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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CISH
check button Gene summary
Basic gene informationGene symbolCISH
Gene namecytokine inducible SH2-containing protein
SynonymsBACTS2|CIS|CIS-1|G18|SOCS
CytomapUCSC genome browser: 3p21.3
Type of geneprotein-coding
RefGenesNM_013324.5,
NM_145071.2,
Descriptioncytokine-inducible SH2-containing proteincytokine-inducible inhibitor of signaling type 1Bsuppressor of cytokine signaling
Modification date20141207
dbXrefs MIM : 602441
HGNC : HGNC
Ensembl : ENSG00000114737
HPRD : 03897
Vega : OTTHUMG00000156853
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CISH
BioGPS: 1154
PathwayNCI Pathway Interaction Database: CISH
KEGG: CISH
REACTOME: CISH
Pathway Commons: CISH
ContextiHOP: CISH
ligand binding site mutation search in PubMed: CISH
UCL Cancer Institute: CISH
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Bone marrowOvaryThyroid gland
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LAMLOVTHCA
Reference showing the relevant tissue of CISH
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for CISH

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LIHC1.0816339012.194265901-1.1126321.40E-067.30E-06
LUSC-0.1928789621.720738685-1.9136176478.41E-241.58E-22


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TissGene-miRNA for CISH

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CISH
TissGeneSNV for CISH

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P197SLIHC1
p.H128YHNSC1
p.S239RSARC1
p.A191VSTAD1
p.Q178HLIHC1
p.S146FBLCA1
p.S163FBLCA1
p.S190NSTAD1
p.R238CLGG1
p.D152YLUAD1
p.P53LSKCM1
p.A208VSTAD1
p.F91LUCEC1
p.P27LSKCM1
p.K205ELIHC1
p.E65DKIRP1
p.S235NCOAD1
p.R263CCOAD1
p.S173NSTAD1
p.S103FSKCM1
p.V247ISARC1
p.H111YHNSC1
p.R156GPAAD1
p.R139GPAAD1
p.A253VSTAD1
p.L94IDLBC1
p.R164KSKCM1


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TissGeneCNV for CISH

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CISH

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABE074580CISH-CISHchr3:50644814chr3:50644869
Chimerdb3.0ChiTaRsNAAW438759AMMECR1-CISHchrX:109437660chr3:50645044


