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| TissGeneSummary for SULT4A1 |
 Gene summary |
| Basic gene information | Gene symbol | SULT4A1 |
| Gene name | sulfotransferase family 4A, member 1 | |
| Synonyms | BR-STL-1|BRSTL1|DJ388M5.3|NST|SULTX3|hBR-STL-1 | |
| Cytomap | UCSC genome browser: 22q13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014351.3, NM_176874.1, | |
| Description | ST4A1brain sulfotransferase-like proteinhBR-STLnervous system cytosolic sulfotransferasenervous system sulfotransferasesulfotransferase 4A1sulfotransferase-related protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608359 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000130540 | ||
| HPRD : 07462 | ||
| Vega : OTTHUMG00000141314 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SULT4A1 | |
| BioGPS: 25830 | ||
| Pathway | NCI Pathway Interaction Database: SULT4A1 | |
| KEGG: SULT4A1 | ||
| REACTOME: SULT4A1 | ||
| Pathway Commons: SULT4A1 | ||
| Context | iHOP: SULT4A1 | |
| ligand binding site mutation search in PubMed: SULT4A1 | ||
| UCL Cancer Institute: SULT4A1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of SULT4A1 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SULT4A1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 0.444236471 | -2.327851029 | 2.7720875 | 1.31E-07 | 7.73E-07 |
| LUAD | -1.282982279 | -3.047040899 | 1.764058621 | 1.89E-06 | 6.06E-06 |
| COAD | -2.138436125 | 0.381221568 | -2.519657692 | 9.10E-06 | 4.22E-05 |
| LUSC | -0.380097965 | -3.093105808 | 2.713007843 | 5.40E-10 | 1.90E-09 |
| THCA | -2.024099228 | -3.691494143 | 1.667394915 | 2.84E-09 | 1.54E-08 |
| LIHC | -1.759106279 | -2.830224279 | 1.071118 | 0.0242 | 0.04597793 |
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| TissGene-miRNA for SULT4A1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-125b-5p | MIMAT0000423 | 0.018 | -0.31 | 60 |
| LUAD | hsa-miR-125a-5p | MIMAT0000443 | 0.0022 | -0.39 | 60 |
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| TissGeneMut for SULT4A1 |
| TissGeneSNV for SULT4A1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E160* | UCEC | 2 |
| p.H185Q | CHOL | 1 |
| p.M152I | SKCM | 1 |
| p.D281N | LUAD | 1 |
| p.P9S | LGG | 1 |
| p.S141F | SKCM | 1 |
| p.P118L | SKCM | 1 |
| p.D168N | SKCM | 1 |
| p.Q144* | SKCM | 1 |
| p.T58I | LIHC | 1 |
| p.D83E | LUAD | 1 |
| p.L60M | LUAD | 1 |
| p.R150W | STAD | 1 |
| p.M273I | LUAD | 1 |
| p.G78C | COAD | 1 |
| p.D277G | UCEC | 1 |
| p.D281N | SKCM | 1 |
| p.G173S | COAD | 1 |
| p.M152L | PRAD | 1 |
| p.R133C | SKCM | 1 |
| p.T227M | CESC | 1 |
| p.M80R | KIRC | 1 |
| p.D83N | STAD | 1 |
| p.R155* | HNSC | 1 |
| p.D137Y | LUAD | 1 |
| p.D137N | SKCM | 1 |
| p.P42T | COAD | 1 |
| p.T157I | SKCM | 1 |
| p.E63K | SKCM | 1 |
| p.R254Q | SKCM | 1 |
| p.Q144L | LUAD | 1 |
| p.G171S | SKCM | 1 |
| p.V88I | SARC | 1 |
| p.H111Y | SKCM | 1 |
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| TissGeneCNV for SULT4A1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SULT4A1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SULT4A1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| COAD (tumor) | COAD (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| KICH (tumor) | KICH (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| STAD (tumor) | STAD (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| THCA (tumor) | THCA (normal) |
| SULT4A1, POT1 (tumor) | SULT4A1, POT1 (normal) |
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| TissGeneProg for SULT4A1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SULT4A1 |
| TissGeneDrug for SULT4A1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SULT4A1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0036341 | Schizophrenia | 5 | BeFree,GAD |
| umls:C0025202 | melanoma | 2 | BeFree |
| umls:C0004936 | Mental disorders | 1 | BeFree |
| umls:C0007133 | Carcinoma, Papillary | 1 | BeFree |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0020429 | Hyperalgesia | 1 | BeFree |
| umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
| umls:C0030193 | Pain | 1 | BeFree |
| umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| umls:C0032000 | Pituitary Adenoma | 1 | BeFree |
| umls:C0036337 | Schizoaffective Disorder | 1 | BeFree |
| umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
| umls:C0221355 | Macrocephaly | 1 | BeFree |
| umls:C0338656 | Impaired cognition | 1 | BeFree |
| umls:C0338831 | Manic | 1 | BeFree |
| umls:C0406810 | Carney Complex | 1 | BeFree |
| umls:C0751214 | Hyperalgesia, Thermal | 1 | BeFree |
| umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree |
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