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| TissGeneSummary for ITIH2 |
 Gene summary |
| Basic gene information | Gene symbol | ITIH2 |
| Gene name | inter-alpha-trypsin inhibitor heavy chain 2 | |
| Synonyms | H2P|SHAP | |
| Cytomap | UCSC genome browser: 10p15 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002216.2, | |
| Description | ITI heavy chain H2ITI-HC2inter-alpha (globulin) inhibitor H2inter-alpha (globulin) inhibitor, H2 polypeptideinter-alpha-inhibitor heavy chain 2inter-alpha-trypsin inhibitor complex component IIinter-alpha-trypsin inhibitor heavy chain H2serum-deriv | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 146640 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000151655 | ||
| HPRD : 00890 | ||
| Vega : OTTHUMG00000017633 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ITIH2 | |
| BioGPS: 3698 | ||
| Pathway | NCI Pathway Interaction Database: ITIH2 | |
| KEGG: ITIH2 | ||
| REACTOME: ITIH2 | ||
| Pathway Commons: ITIH2 | ||
| Context | iHOP: ITIH2 | |
| ligand binding site mutation search in PubMed: ITIH2 | ||
| UCL Cancer Institute: ITIH2 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of ITIH2 | ||
| Description by TissGene annotations | Cancer gene TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ITIH2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -2.023825547 | 0.900884257 | -2.924709804 | 1.24E-15 | 8.41E-15 |
| BRCA | -2.0508579 | 1.259271925 | -3.310129825 | 8.56E-21 | 6.54E-20 |
| LUAD | -0.757915371 | 1.068253595 | -1.826168966 | 9.54E-08 | 3.74E-07 |
| KIRC | -2.031853733 | 0.624276823 | -2.656130556 | 3.84E-18 | 2.55E-17 |
| KICH | -3.248993233 | 1.047790767 | -4.296784 | 8.10E-14 | 1.19E-12 |
| STAD | -1.105409983 | -2.358794358 | 1.253384375 | 0.00987 | 0.034132289 |
| KIRP | -1.628647483 | 0.099599392 | -1.728246875 | 0.000112 | 0.000376468 |
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| TissGene-miRNA for ITIH2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ITIH2 |
| TissGeneSNV for ITIH2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E272K | SKCM | 2 |
| p.L842V | LUAD | 2 |
| p.R356Q | SKCM | 2 |
| p.E428K | UCEC | 2 |
| p.L828V | BLCA | 1 |
| p.L625M | LUAD | 1 |
| p.G406* | SKCM | 1 |
| p.M63I | LIHC | 1 |
| p.R356X | SKCM | 1 |
| p.E266K | PRAD | 1 |
| p.A86V | SKCM | 1 |
| p.E689* | UCEC | 1 |
| p.Q369H | UCEC | 1 |
| p.S130I | SARC | 1 |
| p.E283A | UCEC | 1 |
| p.R189M | GBM | 1 |
| p.S616Y | LUAD | 1 |
| p.P22T | THYM | 1 |
| p.A530T | READ | 1 |
| p.L172I | LUAD | 1 |
| p.M85V | LUAD | 1 |
| p.D721H | BLCA | 1 |
| p.M326I | SKCM | 1 |
| p.R394Q | STAD | 1 |
| p.Q69H | STAD | 1 |
| p.D270Y | LUAD | 1 |
| p.P880H | STAD | 1 |
| p.G858R | SKCM | 1 |
| p.K573N | LUAD | 1 |
| p.S79P | LIHC | 1 |
| p.F12L | PRAD | 1 |
| p.F346L | UCEC | 1 |
| p.V544A | BRCA | 1 |
| p.L340R | COAD | 1 |
| p.D636N | HNSC | 1 |
| p.V108D | PRAD | 1 |
| p.G138C | LUAD | 1 |
| p.T167M | PRAD | 1 |
| p.T514A | STAD | 1 |
| p.L13R | LUAD | 1 |
| p.G113E | SKCM | 1 |
| p.A604T | UCEC | 1 |
| p.A365T | SKCM | 1 |
| p.Y758N | LUAD | 1 |
| p.E428K | SKCM | 1 |
| p.D460N | BLCA | 1 |
| p.A599T | PAAD | 1 |
| p.S570* | LUAD | 1 |
| p.K714N | UCEC | 1 |
| p.V837I | UCEC | 1 |