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TissGeneNet for CISH

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CISH, CUL5, CUL2, ERBB2, PRKCA, STAT5B, SMAD2, TCEB1, CSF2RB, IL3RA, EGFR, GNB2L1, HSPA6, DYNLL1, PRKCB, PRLR, BCL2L11, PRKCQ, GHR, KIT, ETV5 (tumor)CISH, CUL2, ERBB2, PRKCA, STAT5B, SMAD2, CCNE1, NFKBIA, TCEB1, IL3RA, CSF3R, EGFR, TCEB2, GNB2L1, STAT5A, PRLR, PRKCQ, GHR, EPOR, KIT, ETV5 (normal)
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COAD (tumor)COAD (normal)
CISH, CUL5, CUL2, ERBB2, PRKCA, VHL, STAT3, STAT5B, SMAD2, CCNE1, TCEB1, CSF2RB, IL2RB, GNB2L1, STAT5A, PRKCB, PRLR, BCL2L11, PRKCQ, MYD88, KIT (tumor)CISH, CUL2, PRKCA, STAT5B, SMAD2, CCNE1, TCEB1, IL3RA, EGFR, TCEB2, GNB2L1, HSPA6, DYNLL1, PRLR, BCL2L11, PRKCQ, GHR, EPOR, MYD88, KIT, ETV5 (normal)
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HNSC (tumor)HNSC (normal)
CISH, ERBB2, PRKCA, VHL, STAT5B, SMAD2, NFKBIA, IL3RA, CSF3R, EGFR, TCEB2, IL2RB, DYNLL1, STAT5A, PRKCB, BCL2L11, PRKCQ, GHR, EPOR, MYD88, ETV5 (tumor)CISH, CUL5, STAT3, STAT5B, CCNE1, CSF2RB, IL3RA, CSF3R, EGFR, IL2RB, GNB2L1, HSPA6, STAT5A, PRKCB, PRLR, BCL2L11, PRKCQ, GHR, MYD88, KIT, ETV5 (normal)
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KICH (tumor)KICH (normal)
CISH, CUL5, ERBB2, VHL, SMAD2, CCNE1, TCEB1, IL3RA, CSF3R, EGFR, TCEB2, GNB2L1, DYNLL1, STAT5A, PRKCB, PRLR, PRKCQ, GHR, EPOR, MYD88, ETV5 (tumor)CISH, CUL5, CUL2, ERBB2, STAT5B, SMAD2, CCNE1, NFKBIA, IL3RA, CSF3R, EGFR, TCEB2, STAT5A, PRKCB, PRLR, BCL2L11, GHR, EPOR, MYD88, KIT, ETV5 (normal)
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KIRC (tumor)KIRC (normal)
CISH, CUL2, ERBB2, VHL, STAT3, STAT5B, SMAD2, CCNE1, CSF2RB, CSF3R, EGFR, TCEB2, HSPA6, DYNLL1, STAT5A, PRKCB, PRLR, PRKCQ, GHR, EPOR, ETV5 (tumor)CISH, CUL5, CUL2, ERBB2, PRKCA, STAT3, STAT5B, SMAD2, CCNE1, NFKBIA, CSF2RB, TCEB2, IL2RB, DYNLL1, PRLR, PRKCQ, GHR, EPOR, MYD88, KIT, ETV5 (normal)
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KIRP (tumor)KIRP (normal)
CISH, CUL5, ERBB2, PRKCA, STAT5B, SMAD2, CCNE1, TCEB1, CSF2RB, IL3RA, CSF3R, TCEB2, STAT5A, PRKCB, PRLR, PRKCQ, GHR, EPOR, MYD88, KIT, ETV5 (tumor)CISH, CUL2, ERBB2, VHL, STAT3, SMAD2, CCNE1, NFKBIA, CSF2RB, CSF3R, EGFR, TCEB2, IL2RB, HSPA6, STAT5A, PRKCB, PRLR, PRKCQ, EPOR, KIT, ETV5 (normal)
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LIHC (tumor)LIHC (normal)
CISH, CUL5, CUL2, VHL, SMAD2, TCEB1, CSF2RB, IL3RA, CSF3R, EGFR, TCEB2, IL2RB, GNB2L1, STAT5A, PRKCB, PRLR, BCL2L11, PRKCQ, GHR, EPOR, KIT (tumor)CISH, CUL2, ERBB2, PRKCA, VHL, STAT3, STAT5B, SMAD2, CCNE1, NFKBIA, TCEB1, CSF3R, EGFR, GNB2L1, HSPA6, DYNLL1, BCL2L11, GHR, MYD88, KIT, ETV5 (normal)
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LUAD (tumor)LUAD (normal)
CISH, CUL5, CUL2, ERBB2, PRKCA, VHL, STAT3, CCNE1, NFKBIA, TCEB1, CSF2RB, IL3RA, CSF3R, EGFR, TCEB2, GNB2L1, DYNLL1, STAT5A, PRKCQ, GHR, MYD88 (tumor)CISH, CUL2, ERBB2, STAT3, CCNE1, NFKBIA, TCEB1, CSF2RB, IL3RA, CSF3R, EGFR, GNB2L1, DYNLL1, STAT5A, PRKCB, BCL2L11, GHR, EPOR, MYD88, KIT, ETV5 (normal)
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LUSC (tumor)LUSC (normal)
CISH, CUL5, CUL2, ERBB2, PRKCA, VHL, STAT3, NFKBIA, CSF2RB, CSF3R, IL2RB, GNB2L1, HSPA6, DYNLL1, STAT5A, PRKCB, PRKCQ, GHR, MYD88, KIT, ETV5 (tumor)CISH, CUL5, ERBB2, PRKCA, STAT3, CCNE1, NFKBIA, CSF2RB, IL3RA, CSF3R, IL2RB, HSPA6, DYNLL1, STAT5A, PRKCB, PRLR, BCL2L11, PRKCQ, EPOR, MYD88, KIT (normal)
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PRAD (tumor)PRAD (normal)
CISH, CUL5, ERBB2, PRKCA, VHL, STAT3, NFKBIA, CSF2RB, IL3RA, CSF3R, TCEB2, HSPA6, STAT5A, PRKCB, PRLR, BCL2L11, GHR, EPOR, MYD88, KIT, ETV5 (tumor)CISH, CUL5, CUL2, VHL, STAT3, STAT5B, NFKBIA, CSF2RB, IL3RA, CSF3R, TCEB2, IL2RB, HSPA6, STAT5A, PRKCB, PRLR, BCL2L11, PRKCQ, EPOR, KIT, ETV5 (normal)
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STAD (tumor)STAD (normal)
CISH, CUL5, CUL2, ERBB2, PRKCA, STAT3, STAT5B, SMAD2, CCNE1, CSF2RB, CSF3R, EGFR, TCEB2, IL2RB, GNB2L1, STAT5A, PRKCB, PRLR, GHR, MYD88, ETV5 (tumor)CISH, CUL5, PRKCA, VHL, STAT5B, SMAD2, NFKBIA, CSF2RB, IL3RA, CSF3R, EGFR, IL2RB, GNB2L1, STAT5A, PRLR, BCL2L11, PRKCQ, GHR, MYD88, KIT, ETV5 (normal)
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THCA (tumor)THCA (normal)
CISH, CUL5, ERBB2, STAT3, STAT5B, SMAD2, CCNE1, NFKBIA, CSF2RB, CSF3R, TCEB2, IL2RB, HSPA6, DYNLL1, PRKCB, BCL2L11, PRKCQ, GHR, EPOR, MYD88, KIT (tumor)CISH, CUL5, ERBB2, PRKCA, VHL, STAT5B, CCNE1, NFKBIA, TCEB1, CSF2RB, CSF3R, EGFR, TCEB2, GNB2L1, HSPA6, DYNLL1, STAT5A, PRKCB, PRKCQ, KIT, ETV5 (normal)
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TissGeneProg for CISH

