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| TissGeneSummary for CST9 |
 Gene summary |
| Basic gene information | Gene symbol | CST9 |
| Gene name | cystatin 9 (testatin) | |
| Synonyms | CLM|CTES7A | |
| Cytomap | UCSC genome browser: 20p11.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001008693.2, | |
| Description | cystatin-9cystatin-like molecule | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000173335 | ||
| HPRD : 16768 | ||
| Vega : OTTHUMG00000032076 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CST9 | |
| BioGPS: 128822 | ||
| Pathway | NCI Pathway Interaction Database: CST9 | |
| KEGG: CST9 | ||
| REACTOME: CST9 | ||
| Pathway Commons: CST9 | ||
| Context | iHOP: CST9 | |
| ligand binding site mutation search in PubMed: CST9 | ||
| UCL Cancer Institute: CST9 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Breast | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCA | |
| Reference showing the relevant tissue of CST9 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CST9 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -1.518344487 | 1.062352388 | -2.580696875 | 9.87E-09 | 7.53E-08 |
| KICH | -1.518344487 | 1.201891513 | -2.720236 | 1.09E-09 | 6.75E-09 |
| KIRC | -1.468629209 | 0.730877735 | -2.199506944 | 2.73E-22 | 2.52E-21 |
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| TissGene-miRNA for CST9 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CST9 |
| TissGeneSNV for CST9 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E107K | SKCM | 2 |
| p.V91M | UCEC | 1 |
| p.E32K | SKCM | 1 |
| p.E120K | UCEC | 1 |
| p.R87* | MESO | 1 |
| p.W77* | BLCA | 1 |
| p.R78S | LUAD | 1 |
| p.T57I | LUAD | 1 |
| p.R155M | COAD | 1 |
| p.G127S | LGG | 1 |
| p.M35I | GBM | 1 |
| p.D156Y | LUAD | 1 |
| p.C139R | ACC | 1 |
| p.R72H | ACC | 1 |
| p.P154T | LUAD | 1 |
| p.Q61H | LGG | 1 |
| p.G145D | BRCA | 1 |
| p.L121M | LUAD | 1 |
| p.N112S | COAD | 1 |
| p.G147R | GBM | 1 |
| p.G37C | LUAD | 1 |
| p.E79X | THYM | 1 |
| p.P114S | SKCM | 1 |
| p.A148E | LUAD | 1 |
| p.G158E | SKCM | 1 |
| p.S129I | ACC | 1 |
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| TissGeneCNV for CST9 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CST9 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CST9 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| COAD (tumor) | COAD (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| KICH (tumor) | KICH (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| STAD (tumor) | STAD (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| THCA (tumor) | THCA (normal) |
| CST9, IRF8 (tumor) | CST9, IRF8 (normal) |
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| TissGeneProg for CST9 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CST9 |
| TissGeneDrug for CST9 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CST9 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0001925 | Albuminuria | 1 | GAD |
| umls:C0004623 | Bacterial Infections | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0022658 | Kidney Diseases | 1 | GAD |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C1368683 | Epithelioma | 1 | BeFree |
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