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| TissGeneSummary for RGSL1 |
 Gene summary |
| Basic gene information | Gene symbol | RGSL1 |
| Gene name | regulator of G-protein signaling like 1 | |
| Synonyms | RGSL|RGSL2 | |
| Cytomap | UCSC genome browser: 1q25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032267.2, NM_181572.2,NM_001137669.1, | |
| Description | regulator of G-protein signaling like 2regulator of G-protein signaling protein-like | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611012 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000121446 | ||
| HPRD : 17971 | ||
| Vega : OTTHUMG00000035217 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RGSL1 | |
| BioGPS: 353299 | ||
| Pathway | NCI Pathway Interaction Database: RGSL1 | |
| KEGG: RGSL1 | ||
| REACTOME: RGSL1 | ||
| Pathway Commons: RGSL1 | ||
| Context | iHOP: RGSL1 | |
| ligand binding site mutation search in PubMed: RGSL1 | ||
| UCL Cancer Institute: RGSL1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of RGSL1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for RGSL1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for RGSL1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for RGSL1 |
| TissGeneSNV for RGSL1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V222I | BRCA | 2 |
| p.P940H | BRCA | 1 |
| p.F884L | READ | 1 |
| p.A378V | ESCA | 1 |
| p.L342P | LIHC | 1 |
| p.M725L | ACC | 1 |
| p.V895I | LIHC | 1 |
| p.A59T | UCEC | 1 |
| p.C239G | COAD | 1 |
| p.E396D | UCEC | 1 |
| p.D118N | LIHC | 1 |
| p.D488Y | ESCA | 1 |
| p.F513L | COAD | 1 |
| p.Y127F | BRCA | 1 |
| p.Q1042H | UCEC | 1 |
| p.D405N | ESCA | 1 |
| p.V960I | BRCA | 1 |
| p.L487I | UCEC | 1 |
| p.A274S | ESCA | 1 |
| p.I361F | LIHC | 1 |
| p.R304I | UCEC | 1 |
| p.E518D | COAD | 1 |
| p.S129P | ESCA | 1 |
| p.T735M | ACC | 1 |
| p.A853T | KICH | 1 |
| p.L295M | LUAD | 1 |
| p.P74T | COAD | 1 |
| p.F701L | UCEC | 1 |
| p.L635R | UCEC | 1 |
| p.E490* | UCEC | 1 |
| p.E173G | LIHC | 1 |
| p.E541* | LIHC | 1 |
| p.F702I | THYM | 1 |
| p.D273Y | LIHC | 1 |
| p.S300* | ACC | 1 |
| p.R666W | SARC | 1 |
| p.E541X | LIHC | 1 |
| p.L388P | UCEC | 1 |
| p.H209Y | UCEC | 1 |
| p.I683V | SARC | 1 |
| p.Q1051* | CESC | 1 |
| p.V569E | SARC | 1 |
| p.L521I | UCEC | 1 |
| p.E709X | COAD | 1 |
| p.R623C | COAD | 1 |
| p.V349A | UCEC | 1 |
| p.E721* | UCEC | 1 |
| p.R637M | UCEC | 1 |
| p.E613D | COAD | 1 |
| p.V895F | COAD | 1 |
| p.R978S | KIRP | 1 |
| p.W748G | LIHC | 1 |
| p.E564A | LIHC | 1 |
| p.E909K | ESCA | 1 |
| p.V971A | UCEC | 1 |
| p.E1075Q | ACC | 1 |
| p.I683V | ACC | 1 |
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| TissGeneCNV for RGSL1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for RGSL1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for RGSL1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| COAD (tumor) | COAD (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| KICH (tumor) | KICH (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| STAD (tumor) | STAD (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| THCA (tumor) | THCA (normal) |
| RGSL1, DCUN1D1 (tumor) | RGSL1, DCUN1D1 (normal) |
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| TissGeneProg for RGSL1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for RGSL1 |
| TissGeneDrug for RGSL1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for RGSL1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
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