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CISH
TissGeneDrug for CISH

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CISH

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0678222Breast Carcinoma13BeFree
umls:C0006142Malignant neoplasm of breast12BeFree
umls:C0596263Carcinogenesis9BeFree
umls:C2239176Liver carcinoma7BeFree
umls:C0041296Tuberculosis6BeFree,GAD
umls:C0007137Squamous cell carcinoma4BeFree
umls:C0007138Carcinoma, Transitional Cell3BeFree
umls:C0042769Virus Diseases3BeFree
umls:C0178874Tumor Progression3BeFree
umls:C0205851Germ cell tumor3BeFree
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C0677898invasive cancer3BeFree
umls:C0851140Carcinoma in situ of uterine cervix3BeFree
umls:C0003850Arteriosclerosis2BeFree
umls:C0003873Rheumatoid Arthritis2BeFree
umls:C0004153Atherosclerosis2BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2BeFree
umls:C0019693HIV Infections2BeFree
umls:C0021053Immune System Diseases2BeFree
umls:C0025202melanoma2BeFree
umls:C0026269Mitral Valve Stenosis2BeFree
umls:C0026769Multiple Sclerosis2BeFree
umls:C0028754Obesity2BeFree
umls:C0029408Degenerative polyarthritis2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0036631Seminoma2BeFree
umls:C0279671Cervical Squamous Cell Carcinoma2BeFree
umls:C0302592Cervix carcinoma2BeFree
umls:C0349458Cervical intraepithelial neoplasia grade 12BeFree
umls:C0878500Intraepithelial Neoplasia2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C1527249Colorectal Cancer2BeFree
umls:C0003469Anxiety Disorders1BeFree
umls:C0004610Bacteremia1BeFree,GAD
umls:C0004712Balo's Concentric Sclerosis1BeFree
umls:C0005684Malignant neoplasm of urinary bladder1BeFree
umls:C0005695Bladder Neoplasm1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007113Rectal Carcinoma1BeFree
umls:C0007121Bronchogenic Carcinoma1BeFree
umls:C0007124Noninfiltrating Intraductal Carcinoma1BeFree
umls:C0007847Malignant tumor of cervix1BeFree
umls:C0009324Ulcerative Colitis1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0013884Filarial Elephantiases1BeFree
umls:C0014077Leukoencephalitis, Acute Hemorrhagic1BeFree
umls:C0014378Enterovirus Infections1BeFree
umls:C0018801Heart failure1BeFree
umls:C0018802Congestive heart failure1BeFree
umls:C0019163Hepatitis B1BeFree
umls:C0019562Von Hippel-Lindau Syndrome1BeFree
umls:C0021400Influenza1BeFree
umls:C0023364Leptospirosis1BeFree
umls:C0023493Adult T-Cell Lymphoma/Leukemia1LHGDN
umls:C0023524Leukoencephalopathy, Progressive Multifocal1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0024530Malaria1CTD_human,GAD
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0027022Myeloproliferative disease1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0029134Optic Neuritis1BeFree
umls:C0029463Osteosarcoma1BeFree
umls:C0042164Uveitis1BeFree
umls:C0042373Vascular Diseases1BeFree
umls:C0085083Ovarian Hyperstimulation Syndrome1BeFree
umls:C0085605Liver Failure1BeFree
umls:C0151650Renal fibrosis1BeFree
umls:C0162820Dermatitis, Allergic Contact1CTD_human
umls:C0206659Embryonal Carcinoma1BeFree
umls:C0206698Cholangiocarcinoma1BeFree
umls:C0221228Comedone1BeFree
umls:C0238463Papillary thyroid carcinoma1BeFree
umls:C0239946Fibrosis, Liver1BeFree
umls:C0278996Cancer of Head and Neck1BeFree
umls:C0279628Adenocarcinoma Of Esophagus1BeFree
umls:C0333875High-Grade Squamous Intraepithelial Lesions1BeFree
umls:C0521158Recurrent tumor1BeFree
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C0854917Rhabdoid Tumor of the Kidney1BeFree
umls:C1112157Intrauterine infection1BeFree
umls:C1176475Ductal Carcinoma1BeFree
umls:C1292778Chronic myeloproliferative disorder1BeFree
umls:C1334177Infiltrating Cervical Carcinoma1BeFree
umls:C2745900Promyelocytic leukemia1BeFree
umls:C2921627Clinically isolated syndrome1BeFree
umls:C1834752MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding)0CTD_human