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| TissGeneSummary for C1orf87 |
 Gene summary |
| Basic gene information | Gene symbol | C1orf87 |
| Gene name | chromosome 1 open reading frame 87 | |
| Synonyms | CREF | |
| Cytomap | UCSC genome browser: 1p32.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_152377.2, | |
| Description | carcinoma-related EF-hand proteinuncharacterized protein C1orf87 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000162598 | ||
| HPRD : 11338 | ||
| Vega : OTTHUMG00000008992 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C1orf87 | |
| BioGPS: 127795 | ||
| Pathway | NCI Pathway Interaction Database: C1orf87 | |
| KEGG: C1orf87 | ||
| REACTOME: C1orf87 | ||
| Pathway Commons: C1orf87 | ||
| Context | iHOP: C1orf87 | |
| ligand binding site mutation search in PubMed: C1orf87 | ||
| UCL Cancer Institute: C1orf87 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of C1orf87 | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C1orf87 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.518563296 | -0.485811296 | -2.032752 | 1.57E-09 | 9.53E-09 |
| KIRC | -2.142786463 | -0.743753129 | -1.399033333 | 2.24E-10 | 7.66E-10 |
| LUAD | 0.06277029 | 3.753768566 | -3.690998276 | 5.66E-14 | 5.12E-13 |
| LUSC | -0.988670041 | 3.667098586 | -4.655768627 | 8.64E-21 | 1.12E-19 |
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| TissGene-miRNA for C1orf87 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C1orf87 |
| TissGeneSNV for C1orf87 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R333C | UCEC | 2 |
| p.R333C | SKCM | 2 |
| p.E374K | SKCM | 2 |
| p.S334L | SKCM | 2 |
| p.S3* | LUSC | 1 |
| p.E374G | STAD | 1 |
| p.A524D | THYM | 1 |
| p.A272E | ESCA | 1 |
| p.S530L | SKCM | 1 |
| p.S388F | SKCM | 1 |
| p.N193S | SKCM | 1 |
| p.G531V | LUAD | 1 |
| p.A311S | LUAD | 1 |
| p.W147X | STAD | 1 |
| p.Q151K | THCA | 1 |
| p.S517I | STAD | 1 |
| p.K403E | COAD | 1 |
| p.E16D | HNSC | 1 |
| p.A58T | UCEC | 1 |
| p.W257R | LIHC | 1 |
| p.S192F | SKCM | 1 |
| p.A273S | COAD | 1 |
| p.L198I | READ | 1 |
| p.Q519E | BLCA | 1 |
| p.L213I | UCEC | 1 |
| p.P462S | STAD | 1 |
| p.W147* | STAD | 1 |
| p.K402N | SKCM | 1 |
| p.V153M | SKCM | 1 |
| p.A404S | READ | 1 |
| p.P340L | SKCM | 1 |
| p.Q519E | HNSC | 1 |
| p.R182T | LUAD | 1 |
| p.S441T | HNSC | 1 |
| p.L305F | ACC | 1 |
| p.S530L | UCEC | 1 |
| p.N97K | PRAD | 1 |
| p.R329Q | SKCM | 1 |
| p.D368H | PAAD | 1 |
| p.L391F | OV | 1 |
| p.E430K | CESC | 1 |
| p.G531A | LUAD | 1 |
| p.L355M | COAD | 1 |
| p.R541Q | UCEC | 1 |
| p.R302G | STAD | 1 |
| p.Q457H | ACC | 1 |
| p.Q93K | LUAD | 1 |
| p.R500* | ACC | 1 |
| p.S456F | PRAD | 1 |
| p.S517R | CHOL | 1 |
| p.K271N | HNSC | 1 |
| p.E331K | LUSC | 1 |
| p.E38D | HNSC | 1 |
| p.Q47X | LIHC | 1 |
| p.R329Q | STAD | 1 |
| p.I22S | UCEC | 1 |
| p.E499K | SKCM | 1 |
| p.W474C | HNSC | 1 |
| p.D522E | PRAD | 1 |
| p.S166R | LIHC | 1 |
| p.E382* | BLCA | 1 |
| p.E280K | LUSC | 1 |
| p.D322E | SARC | 1 |
| p.P116S | SKCM | 1 |
| p.D206Y | BLCA | 1 |
| p.G138V | LIHC | 1 |
| p.S168R | LGG | 1 |
| p.W377C | LUAD | 1 |
| p.S530L | READ | 1 |
| p.R500Q | SKCM | 1 |
| p.N91S | SKCM | 1 |
| p.Q151L | ESCA | 1 |
| p.R220C | COAD | 1 |
| p.G23E | SKCM | 1 |
| p.E38K | SKCM | 1 |
| p.E226* | UCEC | 1 |
| p.E85K | KIRC | 1 |
| p.R526S | LUAD | 1 |
| p.E482G | SKCM | 1 |
| p.K243N | BLCA | 1 |
| p.T77A | UCS | 1 |
| p.P407S | SKCM | 1 |
| p.G211E | OV | 1 |
| p.D12N | SKCM | 1 |
| p.E306K | SKCM | 1 |
| p.R503H | UCEC | 1 |
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| TissGeneCNV for C1orf87 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C1orf87 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | T20169 | ANP32A-C1orf87 | chr15:69071952 | chr1:60458727 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A1R7-01A | OSBPL9-C1orf87 | Out-of-frame | Chr1:52117713 | Chr1:60476128 |
| TCGAfusionPortal | PRADA | OV | TCGA-24-1553-01A | ASH1L-C1orf87 | Out-of-frame | Chr1:155349834 | Chr1:60521110 |
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| TissGeneNet for C1orf87 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for C1orf87 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C1orf87 |
| TissGeneDrug for C1orf87 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C1orf87 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0005586 | Bipolar Disorder | 3 | GAD |
| umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
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