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| TissGeneSummary for HABP2 |
 Gene summary |
| Basic gene information | Gene symbol | HABP2 |
| Gene name | hyaluronan binding protein 2 | |
| Synonyms | FSAP|HABP|HGFAL|PHBP | |
| Cytomap | UCSC genome browser: 10q25.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001177660.1, NM_004132.3, | |
| Description | factor VII activating proteinfactor VII-activating proteasefactor seven-activating proteasehepatocyte growth factor activator-like proteinhyaluronan-binding protein 2hyaluronic acid binding protein 2plasma hyaluronan binding proteinplasma hyalurona | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603924 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000148702 | ||
| HPRD : 04890 | ||
| Vega : OTTHUMG00000019073 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HABP2 | |
| BioGPS: 3026 | ||
| Pathway | NCI Pathway Interaction Database: HABP2 | |
| KEGG: HABP2 | ||
| REACTOME: HABP2 | ||
| Pathway Commons: HABP2 | ||
| Context | iHOP: HABP2 | |
| ligand binding site mutation search in PubMed: HABP2 | ||
| UCL Cancer Institute: HABP2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of HABP2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HABP2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -1.137141288 | 1.165521457 | -2.302662745 | 2.21E-07 | 5.98E-07 |
| LIHC | 7.294884281 | 9.415940281 | -2.121056 | 4.48E-07 | 2.63E-06 |
| KICH | -1.809899719 | 2.018396281 | -3.828296 | 2.44E-07 | 1.03E-06 |
| LUAD | 2.056175109 | 0.898840626 | 1.157334483 | 0.0112 | 0.019811987 |
| COAD | -2.435146642 | -4.419596642 | 1.98445 | 0.00148 | 0.00408398 |
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| TissGene-miRNA for HABP2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HABP2 |
| TissGeneSNV for HABP2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G81E | SKCM | 2 |
| p.P442S | SKCM | 2 |
| p.P132S | SKCM | 2 |
| p.P416S | SKCM | 2 |
| p.E557K | SKCM | 1 |
| p.C451S | SKCM | 1 |
| p.S84L | SKCM | 1 |
| p.E282A | SKCM | 1 |
| p.S450F | BLCA | 1 |
| p.P288T | GBM | 1 |
| p.P284S | KIRC | 1 |
| p.M232I | LUAD | 1 |
| p.P126S | SKCM | 1 |
| p.P39S | SKCM | 1 |
| p.Q212* | OV | 1 |
| p.G173E | SKCM | 1 |
| p.G519R | LUAD | 1 |
| p.G60R | COAD | 1 |
| p.P65S | SKCM | 1 |
| p.P106S | SKCM | 1 |
| p.E47D | UCEC | 1 |
| p.S490R | LUAD | 1 |
| p.P79S | SKCM | 1 |
| p.E188K | SKCM | 1 |
| p.S428F | LUSC | 1 |
| p.K169N | UCEC | 1 |
| p.G197D | STAD | 1 |
| p.P65T | LUAD | 1 |
| p.G559V | SARC | 1 |
| p.K371Q | READ | 1 |
| p.Q181H | LUAD | 1 |
| p.M206I | UCEC | 1 |
| p.T541I | SKCM | 1 |
| p.R155K | LIHC | 1 |
| p.E305G | STAD | 1 |
| p.T38I | UCEC | 1 |
| p.A214V | STAD | 1 |
| p.G159E | SKCM | 1 |
| p.G317D | HNSC | 1 |
| p.G158E | SKCM | 1 |
| p.E282V | SKCM | 1 |
| p.P291S | UCEC | 1 |
| p.H386Y | SKCM | 1 |
| p.G75E | SKCM | 1 |
| p.E264K | SKCM | 1 |
| p.C176G | OV | 1 |
| p.R208K | SKCM | 1 |
| p.R182K | SKCM | 1 |
| p.G94E | SKCM | 1 |
| p.F186L | UCS | 1 |
| p.Q279E | PCPG | 1 |
| p.C477S | SKCM | 1 |
| p.E290K | SKCM | 1 |
| p.C165S | BLCA | 1 |
| p.K107N | SKCM | 1 |
| p.Q481P | PAAD | 1 |
| p.E253K | UCEC | 1 |
| p.K418Q | STAD | 1 |
| p.D280V | STAD | 1 |
