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| TissGeneSummary for DCD |
 Gene summary |
| Basic gene information | Gene symbol | DCD |
| Gene name | dermcidin | |
| Synonyms | AIDD|DCD-1|DSEP|HCAP|PIF | |
| Cytomap | UCSC genome browser: 12q13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001300854.1, NM_053283.3, | |
| Description | diffusible survival/evasion peptidepreproteolysinproteolysis inducing factorsurvival promoting peptide | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606634 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000161634 | ||
| HPRD : 07363 | ||
| Vega : OTTHUMG00000169937 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DCD | |
| BioGPS: 117159 | ||
| Pathway | NCI Pathway Interaction Database: DCD | |
| KEGG: DCD | ||
| REACTOME: DCD | ||
| Pathway Commons: DCD | ||
| Context | iHOP: DCD | |
| ligand binding site mutation search in PubMed: DCD | ||
| UCL Cancer Institute: DCD | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCASKCM | |
| Reference showing the relevant tissue of DCD | ||
| Description by TissGene annotations | Cancer gene TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for DCD |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 0.39968937 | 1.528575335 | -1.128885965 | 0.00472 | 0.008463707 |
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| TissGene-miRNA for DCD |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for DCD |
| TissGeneSNV for DCD |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E43K | SKCM | 4 |
| p.G81R | UCEC | 1 |
| p.V77A | LUAD | 1 |
| p.V94M | STAD | 1 |
| p.G69D | HNSC | 1 |
| p.L7P | STAD | 1 |
| p.R59M | SKCM | 1 |
| p.D107H | OV | 1 |
| p.E36K | SKCM | 1 |
| p.L110I | UCEC | 1 |
| p.E89K | UCEC | 1 |
| p.G69S | HNSC | 1 |
| p.R120C | SKCM | 1 |
| p.E89G | COAD | 1 |
| p.P33T | LIHC | 1 |
| p.A25S | LIHC | 1 |
| p.G79R | SKCM | 1 |
| p.L51I | BRCA | 1 |
| p.A106G | LIHC | 1 |
| p.G50E | LUAD | 1 |
| p.G72R | STAD | 1 |
| p.E23Q | LUAD | 1 |
| p.R59K | SKCM | 1 |
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| TissGeneCNV for DCD |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DCD |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for DCD |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ILK, MED26, IFIT1, IL24, FAM107A, CDC42BPB, INPP5K, EIF2B1 (tumor) | DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, FAM107A, CDC42BPB (normal) |
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| COAD (tumor) | COAD (normal) |
| DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A (tumor) | DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DCD, CUL2, UBC, YWHAZ, MDM2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, FAM107A, CDC42BPB, INPP5K, EIF2B1 (tumor) | DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A, CDC42BPB (normal) |
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| KICH (tumor) | KICH (normal) |
| DCD, CUL2, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, MED26, IFIT1, FAM107A, CDC42BPB, INPP5K, EIF2B1 (tumor) | DCD, CUL2, UBC, YWHAZ, SUMO2, MED9, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A, CDC42BPB, INPP5K, EIF2B1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DCD, CUL2, UBC, YWHAZ, MDM2, MED9, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A, CDC42BPB, INPP5K, EIF2B1 (tumor) | DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, CDC42BPB, INPP5K, EIF2B1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, SSSCA1, CD2BP2, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, FAM107A, CDC42BPB, INPP5K, EIF2B1 (tumor) | DCD, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, ILK, MED26, IFIT1, IL24, FAM107A, INPP5K, EIF2B1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A (tumor) | DCD, CUL2, UBC, YWHAZ, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, CDC42BPB, INPP5K (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, FAM107A, CDC42BPB, INPP5K, EIF2B1 (tumor) | DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, ILK, MED26, IL24, FAM107A, CDC42BPB, INPP5K, EIF2B1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A (tumor) | DCD, CUL2, UBC, YWHAZ, SUMO2, MED9, KIAA0101, CUL3, SSSCA1, CD2BP2, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A, CDC42BPB, INPP5K, EIF2B1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A (tumor) | DCD, CUL2, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A, CDC42BPB, EIF2B1 (normal) |
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| STAD (tumor) | STAD (normal) |
| DCD, CUL2, UBC, YWHAZ, MDM2, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A (tumor) | DCD, CUL2, UBC, YWHAZ, SUMO2, MED9, KIAA0101, CUL4B, CUL3, SSSCA1, CD2BP2, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A, CDC42BPB, INPP5K (normal) |
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| THCA (tumor) | THCA (normal) |
| DCD, CUL2, UBC, YWHAZ, SUMO2, MED9, KIAA0101, CUL4B, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A, CDC42BPB, EIF2B1 (tumor) | DCD, UBC, MDM2, SUMO2, MED9, KIAA0101, CUL4B, SSSCA1, CD2BP2, COPS5, TNFRSF14, ARRB2, VDAC1, ILK, MED26, IFIT1, IL24, FAM107A, CDC42BPB, INPP5K, EIF2B1 (normal) |
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| TissGeneProg for DCD |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DCD |
| TissGeneDrug for DCD |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DCD |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 8 | BeFree,GAD |
| umls:C0006625 | Cachexia | 6 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
| umls:C0600139 | Prostate carcinoma | 3 | BeFree |
| umls:C0011757 | Developmental Coordination Disorder | 2 | BeFree |
| umls:C0023903 | Liver neoplasms | 2 | BeFree,CTD_human |
| umls:C0003130 | Anoxia | 1 | LHGDN |
| umls:C0011615 | Dermatitis, Atopic | 1 | LHGDN |
| umls:C0023646 | Lichen Planus | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0029456 | Osteoporosis | 1 | GAD |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0037274 | Dermatologic disorders | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0264716 | Chronic heart failure | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0877373 | Advanced cancer | 1 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 1 | BeFree |
| umls:C1567664 | Warm Ischemia | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
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