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| TissGeneSummary for TCERG1L |
 Gene summary |
| Basic gene information | Gene symbol | TCERG1L |
| Gene name | transcription elongation regulator 1-like | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 10q26.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_174937.3, | |
| Description | 5730476P14Riktranscription elongation regulator 1-like protein | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000176769 | ||
| HPRD : 18170 | ||
| Vega : OTTHUMG00000019276 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TCERG1L | |
| BioGPS: 256536 | ||
| Pathway | NCI Pathway Interaction Database: TCERG1L | |
| KEGG: TCERG1L | ||
| REACTOME: TCERG1L | ||
| Pathway Commons: TCERG1L | ||
| Context | iHOP: TCERG1L | |
| ligand binding site mutation search in PubMed: TCERG1L | ||
| UCL Cancer Institute: TCERG1L | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Thyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | THCA | |
| Reference showing the relevant tissue of TCERG1L | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TCERG1L |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -1.950827855 | -0.565147855 | -1.38568 | 7.71E-08 | 3.58E-07 |
| HNSC | -0.277628971 | 0.872336145 | -1.149965116 | 0.00361 | 0.010268647 |
| THCA | 8.181210721 | 6.973773433 | 1.207437288 | 0.000434 | 0.001077215 |
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| TissGene-miRNA for TCERG1L |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TCERG1L |
| TissGeneSNV for TCERG1L |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R376C | STAD | 2 |
| p.R574Q | HNSC | 1 |
| p.N380S | THCA | 1 |
| p.A245V | SKCM | 1 |
| p.E577D | UCEC | 1 |
| p.P122S | SKCM | 1 |
| p.P207H | UCEC | 1 |
| p.R303Q | OV | 1 |
| p.D309N | STAD | 1 |
| p.T175M | COAD | 1 |
| p.I222M | STAD | 1 |
| p.R267H | PAAD | 1 |
| p.P207H | ESCA | 1 |
| p.V366D | LUAD | 1 |
| p.F567L | LAML | 1 |
| p.A295T | LUAD | 1 |
| p.S307R | LUAD | 1 |
| p.S327N | UCEC | 1 |
| p.P386L | STAD | 1 |
| p.R547L | BLCA | 1 |
| p.W154L | LUAD | 1 |
| p.Q560H | LUAD | 1 |
| p.S467L | CESC | 1 |
| p.L569H | LUAD | 1 |
| p.V215M | SKCM | 1 |
| p.R390H | THYM | 1 |
| p.S234N | LUSC | 1 |
| p.H186N | SKCM | 1 |
| p.R390S | LUAD | 1 |
| p.A243T | KIRP | 1 |
| p.K539N | LGG | 1 |
| p.T350A | LGG | 1 |
| p.R552Q | UCEC | 1 |
| p.A171S | STAD | 1 |
| p.P205T | COAD | 1 |
| p.A244T | PAAD | 1 |
| p.E290K | LUSC | 1 |
| p.Q555* | BLCA | 1 |
| p.R293Q | STAD | 1 |
| p.K506Q | KIRP | 1 |
| p.E475D | UCEC | 1 |
| p.R409T | OV | 1 |
| p.P128S | SKCM | 1 |
| p.P149S | SKCM | 1 |
| p.N167_N168delinsX | COAD | 1 |
| p.K572N | LUSC | 1 |
| p.R293Q | LUSC | 1 |
| p.P207S | CESC | 1 |
| p.V348F | LUAD | 1 |
| p.R293P | CESC | 1 |
| p.R493Q | UCEC | 1 |
| p.D401N | SKCM | 1 |
| p.R303Q | UCEC | 1 |
| p.E528A | DLBC | 1 |
| p.T350M | STAD | 1 |
| p.V264M | CESC | 1 |
| p.C424F | LUAD | 1 |
| p.K584N | PAAD | 1 |
| p.P444L | COAD | 1 |
| p.E422D | PRAD | 1 |
| p.S153R | UCEC | 1 |
| p.P266T | LUAD | 1 |
| p.F457S | ESCA | 1 |
| p.G324V | CESC | 1 |
| p.V137I | COAD | 1 |
| p.A241T | PAAD | 1 |
| p.I275T | LUAD | 1 |
| p.R453H | PAAD | 1 |
| p.R390C | STAD | 1 |
| p.R550M | STAD | 1 |
| p.R420Q | UCEC | 1 |
| p.T131A | LUAD | 1 |
| p.E475K | UCEC | 1 |
| p.R267C | BRCA | 1 |
| p.S250F | SKCM | 1 |
| p.K312I | KIRC | 1 |
| p.P278L | SKCM | 1 |
| p.P387S | SARC | 1 |
| p.P122S | LUSC | 1 |
| p.E180K | BLCA | 1 |
| p.P128R | SKCM | 1 |
| p.P122Q | LUSC | 1 |
| p.A171P | LUAD | 1 |
| p.P143S | SKCM | 1 |
| p.E180V | LUAD | 1 |
| p.M371I | UCEC | 1 |
| p.R291W | COAD | 1 |
| p.R504I | UCEC | 1 |
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| TissGeneCNV for TCERG1L |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TCERG1L |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LGG | TCGA-S9-A7R3-01A | TCERG1L-CNTN1 | CDS-5'UTR | chr10:133106473 | chr12:41302158 |
| Chimerdb3.0 | FusionScan | UCEC | TCGA-FI-A3PV-01A | ROR2-TCERG1L | Out-of-Frame | chr9:94538022 | chr10:132902617 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-86-7713-01A | DDX58-TCERG1L | Out-of-Frame | chr9:32526058 | chr10:132902617 |
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| TissGeneNet for TCERG1L |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for TCERG1L |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TCERG1L |
| TissGeneDrug for TCERG1L |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TCERG1L |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| umls:C0010346 | Crohn Disease | 1 | GAD |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C1263846 | Attention deficit hyperactivity disorder | 1 | GAD |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
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