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| TissGeneSummary for FMO2 |
 Gene summary |
| Basic gene information | Gene symbol | FMO2 |
| Gene name | flavin containing monooxygenase 2 (non-functional) | |
| Synonyms | FMO1B1 | |
| Cytomap | UCSC genome browser: 1q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001301347.1, NM_001460.4, | |
| Description | FMO, pulmonarydimethylaniline monooxygenase [N-oxide-forming] 2dimethylaniline oxidase 2pulmonary flavin-containing monooxygenase 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603955 | |
| HGNC : HGNC | ||
| HPRD : 04903 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FMO2 | |
| BioGPS: 2327 | ||
| Pathway | NCI Pathway Interaction Database: FMO2 | |
| KEGG: FMO2 | ||
| REACTOME: FMO2 | ||
| Pathway Commons: FMO2 | ||
| Context | iHOP: FMO2 | |
| ligand binding site mutation search in PubMed: FMO2 | ||
| UCL Cancer Institute: FMO2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC | |
| Reference showing the relevant tissue of FMO2 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006082 | organic acid metabolic process | 11744609 | GO:0006739 | NADP metabolic process | 11744609 | GO:0006805 | xenobiotic metabolic process | 11744609 | GO:0009404 | toxin metabolic process | 11744609 | GO:0017144 | drug metabolic process | 11744609 | GO:0070995 | NADPH oxidation | 15144220 | GO:0006082 | organic acid metabolic process | 11744609 | GO:0006739 | NADP metabolic process | 11744609 | GO:0006805 | xenobiotic metabolic process | 11744609 | GO:0009404 | toxin metabolic process | 11744609 | GO:0017144 | drug metabolic process | 11744609 | GO:0070995 | NADPH oxidation | 15144220 |
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| TissGeneExp for FMO2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 0.565981399 | 3.014697024 | -2.448715625 | 1.91E-05 | 7.55E-05 |
| KICH | -2.540002726 | 3.505565274 | -6.045568 | 2.36E-16 | 6.94E-15 |
| THCA | -1.256787404 | 1.937415985 | -3.19420339 | 1.47E-19 | 5.09E-18 |
| BRCA | 1.77874187 | 5.889356782 | -4.110614912 | 8.92E-47 | 4.68E-45 |
| HNSC | 0.256490483 | 5.568334669 | -5.311844186 | 7.89E-19 | 4.47E-16 |
| LUAD | 3.31668086 | 6.649503274 | -3.332822414 | 1.64E-30 | 2.30E-28 |
| LUSC | 2.591425823 | 6.601072881 | -4.009647059 | 7.96E-25 | 1.68E-23 |
| LIHC | -0.954030726 | 0.733495274 | -1.687526 | 1.55E-07 | 1.05E-06 |
| COAD | -2.143735188 | -0.368431342 | -1.775303846 | 0.000472 | 0.001466882 |
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| TissGene-miRNA for FMO2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-7153-5p | MIMAT0028216 | 0.015 | -0.28 | 78 |
| ACC | hsa-miR-7153-5p | MIMAT0028216 | 0.015 | -0.28 | 78 |
| UCS | hsa-miR-421 | MIMAT0003339 | 0.023 | -0.31 | 56 |
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| TissGeneMut for FMO2 |
| TissGeneSNV for FMO2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P457S | SKCM | 4 |
| p.R249Q | SKCM | 2 |
| p.R240C | SKCM | 2 |
| p.G193E | SKCM | 2 |
| p.R186C | LUAD | 2 |
