathway Commons: CHEK1 | ||
Context | iHOP: CHEK1 | |
ligand binding site mutation search in PubMed: CHEK1 | ||
UCL Cancer Institute: CHEK1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
Reference showing the relevant tissue of CHEK1 | ||
Description by TissGene annotations | Cancer gene TissgsLTS Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0000077 | DNA damage checkpoint | 16963448 | GO:0006975 | DNA damage induced protein phosphorylation | 16963448 | GO:0010569 | regulation of double-strand break repair via homologous recombination | 15665856 | GO:0018107 | peptidyl-threonine phosphorylation | 15665856 | GO:0045839 | negative regulation of mitosis | 15311285 | GO:0046602 | regulation of mitotic centrosome separation | 15311285 | GO:0000077 | DNA damage checkpoint | 16963448 | GO:0006975 | DNA damage induced protein phosphorylation | 16963448 | GO:0010569 | regulation of double-strand break repair via homologous recombination | 15665856 | GO:0018107 | peptidyl-threonine phosphorylation | 15665856 | GO:0045839 | negative regulation of mitosis | 15311285 | GO:0046602 | regulation of mitotic centrosome separation | 15311285 |
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TissGeneExp for CHEK1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -1.512060393 | -2.759754393 | 1.247694 | 5.89E-12 | 9.99E-11 |
BRCA | -0.67300106 | -1.843313341 | 1.170312281 | 7.36E-23 | 6.43E-22 |
LUAD | -0.693196462 | -2.703889566 | 2.010693103 | 2.88E-20 | 6.15E-19 |
LUSC | 0.287294038 | -2.631405962 | 2.9187 | 1.06E-37 | 3.98E-35 |
COAD | 0.39359253 | -0.726834393 | 1.120426923 | 4.99E-15 | 3.04E-13 |
STAD | -0.124321893 | -1.350906268 | 1.226584375 | 1.52E-11 | 2.63E-09 |
BLCA | 0.02090508 | -1.747668604 | 1.768573684 | 2.45E-07 | 1.09E-05 |
HNSC | 0.019955142 | -1.153935556 | 1.173890698 | 3.48E-12 | 1.06E-10 |
ESCA | -0.186202575 | -2.157593484 | 1.971390909 | 5.66E-06 | 0.000899131 |
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TissGene-miRNA for CHEK1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CHEK1 |
TissGeneSNV for CHEK1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D130Y | LUSC | 1 |
p.K337X | LIHC | 1 |
p.R419S | LUSC | 1 |
p.R442W | STAD | 1 |
p.G324C | LUAD | 1 |
p.E223A | COAD | 1 |
p.K166N | UCEC | 1 |
p.M1T | LUSC | 1 |
p.E32D | KIRP | 1 |
p.X477C | PRAD | 1 |
p.R160L | ESCA | 1 |
p.R160H | UCEC | 1 |
p.D235N | UCEC | 1 |
p.T279I | LIHC | 1 |
p.K232N | GBM | 1 |
p.G289* | LUSC | 1 |
p.F93V | STAD | 1 |
p.E309K | BLCA | 1 |
p.R29G | LGG | 1 |
p.I58V | LGG | 1 |
p.S284L | STAD | 1 |
p.R379* | HNSC | 1 |
p.K337* | LIHC | 1 |
p.R160C | LGG | 1 |
p.R160C | SKCM | 1 |
p.D235Y | LUSC | 1 |
p.G72V | THYM | 1 |
p.V46A | LUAD | 1 |
p.V312M | THCA | 1 |
p.R109* | LUAD | 1 |
p.G446D | LUAD | 1 |
p.H122Y | LUAD | 1 |
p.G324C | SARC | 1 |
p.Q295E | BLCA | 1 |
p.S296F | SKCM | 1 |
p.D336N | STAD | 1 |
p.L136F | CESC | 1 |
p.R322H | COAD | 1 |
p.R156W | READ | 1 |
p.V119F | ESCA | 1 |
p.R322H | LIHC | 1 |
p.R379Q | STAD | 1 |
p.M167L | GBM | 1 |
p.R141S | LUAD | 1 |
p.R160H | GBM | 1 |
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TissGeneCNV for CHEK1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CHEK1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CB142976 | CHEK1-DCAF8 | chr11:125499303 | chr1:160248873 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OW-01A | CTNNB1-CHEK1 | 5'UTR-5'UTR | chr3:41241161 | chr11:125496643 |
TCGAfusionPortal | PRADA | BRCA | TCGA-OL-A66P-01A | TMEM135-CHEK1 | CDS-3UTR | Chr11:86802437 | Chr11:125545823 |
TCGAfusionPortal | PRADA | OV | TCGA-09-1665-01B | CHEK1-EXOC6 | Out-of-frame | Chr11:125505428 | Chr10:94757231 |
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TissGeneNet for CHEK1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CHEK1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CHEK1 |
TissGeneDrug for CHEK1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CHEK1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 28 | BeFree,GAD |
umls:C0678222 | Breast Carcinoma | 23 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 13 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 11 | BeFree |
umls:C0015625 | Fanconi Anemia | 9 | BeFree,LHGDN |
