 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for SIRPD |
 Gene summary |
| Basic gene information | Gene symbol | SIRPD |
| Gene name | signal-regulatory protein delta | |
| Synonyms | PTPNS1L2|dJ576H24.4 | |
| Cytomap | UCSC genome browser: 20p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_178460.2, | |
| Description | SIRP-deltaprotein tyrosine phosphatase non-receptor type substrate 1-like 2protein tyrosine phosphatase, non-receptor type substrate 1-like 2 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000125900 | ||
| HPRD : 17931 | ||
| Vega : OTTHUMG00000031674 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SIRPD | |
| BioGPS: 128646 | ||
| Pathway | NCI Pathway Interaction Database: SIRPD | |
| KEGG: SIRPD | ||
| REACTOME: SIRPD | ||
| Pathway Commons: SIRPD | ||
| Context | iHOP: SIRPD | |
| ligand binding site mutation search in PubMed: SIRPD | ||
| UCL Cancer Institute: SIRPD | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SIRPD | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for SIRPD |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -0.024573507 | -1.188962396 | 1.164388889 | 1.09E-15 | 5.73E-15 |
| LUAD | -0.372274178 | 1.439548236 | -1.811822414 | 9.86E-23 | 2.91E-21 |
| LUSC | -0.789788377 | 1.556260643 | -2.34604902 | 5.93E-30 | 2.62E-28 |
| Top |
| TissGene-miRNA for SIRPD |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for SIRPD |
| TissGeneSNV for SIRPD |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.F120L | LIHC | 2 |
| p.S6F | SKCM | 2 |
| p.V180I | LUAD | 1 |
| p.E172Q | HNSC | 1 |
| p.R133W | COAD | 1 |
| p.R72W | UCEC | 1 |
| p.E172K | SKCM | 1 |
| p.E88Q | BLCA | 1 |
| p.P2L | LUAD | 1 |
| p.K197N | LIHC | 1 |
| p.P182T | LGG | 1 |
| p.S168L | STAD | 1 |
| p.F100Y | SKCM | 1 |
| p.H161D | SKCM | 1 |
| p.E106Q | CHOL | 1 |
| p.E172D | BLCA | 1 |
| p.H160Q | LUAD | 1 |
| p.E88K | SKCM | 1 |
| p.E22K | SKCM | 1 |
| p.E45K | SKCM | 1 |
| p.E106K | CESC | 1 |
| p.R72Q | LUAD | 1 |
| p.R133P | LUAD | 1 |
| p.R187Q | GBM | 1 |
| p.E128K | SKCM | 1 |
| p.F83S | KIRC | 1 |
| p.G60E | SKCM | 1 |
| p.R103C | BLCA | 1 |
| p.E88K | SARC | 1 |
| p.E106* | BLCA | 1 |
| p.K73I | LUSC | 1 |
| p.X198Q | READ | 1 |
| p.K79E | UCEC | 1 |
| p.R103H | STAD | 1 |
| p.N149T | SKCM | 1 |
| p.N77S | UCEC | 1 |
| p.V118M | HNSC | 1 |
| p.P84S | SKCM | 1 |
| p.R133L | LUAD | 1 |
| p.L194F | ACC | 1 |
| p.R187G | SKCM | 1 |
| p.G67E | SKCM | 1 |
| p.N82D | UCEC | 1 |
| p.V180I | COAD | 1 |
| Top |
| TissGeneCNV for SIRPD |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for SIRPD |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for SIRPD |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| SIRPD, S100A9 (tumor) | SIRPD, S100A9 (normal) |
 |  |
| Top |
| TissGeneProg for SIRPD |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for SIRPD |
| TissGeneDrug for SIRPD |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for SIRPD |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |