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| TissGeneSummary for CHODL |
 Gene summary |
| Basic gene information | Gene symbol | CHODL |
| Gene name | chondrolectin | |
| Synonyms | C21orf68|MT75 | |
| Cytomap | UCSC genome browser: 21q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001204174.1, NM_001204175.1,NM_001204176.1,NM_001204177.1,NM_001204178.1, NM_024944.2, | |
| Description | transmembrane protein MT75 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607247 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000154645 | ||
| HPRD : 06261 | ||
| Vega : OTTHUMG00000074519 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CHODL | |
| BioGPS: 140578 | ||
| Pathway | NCI Pathway Interaction Database: CHODL | |
| KEGG: CHODL | ||
| REACTOME: CHODL | ||
| Pathway Commons: CHODL | ||
| Context | iHOP: CHODL | |
| ligand binding site mutation search in PubMed: CHODL | ||
| UCL Cancer Institute: CHODL | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of CHODL | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CHODL |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -0.959151917 | 0.898126154 | -1.85727807 | 1.83E-15 | 9.84E-15 |
| COAD | -1.443438826 | 1.60016502 | -3.043603846 | 7.75E-10 | 8.80E-09 |
| KIRP | -1.700498682 | 1.946066943 | -3.646565625 | 3.21E-14 | 7.27E-13 |
| KICH | -2.523290057 | 1.970009943 | -4.4933 | 2.28E-15 | 5.03E-14 |
| STAD | -1.824333057 | 1.299210693 | -3.12354375 | 6.97E-09 | 3.65E-07 |
| THCA | -0.929336023 | 0.48619618 | -1.415532203 | 2.09E-13 | 2.08E-12 |
| KIRC | -0.778862224 | 1.970244721 | -2.749106944 | 3.31E-16 | 1.83E-15 |
| LUSC | 1.56488508 | -0.914846292 | 2.479731373 | 4.54E-10 | 1.61E-09 |
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| TissGene-miRNA for CHODL |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CHODL |
| TissGeneSNV for CHODL |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E136K | SKCM | 2 |
| p.E76Q | HNSC | 1 |
| p.P189L | LUAD | 1 |
| p.S95F | SKCM | 1 |
| p.L182P | COAD | 1 |
| p.G56S | SKCM | 1 |
| p.S53I | STAD | 1 |
| p.R51X | SKCM | 1 |
| p.S257C | BLCA | 1 |
| p.H149Y | SKCM | 1 |
| p.E56K | LUAD | 1 |
| p.Q187* | SKCM | 1 |
| p.E235* | LUAD | 1 |
| p.Q128K | SKCM | 1 |
| p.R51* | SKCM | 1 |
| p.L217P | ESCA | 1 |
| p.P174S | SKCM | 1 |
| p.D67Y | COAD | 1 |
| p.G56C | READ | 1 |
| p.P145S | SKCM | 1 |
| p.D167N | SKCM | 1 |
| p.M42I | UCEC | 1 |
| p.A112S | COAD | 1 |
| p.I231L | SKCM | 1 |
| p.G140R | SARC | 1 |
| p.G97C | ESCA | 1 |
| p.G124R | SKCM | 1 |
| p.S63I | LUAD | 1 |
| p.V30L | LUAD | 1 |
| p.W124X | SKCM | 1 |
| p.G113D | UCS | 1 |
| p.K251E | GBM | 1 |
| p.S22R | SKCM | 1 |
| p.S54F | SKCM | 1 |
| p.W80X | SKCM | 1 |
| p.G93W | LGG | 1 |
| p.T196I | LIHC | 1 |
| p.S86P | SKCM | 1 |
| p.Q187X | SKCM | 1 |
| p.E47D | UCEC | 1 |
| p.C115W | STAD | 1 |
| p.K230T | UCEC | 1 |
| p.K29R | ESCA | 1 |
| p.W165* | SKCM | 1 |
| p.E72D | UCS | 1 |
| p.W104X | KIRC | 1 |
| p.E235K | SKCM | 1 |
| p.G200E | SKCM | 1 |
| p.N106I | SKCM | 1 |
| p.R10X | COAD | 1 |
| p.S127P | SKCM | 1 |
| p.L182Q | LUAD | 1 |
| p.W121* | SKCM | 1 |
| p.P186S | SKCM | 1 |
| p.E95K | SKCM | 1 |
| p.S63R | SKCM | 1 |
| p.P90L | SKCM | 1 |
| p.L195V | BLCA | 1 |
| p.G97S | SKCM | 1 |
| p.P155S | SARC | 1 |
| p.I190L | SKCM | 1 |
| p.P186S | LUAD | 1 |
| p.E191X | COAD | 1 |
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| TissGeneCNV for CHODL |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CHODL |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW511581 | C11orf75-CHODL | chr11:93211926 | chr21:19437070 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AC-A2QH-01A | KIAA1109-CHODL | NA | Chr4:123188113 | Chr21:19613305 |
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| TissGeneNet for CHODL |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CHODL |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CHODL |
| TissGeneDrug for CHODL |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CHODL |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0026847 | Spinal Muscular Atrophy | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C1516170 | Cancer Cell Growth | 1 | BeFree |
| umls:C2267227 | Bulimia Nervosa | 1 | GWASCAT |
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