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| TissGeneSummary for ELAVL3 |
 Gene summary |
| Basic gene information | Gene symbol | ELAVL3 |
| Gene name | ELAV like neuron-specific RNA binding protein 3 | |
| Synonyms | HUC|HUCL|PLE21 | |
| Cytomap | UCSC genome browser: 19p13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001420.3, NM_032281.2, | |
| Description | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)ELAV-like protein 3Hu antigen Chu-antigen Cparaneoplastic cerebellar degeneration-associated antigenparaneoplastic limbic encephalitis antigen 21 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603458 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000196361 | ||
| HPRD : 16024 | ||
| Vega : OTTHUMG00000182030 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ELAVL3 | |
| BioGPS: 1995 | ||
| Pathway | NCI Pathway Interaction Database: ELAVL3 | |
| KEGG: ELAVL3 | ||
| REACTOME: ELAVL3 | ||
| Pathway Commons: ELAVL3 | ||
| Context | iHOP: ELAVL3 | |
| ligand binding site mutation search in PubMed: ELAVL3 | ||
| UCL Cancer Institute: ELAVL3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of ELAVL3 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ELAVL3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | 0.227065509 | 1.566388586 | -1.339323077 | 1.32E-06 | 9.13E-06 |
| COAD | -1.564076799 | 1.129277048 | -2.693353846 | 1.30E-10 | 1.80E-09 |
| STAD | -1.217325116 | 0.197034259 | -1.414359375 | 0.00389 | 0.015877695 |
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| TissGene-miRNA for ELAVL3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-107 | MIMAT0000104 | 0.025 | -0.3 | 56 |
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| TissGeneMut for ELAVL3 |
| TissGeneSNV for ELAVL3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D265N | UCEC | 2 |
| p.G149D | SKCM | 2 |
| p.S254L | SKCM | 2 |
| p.A263T | SARC | 1 |
| p.G149S | SKCM | 1 |
| p.A203V | UCEC | 1 |
| p.G102D | SKCM | 1 |
| p.P191L | SARC | 1 |
| p.G347D | SKCM | 1 |
| p.T210M | PAAD | 1 |
| p.N290S | SKCM | 1 |
| p.G248D | SKCM | 1 |
| p.V330M | COAD | 1 |
| p.G131E | SKCM | 1 |
| p.T333A | LIHC | 1 |
| p.G278C | LUAD | 1 |
| p.A271T | LUAD | 1 |
| p.G131R | STAD | 1 |
| p.A257S | UCEC | 1 |
| p.E140K | SKCM | 1 |
| p.W301* | BLCA | 1 |
| p.S260L | ESCA | 1 |
| p.L6P | HNSC | 1 |
| p.R317C | UCEC | 1 |
| p.A271E | LUSC | 1 |
| p.S146Y | LUAD | 1 |
| p.D94N | LUSC | 1 |
| p.A282T | STAD | 1 |
| p.G131W | BLCA | 1 |
| p.I183M | BLCA | 1 |
| p.A194T | READ | 1 |
| p.R72Q | STAD | 1 |
| p.G19S | STAD | 1 |
| p.S121P | UCEC | 1 |
| p.R150H | STAD | 1 |
| p.R172H | SKCM | 1 |
| p.G347S | SKCM | 1 |
| p.R123W | BLCA | 1 |
| p.A343T | STAD | 1 |
| p.V2I | UCEC | 1 |
| p.R236H | HNSC | 1 |
| p.D64G | LIHC | 1 |
| p.Y45H | KIRP | 1 |
| p.E180K | SKCM | 1 |
| p.G60S | LUAD | 1 |
| p.R155C | UCEC | 1 |
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| TissGeneCNV for ELAVL3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ELAVL3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ELAVL3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| COAD (tumor) | COAD (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| KICH (tumor) | KICH (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| STAD (tumor) | STAD (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| THCA (tumor) | THCA (normal) |
| ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (tumor) | ELAVL3, SUMO1, MAST1, CDC37, EWSR1, NOS3, SIRT1, A2M, ECSIT, RNF32, ELAVL2 (normal) |
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| TissGeneProg for ELAVL3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ELAVL3 |
| TissGeneDrug for ELAVL3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ELAVL3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 4 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 4 | BeFree |
| umls:C0007138 | Carcinoma, Transitional Cell | 3 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0004509 | Azoospermia | 1 | BeFree |
| umls:C0005695 | Bladder Neoplasm | 1 | BeFree |
| umls:C0014070 | Encephalomyelitis | 1 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C2145472 | Urothelial Carcinoma | 1 | BeFree |
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