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| TissGeneSummary for LCE1C |
 Gene summary |
| Basic gene information | Gene symbol | LCE1C |
| Gene name | late cornified envelope 1C | |
| Synonyms | LEP3 | |
| Cytomap | UCSC genome browser: 1q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001276331.1, NM_178351.3, | |
| Description | late cornified envelope protein 1Clate envelope protein 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612605 | |
| HGNC : HGNC | ||
| HPRD : 13967 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LCE1C | |
| BioGPS: 353133 | ||
| Pathway | NCI Pathway Interaction Database: LCE1C | |
| KEGG: LCE1C | ||
| REACTOME: LCE1C | ||
| Pathway Commons: LCE1C | ||
| Context | iHOP: LCE1C | |
| ligand binding site mutation search in PubMed: LCE1C | ||
| UCL Cancer Institute: LCE1C | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of LCE1C | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for LCE1C |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 0.627789445 | -1.439230163 | 2.067019608 | 2.02E-09 | 6.74E-09 |
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| TissGene-miRNA for LCE1C |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LCE1C |
| TissGeneSNV for LCE1C |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T17I | CESC | 3 |
| p.S6N | CESC | 2 |
| p.N15I | THCA | 1 |
| p.G111S | PRAD | 1 |
| p.C22Y | SKCM | 1 |
| p.C10* | LUAD | 1 |
| p.C33F | LUAD | 1 |
| p.R83H | STAD | 1 |
| p.S41F | BRCA | 1 |
| p.R83H | CESC | 1 |
| p.C16Y | COAD | 1 |
| p.G108A | PRAD | 1 |
| p.P30L | SKCM | 1 |
| p.C52Y | SKCM | 1 |
| p.S74N | SKCM | 1 |
| p.G115E | SKCM | 1 |
| p.G66R | SKCM | 1 |
| p.R81M | UCEC | 1 |
| p.Q91H | COAD | 1 |
| p.Q91* | BLCA | 1 |
| p.K23M | BRCA | 1 |
| p.P25S | STAD | 1 |
| p.P18H | LUAD | 1 |
| p.H79Q | LUSC | 1 |
| p.G49R | OV | 1 |
| p.R82H | HNSC | 1 |
| p.R83C | PAAD | 1 |
| p.G19E | SKCM | 1 |
| p.G65V | LUAD | 1 |
| p.G65V | HNSC | 1 |
| p.G65W | LUAD | 1 |
| p.R84T | PRAD | 1 |
| p.G66E | LUSC | 1 |
| p.K15M | THCA | 1 |
| p.S104N | SKCM | 1 |
| p.P25S | PAAD | 1 |
| p.K28R | STAD | 1 |
| p.S100L | STAD | 1 |
| p.G49E | SKCM | 1 |
| p.R83C | LUAD | 1 |
| p.S41Y | LUAD | 1 |
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| TissGeneCNV for LCE1C |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LCE1C |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for LCE1C |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for LCE1C |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LCE1C |
| TissGeneDrug for LCE1C |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LCE1C |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0003872 | Arthritis, Psoriatic | 1 | GAD |
| umls:C0020538 | Hypertensive disease | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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