| p.K44_splice | LUSC | 1 |
| p.E65* | BRCA | 1 |
| p.R249X | COAD | 1 |
| p.E45D | READ | 1 |
| p.S351L | PRAD | 1 |
| p.G38E | SKCM | 1 |
| p.E226K | SKCM | 1 |
| p.V324G | UCEC | 1 |
| p.G466R | CESC | 1 |
| p.G270S | LUAD | 1 |
| p.N321K | KIRP | 1 |
| p.E226K | CESC | 1 |
| p.G38E | HNSC | 1 |
| p.G168S | SKCM | 1 |
| p.M242I | LUAD | 1 |
| p.D36G | COAD | 1 |
| p.P358S | SARC | 1 |
| p.W41C | BRCA | 1 |
| p.E32Q | BLCA | 1 |
| p.L384H | PAAD | 1 |
| p.S451T | LIHC | 1 |
| p.E314K | BLCA | 1 |
| p.S334F | SKCM | 1 |
| p.G370A | SKCM | 1 |
| p.R223H | STAD | 1 |
| p.R114I | UCEC | 1 |
| p.F333L | READ | 1 |
| p.S137R | BLCA | 1 |
| p.P79S | SKCM | 1 |
| p.K97N | UCEC | 1 |
| p.L243F | PRAD | 1 |
| p.T60I | BLCA | 1 |
| p.A208T | ACC | 1 |
| p.V59I | LUAD | 1 |
| p.R174H | COAD | 1 |
| p.G270D | SKCM | 1 |
| p.P179L | SKCM | 1 |
| p.R240C | UCEC | 1 |
| p.W254* | SKCM | 1 |
| p.A208S | STAD | 1 |
| p.A445V | STAD | 1 |
| p.F119L | UCEC | 1 |
| p.A142T | UCEC | 1 |
| p.W219R | LUSC | 1 |
| p.W254L | LUAD | 1 |
| p.P230L | SKCM | 1 |
| p.R291C | COAD | 1 |
| p.R244H | PAAD | 1 |
| p.G181A | BLCA | 1 |
| p.S195L | COAD | 1 |
| p.R387H | UVM | 1 |
| p.R92K | BLCA | 1 |
| p.R223S | KIRC | 1 |
| p.F81S | DLBC | 1 |
| p.L459Q | SARC | 1 |
| p.D323H | LUAD | 1 |
| p.G168D | LUSC | 1 |
| p.A142T | LUAD | 1 |
| p.P230S | SKCM | 1 |
| p.P336S | SKCM | 1 |
| p.V201G | HNSC | 1 |
| p.F379S | LIHC | 1 |
| p.L87R | STAD | 1 |
| p.A2T | LUAD | 1 |
| p.S225F | HNSC | 1 |
| p.F182S | COAD | 1 |
| p.N132K | LUAD | 1 |
| p.D99N | SKCM | 1 |
| p.Q56K | HNSC | 1 |
| p.P374H | LUAD | 1 |
| p.M1I | COAD | 1 |
| p.I187T | LUAD | 1 |
| p.R249Q | STAD | 1 |
| p.E346Q | LIHC | 1 |
| p.D340Y | BLCA | 1 |
| p.R387H | DLBC | 1 |
| p.P75L | LUAD | 1 |
| p.E438K | COAD | 1 |
| p.R186H | STAD | 1 |
| p.P79L | SKCM | 1 |
| p.G133D | SKCM | 1 |
| p.V22L | LUAD | 1 |
| p.E346D | UCEC | 1 |
| p.E32D | BRCA | 1 |
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| TissGeneCNV for FMO2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FMO2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI452615 | FMO2-FMO2 | chr1:171176903 | chr1:171173038 |
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| TissGeneNet for FMO2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for FMO2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FMO2 |
| TissGeneDrug for FMO2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FMO2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023470 | Myeloid Leukemia | 3 | GAD |
| umls:C0011053 | Deafness | 1 | GAD |
| umls:C0014175 | Endometriosis | 1 | CTD_human |
| umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
| umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| umls:C0279565 | Invasive Lobular Breast Carcinoma | 1 | BeFree |
| umls:C0746883 | Febrile Neutropenia | 1 | BeFree |
| umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree |
| umls:C1384666 | hearing impairment | 1 | GAD |
| umls:C3887873 | Hearing Loss | 1 | GAD |
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