 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for WDR72 |
 Gene summary |
| Basic gene information | Gene symbol | WDR72 |
| Gene name | WD repeat domain 72 | |
| Synonyms | AI2A3 | |
| Cytomap | UCSC genome browser: 15q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001277176.1, NM_182758.3,NR_102334.1,NR_102335.1,NR_102336.1, | |
| Description | WD repeat-containing protein 72 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 613214 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166415 | ||
| HPRD : 10987 | ||
| Vega : OTTHUMG00000131939 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_WDR72 | |
| BioGPS: 256764 | ||
| Pathway | NCI Pathway Interaction Database: WDR72 | |
| KEGG: WDR72 | ||
| REACTOME: WDR72 | ||
| Pathway Commons: WDR72 | ||
| Context | iHOP: WDR72 | |
| ligand binding site mutation search in PubMed: WDR72 | ||
| UCL Cancer Institute: WDR72 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTHCA | |
| Reference showing the relevant tissue of WDR72 | ||
| Description by TissGene annotations | Protective TissGene in OS Risk TissGene in RFS Protective TissGene in RFS Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for WDR72 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | 1.397826029 | -2.622386471 | 4.0202125 | 2.62E-08 | 9.82E-07 |
| THCA | 2.428477248 | 4.999909451 | -2.571432203 | 1.04E-23 | 9.21E-22 |
| LUSC | 2.334547537 | -2.336552463 | 4.6711 | 1.12E-16 | 8.64E-16 |
| KIRP | 2.874116654 | 5.047094779 | -2.172978125 | 1.72E-06 | 8.33E-06 |
| KIRC | 2.84107221 | 5.13838471 | -2.2973125 | 5.70E-17 | 3.34E-16 |
| LIHC | 0.442565654 | 3.720161654 | -3.277596 | 1.73E-09 | 1.79E-08 |
| HNSC | 1.956911422 | 0.295497468 | 1.661413953 | 0.0046 | 0.012530266 |
| COAD | 0.205010885 | -2.058612192 | 2.263623077 | 0.00359 | 0.008928138 |
| ESCA | 2.945941654 | -1.0767038 | 4.022645455 | 0.000225 | 0.005647461 |
| BLCA | 2.69356797 | -1.061010977 | 3.754578947 | 0.000707 | 0.005294168 |
| PRAD | -4.18509873 | -2.8319045 | -1.353194231 | 0.00168 | 0.005033262 |
| Top |
| TissGene-miRNA for WDR72 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for WDR72 |
| TissGeneSNV for WDR72 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S928Y | UCEC | 2 |
| p.S829Y | UCEC | 2 |
| p.E748K | SKCM | 2 |
| p.R601Q | SKCM | 2 |
| p.E1035K | SKCM | 2 |
| p.R886K | SKCM | 2 |
| p.H680Y | SKCM | 2 |
| p.S775F | SKCM | 1 |
| p.T66S | BRCA | 1 |
| p.F839L | UCEC | 1 |
| p.Y952D | HNSC | 1 |
| p.K777E | LUAD | 1 |
| p.D536Y | LUAD | 1 |
| p.M329I | BLCA | 1 |
| p.F258V | ESCA | 1 |
| p.V997F | HNSC | 1 |
| p.W674* | SKCM | 1 |
| p.R219* | UCEC | 1 |
| p.A741T | LGG | 1 |
| p.D1071N | READ | 1 |