| p.E446K | BLCA | 1 |
| p.T515I | SKCM | 1 |
| p.E308A | SKCM | 1 |
| p.R462H | LUSC | 1 |
| p.G239E | HNSC | 1 |
| p.N50T | STAD | 1 |
| p.K254Q | STAD | 1 |
| p.K381N | UCEC | 1 |
| p.P76S | SKCM | 1 |
| p.G184E | SKCM | 1 |
| p.G460R | SKCM | 1 |
| p.A552T | SKCM | 1 |
| p.C108S | SKCM | 1 |
| p.P158S | SKCM | 1 |
| p.Q388R | LIHC | 1 |
| p.R122W | HNSC | 1 |
| p.S334L | CESC | 1 |
| p.S277L | BRCA | 1 |
| p.R155S | LIHC | 1 |
| p.P152S | SKCM | 1 |
| p.G81E | UCS | 1 |
| p.C88* | LUAD | 1 |
| p.P35Q | KIRC | 1 |
| p.S171L | SKCM | 1 |
| p.P81L | SKCM | 1 |
| p.E308V | SKCM | 1 |
| p.P102S | SKCM | 1 |
| p.S399G | UCEC | 1 |
| p.V184I | READ | 1 |
| p.L100I | COAD | 1 |
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| TissGeneCNV for HABP2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HABP2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for HABP2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| COAD (tumor) | COAD (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| KICH (tumor) | KICH (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| STAD (tumor) | STAD (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| THCA (tumor) | THCA (normal) |
| HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor) | HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal) |
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| TissGeneProg for HABP2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HABP2 |
| TissGeneDrug for HABP2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB08818 | Hyaluronic acid | Binder | Small molecule | Approved|Vet_approved |
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| TissGeneDisease for HABP2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007282 | Carotid Stenosis | 3 | BeFree |
| umls:C0149871 | Deep Vein Thrombosis | 3 | BeFree |
| umls:C1861172 | Venous Thromboembolism | 3 | GAD,LHGDN |
| umls:C0003850 | Arteriosclerosis | 2 | BeFree |
| umls:C0004153 | Atherosclerosis | 2 | BeFree,LHGDN |
| umls:C0035222 | Respiratory Distress Syndrome, Adult | 2 | BeFree,LHGDN |
| umls:C0040038 | Thromboembolism | 2 | BeFree |
| umls:C0239946 | Fibrosis, Liver | 2 | BeFree |
| umls:C0000786 | Spontaneous abortion | 1 | CTD_human |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | GAD |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0019087 | Hemorrhagic Disorders | 1 | GAD |
| umls:C0019196 | Hepatitis C | 1 | BeFree,GAD |
| umls:C0023890 | Liver Cirrhosis | 1 | BeFree,GAD |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0042487 | Venous Thrombosis | 1 | GAD |
| umls:C0333186 | Restenosis | 1 | BeFree |
| umls:C0340708 | Deep vein thrombosis of lower limb | 1 | BeFree |
| umls:C0341439 | Chronic liver disease | 1 | BeFree |
| umls:C0398623 | Thrombophilia | 1 | BeFree,CTD_human |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0584960 | Factor V Leiden mutation | 1 | BeFree |
| umls:C0745744 | End Stage Liver Disease | 1 | BeFree |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C1623038 | Cirrhosis | 1 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
| umls:C3501844 | Familial Nonmedullary Thyroid Cancer | 1 | BeFree |
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