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| TissGeneSummary for SENP8 |
 Gene summary |
| Basic gene information | Gene symbol | SENP8 |
| Gene name | SUMO/sentrin specific peptidase family member 8 | |
| Synonyms | DEN1|NEDP1|PRSC2 | |
| Cytomap | UCSC genome browser: 15q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001166340.1, NM_001172109.1,NM_001172110.1,NM_001172111.1,NM_145204.3, | |
| Description | NEDD8 specific-protease cysteine 2NEDD8-specific protease 1SUMO sentrin specific protease family member 8deneddylase 1deneddylase-1protease, cysteine 2sentrin-specific protease 8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608659 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166192 | ||
| HPRD : 09784 | ||
| Vega : OTTHUMG00000133441 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SENP8 | |
| BioGPS: 123228 | ||
| Pathway | NCI Pathway Interaction Database: SENP8 | |
| KEGG: SENP8 | ||
| REACTOME: SENP8 | ||
| Pathway Commons: SENP8 | ||
| Context | iHOP: SENP8 | |
| ligand binding site mutation search in PubMed: SENP8 | ||
| UCL Cancer Institute: SENP8 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTGCT | |
| Reference showing the relevant tissue of SENP8 | ||
| Description by TissGene annotations | Protective TissGene in OS Cancer gene Have significant anti-correlated miRNA TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SENP8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| ESCA | -1.282020094 | -0.145456457 | -1.136563636 | 0.00127 | 0.017222439 |
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| TissGene-miRNA for SENP8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-9-5p | MIMAT0000441 | 0.012 | -0.32 | 60 |
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| TissGeneMut for SENP8 |
| TissGeneSNV for SENP8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S120F | PAAD | 1 |
| p.H128Y | SKCM | 1 |
| p.L27F | SKCM | 1 |
| p.H45Y | SKCM | 1 |
| p.Y166F | KIRP | 1 |
| p.R14W | UCEC | 1 |
| p.T59I | DLBC | 1 |
| p.R14W | ESCA | 1 |
| p.E57K | BRCA | 1 |
| p.Q110X | SKCM | 1 |
| p.H30R | STAD | 1 |
| p.N159T | COAD | 1 |
| p.C175* | OV | 1 |
| p.K212N | ESCA | 1 |
| p.G144* | UCEC | 1 |
| p.D145N | BLCA | 1 |
| p.Q43X | KIRC | 1 |
| p.E134D | BLCA | 1 |
| p.L205I | PAAD | 1 |
| p.Q110* | SKCM | 1 |
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| TissGeneCNV for SENP8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SENP8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A1LA-01A | SMAD3-SENP8 | CDS-5UTR | Chr15:67358698 | Chr15:72431918 |
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| TissGeneNet for SENP8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| COAD (tumor) | COAD (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| KICH (tumor) | KICH (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| STAD (tumor) | STAD (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| THCA (tumor) | THCA (normal) |
| SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (tumor) | SENP8, CUL2, NEDD8, UBB, PLA2G2A, RPL11 (normal) |
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| TissGeneProg for SENP8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SENP8 |
| TissGeneDrug for SENP8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SENP8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011311 | Dengue Fever | 31 | BeFree |
| umls:C0019100 | Severe Dengue | 5 | BeFree |
| umls:C0019104 | Hemorrhagic Fevers, Viral | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
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