| p.V925I | ESCA | 1 |
| p.S652L | STAD | 1 |
| p.A373D | DLBC | 1 |
| p.A1094S | HNSC | 1 |
| p.P306L | COAD | 1 |
| p.E545K | LUAD | 1 |
| p.R151K | UCEC | 1 |
| p.L668S | PAAD | 1 |
| p.P355T | LUSC | 1 |
| p.D356E | ACC | 1 |
| p.S928Y | READ | 1 |
| p.F244L | SKCM | 1 |
| p.C1076* | THCA | 1 |
| p.M121I | LUAD | 1 |
| p.L921S | SKCM | 1 |
| p.K773T | BRCA | 1 |
| p.L647P | STAD | 1 |
| p.S191L | HNSC | 1 |
| p.E996K | STAD | 1 |
| p.R268G | ESCA | 1 |
| p.Q981E | COAD | 1 |
| p.K722M | SKCM | 1 |
| p.L144M | LUSC | 1 |
| p.L686V | KIRC | 1 |
| p.S976P | UCEC | 1 |
| p.S864F | SKCM | 1 |
| p.G364S | PRAD | 1 |
| p.C534Y | STAD | 1 |
| p.E206* | UCEC | 1 |
| p.T404S | HNSC | 1 |
| p.K717N | UCEC | 1 |
| p.G535V | LUAD | 1 |
| p.P358S | SKCM | 1 |
| p.E598X | READ | 1 |
| p.S167F | SKCM | 1 |
| p.D609N | SKCM | 1 |
| p.R298K | BLCA | 1 |
| p.W565* | UCEC | 1 |
| p.A995V | UCEC | 1 |
| p.V186L | READ | 1 |
| p.R896* | LGG | 1 |
| p.Q378X | SKCM | 1 |
| p.S833Y | READ | 1 |
| p.S19N | STAD | 1 |
| p.V667F | PRAD | 1 |
| p.S475L | GBM | 1 |
| p.E889* | LUSC | 1 |
| p.V568I | SKCM | 1 |
| p.V1069A | KIRP | 1 |
| p.K449N | THYM | 1 |
| p.F909V | LGG | 1 |
| p.G35E | SKCM | 1 |
| p.A995V | HNSC | 1 |
| p.S291N | LIHC | 1 |
| p.M1001I | SKCM | 1 |
| p.S152L | SKCM | 1 |
| p.I619F | LUSC | 1 |
| p.M772R | HNSC | 1 |
| p.G131V | DLBC | 1 |
| p.P1008L | SKCM | 1 |
| p.A716V | UCEC | 1 |
| p.W158* | SKCM | 1 |
| p.E520K | BLCA | 1 |
| p.C534* | UCEC | 1 |
| p.C221R | STAD | 1 |
| p.D899H | STAD | 1 |
| p.E569D | UCEC | 1 |
| p.T588A | STAD | 1 |
| p.S466L | SKCM | 1 |
| p.Q282E | CESC | 1 |
| p.F707L | UCEC | 1 |
| p.Q37H | STAD | 1 |
| p.H307L | SARC | 1 |
| p.I619N | BLCA | 1 |
| p.S64L | SKCM | 1 |
| p.V997I | PAAD | 1 |
| p.G852L | LUAD | 1 |
| p.D793N | SKCM | 1 |
| p.P567L | STAD | 1 |
| p.E1036X | COAD | 1 |
| p.I391F | UCEC | 1 |
| p.M562I | SKCM | 1 |
| p.T104I | COAD | 1 |
| p.L544F | SKCM | 1 |
| p.C1099* | SARC | 1 |
| p.E183D | LUSC | 1 |
| p.S871L | LUAD | 1 |
| p.R956Q | SKCM | 1 |
| p.R896Q | SKCM | 1 |
| p.K627Q | STAD | 1 |
| p.C421R | KICH | 1 |
| p.R601Q | BRCA | 1 |
| p.I854K | BRCA | 1 |
| p.S704F | SKCM | 1 |
| p.W11X | SKCM | 1 |
| p.H680L | BLCA | 1 |
| p.K142R | LUAD | 1 |
| p.G403E | SKCM | 1 |
| p.E897Q | LUAD | 1 |
| p.R728K | SKCM | 1 |
| p.L551Q | GBM | 1 |
| p.W805* | BLCA | 1 |
| p.G852V | LUAD | 1 |
| p.S1081F | PAAD | 1 |
| p.K785I | SARC | 1 |
| p.Q197R | COAD | 1 |
| p.N820S | BRCA | 1 |
| p.F707L | ESCA | 1 |
| p.D764N | SKCM | 1 |
| p.G852* | LUAD | 1 |
| p.M1024I | LUAD | 1 |
| p.Q378* | SKCM | 1 |
| p.D810Y | BLCA | 1 |
| p.D73N | SKCM | 1 |
| p.A509V | SKCM | 1 |
| p.R219Q | UCEC | 1 |
