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| TissGeneSummary for EMP1 |
 Gene summary |
| Basic gene information | Gene symbol | EMP1 |
| Gene name | epithelial membrane protein 1 | |
| Synonyms | CL-20|EMP-1|TMP | |
| Cytomap | UCSC genome browser: 12p12.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001423.2, | |
| Description | tumor-associated membrane protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602333 | |
| HGNC : HGNC | ||
| HPRD : 11892 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_EMP1 | |
| BioGPS: 2012 | ||
| Pathway | NCI Pathway Interaction Database: EMP1 | |
| KEGG: EMP1 | ||
| REACTOME: EMP1 | ||
| Pathway Commons: EMP1 | ||
| Context | iHOP: EMP1 | |
| ligand binding site mutation search in PubMed: EMP1 | ||
| UCL Cancer Institute: EMP1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusSoft tissue | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCASARC | |
| Reference showing the relevant tissue of EMP1 | ||
| Description by TissGene annotations | Fused withTSGene Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0008219 | cell death | 12107182 | GO:0032060 | bleb assembly | 12107182 | GO:0008219 | cell death | 12107182 | GO:0032060 | bleb assembly | 12107182 |
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| TissGeneExp for EMP1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -1.56551917 | 1.00990483 | -2.575424 | 7.80E-11 | 6.18E-10 |
| LUAD | 0.74826552 | 1.88486552 | -1.1366 | 1.33E-08 | 5.86E-08 |
| HNSC | 1.854689016 | 4.316814598 | -2.462125581 | 3.16E-09 | 4.42E-08 |
| COAD | 0.24739483 | 1.701290984 | -1.453896154 | 4.19E-07 | 2.56E-06 |
| BRCA | 0.970165883 | 2.531229918 | -1.561064035 | 1.26E-29 | 1.64E-28 |
| BLCA | 0.480502725 | 2.609865883 | -2.129363158 | 0.000145 | 0.001479266 |
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| TissGene-miRNA for EMP1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-29a-3p | MIMAT0000086 | 0.045 | -0.27 | 56 |
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| TissGeneMut for EMP1 |
| TissGeneSNV for EMP1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V149I | HNSC | 1 |
| p.F87V | SKCM | 1 |
| p.F141L | READ | 1 |
| p.Q127X | ACC | 1 |
| p.C49* | LIHC | 1 |
| p.K156N | UCEC | 1 |
| p.F87L | CESC | 1 |
| p.S98* | CESC | 1 |
| p.R94W | LGG | 1 |
| p.Y116C | COAD | 1 |
| p.R155I | UCEC | 1 |
| p.A25G | LGG | 1 |
| p.Y120N | SKCM | 1 |
| p.S57N | COAD | 1 |
| p.S31Y | LIHC | 1 |
| p.G131S | STAD | 1 |
| p.T33M | STAD | 1 |
| p.T45A | BRCA | 1 |
| p.Q127* | ACC | 1 |
| p.M1K | HNSC | 1 |
| p.C49X | LIHC | 1 |
| p.F67L | CESC | 1 |
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| TissGeneCNV for EMP1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for EMP1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AK309521 | DARC-EMP1 | chr1:159176039 | chr12:13349755 | |
| Chimerdb3.0 | ChiTaRs | NA | AI355548 | IRF2-EMP1 | chr4:185309119 | chr12:13369520 | |
| Chimerdb3.0 | ChiTaRs | NA | BM785881 | EMP1-DNAJA2 | chr12:13369379 | chr16:46993227 | |
| Chimerdb3.0 | ChiTaRs | NA | BG315010 | EMP1-TTC28-AS1 | chr12:13368917 | chr22:28378409 | |
| Chimerdb3.0 | ChiTaRs | NA | BE005032 | EMP1-EMP1 | chr12:13368462 | chr12:13368667 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OM-01A | RCC1-EMP1 | 5'UTR-5'UTR | chr1:28834672 | chr12:13364402 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-GI-A2C9-01A | EMP1-ETV6 | 5UTR-CDS | Chr12:13349806 | Chr12:12043875 |
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| TissGeneNet for EMP1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for EMP1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for EMP1 |
| TissGeneDrug for EMP1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for EMP1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0042029 | Urinary tract infection | 5 | BeFree |
| umls:C1535939 | Pneumocystis jiroveci pneumonia | 4 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0004659 | Bacteriuria | 2 | BeFree |
| umls:C0006118 | Brain Neoplasms | 2 | BeFree |
| umls:C0019693 | HIV Infections | 2 | BeFree |
| umls:C0032285 | Pneumonia | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
| umls:C3714636 | Pneumonitis | 2 | BeFree |
| umls:C0000786 | Spontaneous abortion | 1 | CTD_human |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007785 | Cerebral Infarction | 1 | BeFree |
| umls:C0010200 | Coughing | 1 | BeFree |
| umls:C0010692 | Cystitis | 1 | BeFree |
| umls:C0013371 | Shigella Infections | 1 | BeFree |
| umls:C0014599 | Epithelial hyperplasia | 1 | BeFree |
| umls:C0018203 | Chronic granulomatous disease | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0026946 | Mycoses | 1 | BeFree |
| umls:C0027430 | Nasal Polyps | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0677936 | Refractory cancer | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0751778 | Myoclonic Epilepsies, Progressive | 1 | BeFree |
| umls:C0917798 | Cerebral Ischemia | 1 | BeFree |
| umls:C1827377 | Slow acetylator due to N-acetyltransferase enzyme variant | 1 | BeFree |
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