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| TissGeneSummary for ZNF683 |
 Gene summary |
| Basic gene information | Gene symbol | ZNF683 |
| Gene name | zinc finger protein 683 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 1p36.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001114759.1, NM_173574.2, | |
| Description | hypothetical protein MGC33414 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000176083 | ||
| HPRD : 14563 | ||
| Vega : OTTHUMG00000003521 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZNF683 | |
| BioGPS: 257101 | ||
| Pathway | NCI Pathway Interaction Database: ZNF683 | |
| KEGG: ZNF683 | ||
| REACTOME: ZNF683 | ||
| Pathway Commons: ZNF683 | ||
| Context | iHOP: ZNF683 | |
| ligand binding site mutation search in PubMed: ZNF683 | ||
| UCL Cancer Institute: ZNF683 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ZNF683 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZNF683 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | 0.459657834 | -1.396278166 | 1.855936 | 6.01E-06 | 1.99E-05 |
| KIRC | 1.295699889 | -1.544740388 | 2.840440278 | 1.32E-24 | 1.52E-23 |
| KIRP | 0.225625584 | -0.996736916 | 1.2223625 | 0.00579 | 0.013452 |
| LUSC | 0.952834775 | 2.277532814 | -1.324698039 | 5.66E-05 | 0.000120135 |
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| TissGene-miRNA for ZNF683 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZNF683 |
| TissGeneSNV for ZNF683 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D79N | SKCM | 2 |
| p.R249Q | STAD | 1 |
| p.H424D | SKCM | 1 |
| p.Q129H | UCEC | 1 |
| p.Q162H | UCEC | 1 |
| p.C324Y | PRAD | 1 |
| p.K121E | LGG | 1 |
| p.G264V | LUAD | 1 |
| p.G422R | SKCM | 1 |
| p.V240A | UCEC | 1 |
| p.A42G | LIHC | 1 |
| p.R348H | STAD | 1 |
| p.R297L | SKCM | 1 |
| p.H444D | SKCM | 1 |
| p.A72E | STAD | 1 |
| p.D51H | OV | 1 |
| p.D95N | UCEC | 1 |
| p.T94I | STAD | 1 |
| p.K121N | UCEC | 1 |
| p.R272Q | SKCM | 1 |
| p.S117F | SKCM | 1 |
| p.S263F | BLCA | 1 |
| p.R432W | SKCM | 1 |
| p.G54S | LUAD | 1 |
| p.P349S | SKCM | 1 |
| p.L199V | LUAD | 1 |
| p.G422E | STAD | 1 |
| p.R434S | LUAD | 1 |
| p.A145P | COAD | 1 |
| p.S180T | SARC | 1 |
| p.H425Y | SKCM | 1 |
| p.G434V | UCEC | 1 |
| p.R418C | BLCA | 1 |
| p.E484Q | HNSC | 1 |
| p.K367* | LUAD | 1 |
| p.P202T | UCS | 1 |
| p.E242K | SKCM | 1 |
| p.C76F | LUAD | 1 |
| p.Q351K | STAD | 1 |
| p.G402E | STAD | 1 |
| p.A149S | UCEC | 1 |
| p.S24F | SARC | 1 |
| p.D48G | CESC | 1 |
| p.G402R | SKCM | 1 |
| p.P203S | UCEC | 1 |
| p.W391* | BLCA | 1 |
| p.G387R | HNSC | 1 |
| p.S24N | UCEC | 1 |
| p.M238L | KIRC | 1 |
| p.D477Y | LUAD | 1 |
| p.P299L | SKCM | 1 |
| p.A115T | UCEC | 1 |
| p.G54D | PAAD | 1 |
| p.K329T | UCEC | 1 |
| p.R272* | GBM | 1 |
| p.T304A | HNSC | 1 |
| p.P461L | SKCM | 1 |
| p.L188I | UCEC | 1 |
| p.R418G | LUAD | 1 |
| p.S71Y | BRCA | 1 |
| p.A248T | LGG | 1 |
| p.P441S | UCEC | 1 |
| p.D30N | SKCM | 1 |
| p.L220F | SKCM | 1 |
| p.P441L | SKCM | 1 |
| p.G264S | GBM | 1 |
| p.G144R | SKCM | 1 |
| p.H445Y | SKCM | 1 |
| p.A248T | COAD | 1 |
| p.A171V | SKCM | 1 |
| p.P91L | SKCM | 1 |
| p.Q439K | BRCA | 1 |
| p.D119N | COAD | 1 |
| p.C175R | CHOL | 1 |
| p.G93S | SKCM | 1 |
| p.W471C | LUAD | 1 |
| p.L211I | SKCM | 1 |
| p.R434H | PRAD | 1 |
| p.R376Q | PRAD | 1 |
| p.A396V | LUAD | 1 |
| p.L243V | LIHC | 1 |
| p.E3K | SKCM | 1 |
| p.L254F | SKCM | 1 |
| p.R376W | COAD | 1 |
| p.P203H | UCEC | 1 |
| p.S269F | SKCM | 1 |
| p.F150L | BLCA | 1 |
| p.P169L | SKCM | 1 |
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| TissGeneCNV for ZNF683 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZNF683 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ZNF683 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ZNF683 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZNF683 |
| TissGeneDrug for ZNF683 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZNF683 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0263454 | Chloracne | 1 | CTD_human |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C1561955 | Fibrinogen Adverse Event | 1 | GAD |
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