| p.P106L | SKCM | 1 |
| p.S635I | UCEC | 1 |
| p.F798C | COAD | 1 |
| p.S4Y | PRAD | 1 |
| p.Y279N | LUAD | 1 |
| p.S894Y | READ | 1 |
| p.Q37K | OV | 1 |
| p.S749T | ESCA | 1 |
| p.M326I | SKCM | 1 |
| p.I934K | LUAD | 1 |
| p.G125D | THYM | 1 |
| p.G806* | LUSC | 1 |
| p.D872G | PRAD | 1 |
| p.D478Y | CESC | 1 |
| p.S976F | HNSC | 1 |
| p.I602N | KIRC | 1 |
| p.R219Q | UCS | 1 |
| p.F505L | UCEC | 1 |
| p.E206X | COAD | 1 |
| p.P918S | UCEC | 1 |
| p.D1068E | LUSC | 1 |
| p.E520K | SKCM | 1 |
| p.V94G | SKCM | 1 |
| p.F665L | LUSC | 1 |
| p.R525M | PRAD | 1 |
| p.V491L | LUAD | 1 |
| p.E585K | SKCM | 1 |
| p.V677I | GBM | 1 |
| p.Q1040K | THYM | 1 |
| p.R601Q | COAD | 1 |
| p.S538F | SKCM | 1 |
| p.M1R | DLBC | 1 |
| p.S703P | LUAD | 1 |
| p.Y337* | SKCM | 1 |
| p.L834F | HNSC | 1 |
| p.S207F | SKCM | 1 |
| p.F74L | LUAD | 1 |
| p.D379Y | READ | 1 |
| p.G255W | LUAD | 1 |
| p.S4F | SKCM | 1 |
| p.W674X | SKCM | 1 |
| p.S475L | SKCM | 1 |
| p.H556P | LUSC | 1 |
| p.S851G | KIRC | 1 |
| p.S775C | LUAD | 1 |
| p.P1073S | LGG | 1 |
| p.L487M | STAD | 1 |
| p.A54V | BRCA | 1 |
| p.A265V | THYM | 1 |
| p.G510V | LUAD | 1 |
| p.S174Y | PRAD | 1 |
| p.S1003I | UCS | 1 |
| p.R554Q | PRAD | 1 |
| p.R896Q | BLCA | 1 |
| p.Q13E | LUSC | 1 |
| p.W11* | SKCM | 1 |
| p.H1090N | READ | 1 |
| p.R601* | LGG | 1 |
| p.L727M | LUSC | 1 |
| p.Q981* | SKCM | 1 |
| p.V1069M | HNSC | 1 |
| p.G12R | SKCM | 1 |
| p.R30* | BRCA | 1 |
| p.A145D | SARC | 1 |
| p.M1016I | LUAD | 1 |
| p.D382N | LUAD | 1 |
| p.L819F | COAD | 1 |
| p.Q779P | LUAD | 1 |
| p.D495N | SKCM | 1 |
| p.E889K | SKCM | 1 |
| p.S1102F | SKCM | 1 |
| Top |
| TissGeneCNV for WDR72 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for WDR72 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A1KY-01A | IL11RA-WDR72 | 5'UTR-CDS | chr9:34652230 | chr15:53889471 |
| Top |
| TissGeneNet for WDR72 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for WDR72 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for WDR72 |
| TissGeneDrug for WDR72 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for WDR72 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0002452 | Amelogenesis Imperfecta | 6 | BeFree |
| umls:C1561535 | Creatinine finding | 2 | GAD |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | GAD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C1561643 | Chronic Kidney Diseases | 1 | GWASCAT |
| umls:C1561955 | Fibrinogen Adverse Event | 1 | GAD |
| umls:C0399372 | Amelogenesis Imperfecta hypomaturation type | 0 | ORPHANET |
| umls:C2750771 | Amelogenesis Imperfecta, Hypomaturation Type, Iia3 | 0 | CLINVAR,CTD_human,MGD |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |