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| TissGeneSummary for C11orf87 |
 Gene summary |
| Basic gene information | Gene symbol | C11orf87 |
| Gene name | chromosome 11 open reading frame 87 | |
| Synonyms | LOH11CR1A|NEURIM1 | |
| Cytomap | UCSC genome browser: 11q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_207645.3, | |
| Description | neuronal integral membrane protein 1uncharacterized protein C11orf87 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000185742 | ||
| HPRD : 14218 | ||
| Vega : OTTHUMG00000166559 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C11orf87 | |
| BioGPS: 399947 | ||
| Pathway | NCI Pathway Interaction Database: C11orf87 | |
| KEGG: C11orf87 | ||
| REACTOME: C11orf87 | ||
| Pathway Commons: C11orf87 | ||
| Context | iHOP: C11orf87 | |
| ligand binding site mutation search in PubMed: C11orf87 | ||
| UCL Cancer Institute: C11orf87 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of C11orf87 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C11orf87 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | -2.064335297 | -0.776560297 | -1.287775 | 3.77E-07 | 2.96E-06 |
| BRCA | -1.876224737 | -0.383725614 | -1.492499123 | 2.72E-20 | 1.97E-19 |
| LUSC | 0.149424696 | -1.158006677 | 1.307431373 | 0.0016 | 0.002884868 |
| HNSC | 0.160428344 | -1.563620494 | 1.724048837 | 9.04E-05 | 0.000410909 |
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| TissGene-miRNA for C11orf87 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C11orf87 |
| TissGeneSNV for C11orf87 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P165L | SKCM | 1 |
| p.L196Q | LIHC | 1 |
| p.G34V | THCA | 1 |
| p.N32K | LUAD | 1 |
| p.A178T | COAD | 1 |
| p.A178E | HNSC | 1 |
| p.G39C | HNSC | 1 |
| p.T45S | LUAD | 1 |
| p.P168L | LUAD | 1 |
| p.G119D | COAD | 1 |
| p.Q49K | LUSC | 1 |
| p.E128* | LUAD | 1 |
| p.P157L | THCA | 1 |
| p.A178T | STAD | 1 |
| p.P157R | OV | 1 |
| p.E100K | SKCM | 1 |
| p.A178T | UCEC | 1 |
| p.V68A | LUAD | 1 |
| p.P168Q | LIHC | 1 |
| p.G37S | COAD | 1 |
| p.P135S | SKCM | 1 |
| p.R103W | COAD | 1 |
| p.A5V | UCEC | 1 |
| p.S30I | LUAD | 1 |
| p.C162W | HNSC | 1 |
| p.R136W | HNSC | 1 |
| p.A122V | LUAD | 1 |
| p.R36H | BRCA | 1 |
| p.T124N | LUAD | 1 |
| p.S172I | BRCA | 1 |
| p.T61M | THCA | 1 |
| p.G108S | STAD | 1 |
| p.E132K | SKCM | 1 |
| p.A97V | READ | 1 |
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| TissGeneCNV for C11orf87 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C11orf87 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for C11orf87 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for C11orf87 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C11orf87 |
| TissGeneDrug for C11orf87 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C11orf87 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1271104 | Blood pressure finding | 1 | GAD |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
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