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| TissGeneSummary for GRP |
 Gene summary |
| Basic gene information | Gene symbol | GRP |
| Gene name | gastrin-releasing peptide | |
| Synonyms | BN|GRP-10|preproGRP|proGRP | |
| Cytomap | UCSC genome browser: 18q21.1-q21.32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001012512.1, NM_001012513.1,NM_002091.3, | |
| Description | bombesinneuromedin Cpre-progastrin releasing peptideprepro-GRP | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 137260 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000134443 | ||
| HPRD : 08845 | ||
| Vega : OTTHUMG00000132760 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GRP | |
| BioGPS: 2922 | ||
| Pathway | NCI Pathway Interaction Database: GRP | |
| KEGG: GRP | ||
| REACTOME: GRP | ||
| Pathway Commons: GRP | ||
| Context | iHOP: GRP | |
| ligand binding site mutation search in PubMed: GRP | ||
| UCL Cancer Institute: GRP | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCSTAD | |
| Reference showing the relevant tissue of GRP | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0007218 | neuropeptide signaling pathway | 8756537 | GO:0007218 | neuropeptide signaling pathway | 8756537 |
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| TissGeneExp for GRP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | -0.202285146 | -2.4557991 | 2.253513953 | 1.91E-07 | 1.75E-06 |
| BLCA | -1.45014451 | -3.007270826 | 1.557126316 | 0.00917 | 0.042049649 |
| COAD | 0.416058324 | -1.487680137 | 1.903738462 | 0.00217 | 0.005776999 |
| LUAD | -0.092630535 | 1.183600499 | -1.276231034 | 0.00233 | 0.004816765 |
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| TissGene-miRNA for GRP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GRP |
| TissGeneSNV for GRP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R4S | COAD | 11 |
| p.R4S | READ | 2 |
| p.R4S | STAD | 2 |
| p.G105D | STAD | 1 |
| p.Q137E | BLCA | 1 |
| p.G126D | STAD | 1 |
| p.R4S | PCPG | 1 |
| p.S125C | HNSC | 1 |
| p.L49V | ESCA | 1 |
| p.L87F | STAD | 1 |
| p.D112N | SKCM | 1 |
| p.T55A | BRCA | 1 |
| p.K53R | LIHC | 1 |
| p.R4S | THCA | 1 |
| p.G140R | SKCM | 1 |
| p.E92V | SKCM | 1 |
| p.L87P | SARC | 1 |
| p.L84F | SARC | 1 |
| p.V14F | ACC | 1 |
| p.L104M | STAD | 1 |
| p.E73Q | BLCA | 1 |
| p.M37L | CESC | 1 |
| p.E89* | BLCA | 1 |
| p.E92Q | BLCA | 1 |
| p.N146K | LUAD | 1 |
| p.S113* | LUSC | 1 |
| p.E63K | HNSC | 1 |
| p.P101L | SKCM | 1 |
| p.E73X | COAD | 1 |
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| TissGeneCNV for GRP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GRP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for GRP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| GRP, MEP1B, MEP1A, DPP4, GRPR (tumor) | GRP, MEP1B, MEP1A, DPP4, GRPR (normal) |
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| TissGeneProg for GRP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GRP |
| TissGeneDrug for GRP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GRP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0149925 | Small cell carcinoma of lung | 40 | BeFree,LHGDN |
| umls:C0600139 | Prostate carcinoma | 24 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 23 | BeFree |
| umls:C0027819 | Neuroblastoma | 11 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 10 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 9 | BeFree |
| umls:C0700095 | Central neuroblastoma | 9 | BeFree |
| umls:C0684249 | Carcinoma of lung | 8 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 7 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 7 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 7 | BeFree |
| umls:C0678222 | Breast Carcinoma | 6 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 5 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 5 | BeFree |
| umls:C0699790 | Colon Carcinoma | 5 | BeFree |
| umls:C0178874 | Tumor Progression | 4 | BeFree |
| umls:C1654637 | androgen independent prostate cancer | 4 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 3 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C0024121 | Lung Neoplasms | 3 | BeFree,LHGDN |
| umls:C0024623 | Malignant neoplasm of stomach | 3 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 3 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 3 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 3 | BeFree |
| umls:C1527249 | Colorectal Cancer | 3 | BeFree |
| umls:C1841972 | Glucocorticoid Receptor Deficiency | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree |
| umls:C0004096 | Asthma | 2 | BeFree |
| umls:C0007095 | Carcinoid Tumor | 2 | BeFree |
| umls:C0017150 | Gastrinoma | 2 | BeFree |
| umls:C0017636 | Glioblastoma | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 2 | BeFree,LHGDN |
| umls:C0206754 | Neuroendocrine Tumors | 2 | BeFree |
| umls:C0262584 | Carcinoma, Small Cell | 2 | BeFree |
| umls:C1378703 | Renal carcinoma | 2 | BeFree |
| umls:C1519670 | Tumor Angiogenesis | 2 | BeFree |
| umls:C0001818 | Agoraphobia | 1 | BeFree |
| umls:C0002622 | Amnesia | 1 | CTD_human |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0004936 | Mental disorders | 1 | BeFree |
| umls:C0005940 | Bone Diseases | 1 | BeFree |
| umls:C0006118 | Brain Neoplasms | 1 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0007133 | Carcinoma, Papillary | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree,LHGDN |
| umls:C0009375 | Colonic Neoplasms | 1 | LHGDN |
| umls:C0012546 | Diphtheria | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
| umls:C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
| umls:C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| umls:C0027765 | nervous system disorder | 1 | BeFree |
| umls:C0030319 | Panic Disorder | 1 | BeFree,GAD |
| umls:C0032019 | Pituitary Neoplasms | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0036690 | Septicemia | 1 | BeFree |
| umls:C0086438 | Hypogammaglobulinemia | 1 | BeFree |
| umls:C0151908 | Dry skin | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
| umls:C0162820 | Dermatitis, Allergic Contact | 1 | BeFree |
| umls:C0205698 | Undifferentiated carcinoma | 1 | BeFree |
| umls:C0206685 | Acinar Cell Carcinoma | 1 | BeFree |
| umls:C0221026 | X-linked agammaglobulinemia | 1 | BeFree |
| umls:C0238462 | Medullary carcinoma of thyroid | 1 | BeFree |
| umls:C0242966 | Systemic Inflammatory Response Syndrome | 1 | BeFree |
| umls:C0243026 | Sepsis | 1 | BeFree |
| umls:C0278701 | Gastric Adenocarcinoma | 1 | BeFree |
| umls:C0278727 | Small cell lung cancer recurrent | 1 | BeFree |
| umls:C0278804 | Adenocarcinoma of duodenum | 1 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0280089 | Carcinoid tumor of lung | 1 | BeFree |
| umls:C0338106 | Adenocarcinoma of colon | 1 | BeFree |
| umls:C0338656 | Impaired cognition | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0555198 | Malignant Glioma | 1 | BeFree |
| umls:C0684337 | Ewings sarcoma-primitive neuroectodermal tumor (PNET) | 1 | BeFree |
| umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 1 | BeFree |
| umls:C0850666 | Helicobacter pylori infection | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C0936223 | Metastatic Prostate Carcinoma | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
| umls:C1739363 | Prostatic Hypertrophy | 1 | BeFree |
| umls:C1868649 | PANIC DISORDER 1 | 1 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
| umls:C2937421 | Prostatic Hyperplasia | 1 | BeFree |
| umls:C2938905 | Central Nervous System Sensitization | 1 | BeFree |
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