umls:C0004135 | Ataxia Telangiectasia | 8 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 8 | BeFree |
umls:C0023418 | leukemia | 7 | BeFree |
umls:C0025202 | melanoma | 7 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 7 | BeFree,GAD |
umls:C0346647 | Malignant neoplasm of pancreas | 7 | BeFree |
umls:C1527249 | Colorectal Cancer | 7 | BeFree,GAD |
umls:C2239176 | Liver carcinoma | 7 | BeFree,LHGDN |
umls:C0009402 | Colorectal Carcinoma | 6 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 6 | BeFree |
umls:C0596263 | Carcinogenesis | 6 | BeFree |
umls:C0302592 | Cervix carcinoma | 5 | BeFree |
umls:C0684249 | Carcinoma of lung | 5 | BeFree |
umls:C3469521 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 5 | BeFree |
umls:C3539878 | Triple Negative Breast Neoplasms | 5 | BeFree |
umls:C0007102 | Malignant tumor of colon | 4 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 4 | BeFree |
umls:C0017638 | Glioma | 4 | BeFree,GAD |
umls:C0699790 | Colon Carcinoma | 4 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 3 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 3 | BeFree |
umls:C0024299 | Lymphoma | 3 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 3 | BeFree |
umls:C0280100 | Solid tumour | 3 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C1458155 | Mammary Neoplasms | 3 | BeFree,CTD_human |
umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree,GAD |
umls:C0012860 | DNA Damage | 2 | GAD |
umls:C0026764 | Multiple Myeloma | 2 | BeFree |
umls:C0027819 | Neuroblastoma | 2 | BeFree |
umls:C0029463 | Osteosarcoma | 2 | BeFree,LHGDN |
umls:C0035335 | Retinoblastoma | 2 | BeFree |
umls:C0085390 | Li-Fraumeni Syndrome | 2 | BeFree |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0346153 | Breast Cancer, Familial | 2 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 2 | BeFree,GAD |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C0700095 | Central neuroblastoma | 2 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0001486 | Adenovirus Infections | 1 | BeFree |
umls:C0002871 | Anemia | 1 | BeFree |
umls:C0002894 | Refractory anaemia with excess blasts | 1 | BeFree |
umls:C0004134 | Ataxia | 1 | BeFree |
umls:C0006118 | Brain Neoplasms | 1 | GAD |
umls:C0006840 | Candidiasis | 1 | BeFree |
umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
umls:C0009207 | Cockayne Syndrome | 1 | BeFree |
umls:C0009375 | Colonic Neoplasms | 1 | GAD,LHGDN |
umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0024301 | Lymphoma, Follicular | 1 | BeFree |
umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | LHGDN |
umls:C0025007 | Measles | 1 | BeFree |
umls:C0025286 | Meningioma | 1 | GAD |
umls:C0025958 | Microcephaly | 1 | BeFree,LHGDN |
umls:C0027019 | Myelomonocytic leukemia | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0027859 | Acoustic Neuroma | 1 | GAD |
umls:C0030297 | Pancreatic Neoplasm | 1 | GAD |
umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
umls:C0032578 | Polyploidy | 1 | CTD_human |
umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
umls:C0032927 | Precancerous Conditions | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
umls:C0043346 | Xeroderma Pigmentosum | 1 | BeFree |
umls:C0085669 | Acute leukemia | 1 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
umls:C0153252 | Systemic candidiasis | 1 | BeFree |
umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
umls:C0238033 | Carcinoma of Male Breast | 1 | BeFree |
umls:C0242787 | Malignant neoplasm of male breast | 1 | BeFree |
umls:C0265202 | Seckel syndrome | 1 | BeFree |
umls:C0333516 | Tumor necrosis | 1 | BeFree |
umls:C0334108 | Multiple polyps | 1 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C0887833 | Carcinoma, Pancreatic Ductal | 1 | GAD |
umls:C0920269 | Microsatellite Instability | 1 | GAD |
umls:C1096616 | Contralateral breast cancer | 1 | BeFree |
umls:C1512981 | Mammary Tumorigenesis | 1 | BeFree |
umls:C1559154 | Rash and Dermatitis Adverse Event Associated with Chemoradiation | 1 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
umls:C1955934 | Trichothiodystrophy Syndromes | 1 | BeFree |
umls:C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | BeFree |
umls:C3711387 | Autosomal Recessive Primary Microcephaly | 1 | BeFree |