| p.Q78K | COAD | 1 |
| p.F165L | SARC | 1 |
| p.E468A | COAD | 1 |
| p.R356X | ACC | 1 |
| p.G478E | SKCM | 1 |
| p.K749N | PAAD | 1 |
| p.D421H | HNSC | 1 |
| p.G684E | SKCM | 1 |
| p.W358* | SKCM | 1 |
| p.V105M | KIRC | 1 |
| p.I21N | SKCM | 1 |
| p.I678V | PRAD | 1 |
| p.R905K | COAD | 1 |
| p.S412T | SKCM | 1 |
| p.W669R | LUAD | 1 |
| p.D534Y | LUAD | 1 |
| p.K439N | LUAD | 1 |
| p.Q353H | UCS | 1 |
| p.S886I | PAAD | 1 |
| p.D567E | LUAD | 1 |
| p.Q69* | SKCM | 1 |
| p.K924Q | UCEC | 1 |
| p.A86T | UCEC | 1 |
| p.E61K | SKCM | 1 |
| p.D124E | LUAD | 1 |
| p.R499W | READ | 1 |
| p.G753R | SKCM | 1 |
| p.S570L | SKCM | 1 |
| p.E557D | UCEC | 1 |
| p.P22L | SKCM | 1 |
| p.S570L | HNSC | 1 |
| p.R356* | SKCM | 1 |
| p.G220E | SARC | 1 |
| p.Q614R | UCEC | 1 |
| p.L827F | KIRC | 1 |
| p.M333I | BLCA | 1 |
| p.Q53* | UCEC | 1 |
| p.Q102R | LIHC | 1 |
| p.S549L | READ | 1 |
| p.E272K | BLCA | 1 |
| p.F449Y | STAD | 1 |
| p.W358L | ESCA | 1 |
| p.Y142* | LUAD | 1 |
| p.T777S | BLCA | 1 |
| p.P22S | SKCM | 1 |
| p.S74I | UCEC | 1 |
| p.P667L | PRAD | 1 |
| p.E778K | BLCA | 1 |
| p.H248L | LUSC | 1 |
| p.F291S | BLCA | 1 |
| p.N801S | SKCM | 1 |
| p.Y586C | COAD | 1 |
| p.V438I | STAD | 1 |
| p.P238L | SKCM | 1 |
| p.I216M | LUSC | 1 |
| p.G911E | SKCM | 1 |
| p.V544I | STAD | 1 |
| p.D564N | UCEC | 1 |
| p.R265W | LUAD | 1 |
| p.I388M | CESC | 1 |
| p.K582E | DLBC | 1 |
| p.A114V | LUAD | 1 |
| p.E210Q | KIRC | 1 |
| p.R259K | SKCM | 1 |
| p.G125V | LUAD | 1 |
| p.M326I | BLCA | 1 |
| p.D161H | CESC | 1 |
| p.R905K | CESC | 1 |
| p.R581K | SKCM | 1 |
| p.L288M | ACC | 1 |
| p.T552M | UCEC | 1 |
| p.R204W | UCEC | 1 |
| p.A560S | STAD | 1 |
| p.R356* | ACC | 1 |
| p.E217K | SKCM | 1 |
| p.R204W | HNSC | 1 |
| p.D840N | SKCM | 1 |
| p.V419A | COAD | 1 |
| p.G427C | STAD | 1 |
| p.N96K | OV | 1 |
| p.A268V | LUAD | 1 |
| p.S320F | SKCM | 1 |
| p.P40S | SKCM | 1 |
| p.S823P | LGG | 1 |
| p.H208Y | LUAD | 1 |
| p.M63I | LUAD | 1 |
| p.D702N | BLCA | 1 |
| p.E633K | SKCM | 1 |
| p.R359I | COAD | 1 |
| p.R356* | UCEC | 1 |
| p.P854S | LIHC | 1 |
| p.Q802H | ESCA | 1 |
| p.Q201H | HNSC | 1 |
| p.Y183C | STAD | 1 |
| p.R189K | SKCM | 1 |
| p.V255I | SKCM | 1 |
| p.S732C | LUAD | 1 |
| p.G125A | LUAD | 1 |
| p.R606I | READ | 1 |
| p.A268V | COAD | 1 |
| p.G843E | SKCM | 1 |
| p.E134D | BLCA | 1 |
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| TissGeneCNV for ITIH2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ITIH2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ITIH2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
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| KICH (tumor) | KICH (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (tumor) | ITIH2, PITX3, ATP5C1, FCER1A, SPINT2 (normal) |
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| TissGeneProg for ITIH2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ITIH2 |
| TissGeneDrug for ITIH2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ITIH2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | LHGDN |
| umls:C0022876 | Premature Obstetric Labor | 1 | LHGDN |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | LHGDN |
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