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| TissGeneSummary for LPA |
 Gene summary |
| Basic gene information | Gene symbol | LPA |
| Gene name | lipoprotein, Lp(a) | |
| Synonyms | AK38|APOA|LP | |
| Cytomap | UCSC genome browser: 6q26 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005577.2, | |
| Description | antiangiogenic AK38 proteinapo(a)apolipoprotein(a)lp(a) | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 152200 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000198670 | ||
| HPRD : 01063 | ||
| Vega : OTTHUMG00000015956 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LPA | |
| BioGPS: 4018 | ||
| Pathway | NCI Pathway Interaction Database: LPA | |
| KEGG: LPA | ||
| REACTOME: LPA | ||
| Pathway Commons: LPA | ||
| Context | iHOP: LPA | |
| ligand binding site mutation search in PubMed: LPA | ||
| UCL Cancer Institute: LPA | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of LPA | ||
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for LPA |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.449060456 | -0.878364456 | -1.570696 | 3.25E-05 | 9.34E-05 |
| KIRC | -1.941640011 | -0.6734414 | -1.268198611 | 3.32E-07 | 8.80E-07 |
| LIHC | 4.644403544 | 9.058109544 | -4.413706 | 1.67E-17 | 8.24E-16 |
| LUAD | -2.081929283 | -0.710472387 | -1.371456897 | 9.11E-12 | 6.39E-11 |
| KIRP | -2.102206331 | 0.236856169 | -2.3390625 | 7.87E-08 | 4.85E-07 |
| Top |
| TissGene-miRNA for LPA |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LPA |
| TissGeneSNV for LPA |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R1397* | SKCM | 3 |
| p.E65K | SKCM | 3 |
| p.E1135K | SKCM | 3 |
| p.E1653K | SKCM | 2 |
| p.R1331C | SKCM | 2 |
| p.P1373S | SKCM | 2 |
| p.A1430V | STAD | 2 |
| p.Q1834H | STAD | 2 |
| p.C1688* | ESCA | 1 |
| p.V911I | COAD | 1 |
| p.P1028T | LUAD | 1 |
| p.R1390Q | SKCM | 1 |
| p.T1739M | OV | 1 |
| p.P68L | STAD | 1 |
| p.G1398D | ACC | 1 |
| p.P1853S | SKCM | 1 |
| p.W1831* | SKCM | 1 |
| p.E1344G | BRCA | 1 |
| p.P1487S | SKCM | 1 |
| p.A868V | LUAD | 1 |
| p.R37X | SKCM | 1 |
| p.G943R | SKCM | 1 |
| p.S1682I | HNSC | 1 |
| p.R1570S | LUAD | 1 |
| p.A1670V | HNSC | 1 |
| p.R1397Q | GBM | 1 |
| p.P1703L | SKCM | 1 |
| p.P1590L | LUAD | 1 |
| p.T1349A | LUSC | 1 |
| p.T1349M | OV | 1 |
| p.E1266K | SKCM | 1 |
| p.M1117I | SKCM | 1 |
| p.T837S | LUAD | 1 |
| p.R1421W | ESCA | 1 |
| p.C1720R | UCEC | 1 |
| p.A1491_splice | LUSC | 1 |
| p.G958* | UCEC | 1 |
| p.T1591I | LUAD | 1 |
| p.G1173E | SKCM | 1 |
| p.E1966K | SKCM | 1 |
| p.G1393E | SKCM | 1 |
| p.Q1622H | UCEC | 1 |
| p.G1621V | LUAD | 1 |
| p.W1123C | LUAD | 1 |
| p.P880H | LGG | 1 |
| p.P1560L | SKCM | 1 |
| p.T1433S | LUAD | 1 |
| p.R820S | OV | 1 |
| p.A1254E | THYM | 1 |
| p.T1754M | UCEC | 1 |
| p.P1146Q | PRAD | 1 |
| p.A977E | UCEC | 1 |
| p.G1727R | SKCM | 1 |
| p.D1774N | HNSC | 1 |
| p.H1978D | BLCA | 1 |
| p.M1231I | LUSC | 1 |
| p.R1840M | ESCA | 1 |
| p.S1154F | SKCM | 1 |
| p.Q21K | COAD | 1 |
| p.P884A | LUSC | 1 |
| p.F1845L | COAD | 1 |
| p.A868V | COAD | 1 |
| p.Q1622H | LUAD | 1 |
| p.H1879Q | LUAD | 1 |
| p.V1364M | THYM | 1 |
| p.P1757T | LUAD | 1 |
| p.Y1687F | HNSC | 1 |
| p.N1321S | SKCM | 1 |
| p.M967V | LUAD | 1 |
| p.I916V | UCEC | 1 |
| p.P884T | LUAD | 1 |
| p.P1049S | SKCM | 1 |
| p.D1795G | LIHC | 1 |
| p.Q1386* | SKCM | 1 |
| p.C1228F | SKCM | 1 |
| p.E1599K | LUSC | 1 |
| p.R1464* | LGG | 1 |
| p.C1924F | BRCA | 1 |
| p.E1151K | SKCM | 1 |
| p.D1566N | SKCM | 1 |
| p.T1068I | SKCM | 1 |
| p.Y1312F | LUAD | 1 |
| p.E1599D | UCEC | 1 |
| p.W1343X | SKCM | 1 |
| p.G1186* | LUAD | 1 |
| p.R1422K | SKCM | 1 |
| p.Y1322* | LUSC | 1 |
| p.T1522P | SKCM | 1 |
| p.P1567L | READ | 1 |
| p.M1195I | HNSC | 1 |
| p.A1976V | PAAD | 1 |
| p.V1070L | LUAD | 1 |
| p.S1191F | BLCA | 1 |
| p.P1246T | LUAD | 1 |
| p.E1583* | UCEC | 1 |
| p.P1362L | SKCM | 1 |
| p.N1219I | LUAD | 1 |
| p.E1091D | PAAD | 1 |
| p.Q933* | SARC | 1 |
| p.A1096V | STAD | 1 |
| p.V911I | KIRP | 1 |
| p.V1499F | LUSC | 1 |
| p.T1949I | SKCM | 1 |
| p.P918L | UCEC | 1 |
| p.E907K | SKCM | 1 |
| p.R37* | HNSC | 1 |
| p.D1805N | SKCM | 1 |
| p.C1323Y | BLCA | 1 |
| p.P1487L | SKCM | 1 |
| p.E932G | LUSC | 1 |
| p.Q1307R | STAD | 1 |
| p.A18T | SKCM | 1 |
| p.S1886F | COAD | 1 |
| p.G943R | CESC | 1 |
| p.E1344A | SKCM | 1 |
| p.T1116N | LIHC | 1 |
| p.Q1810H | SKCM | 1 |
| p.T1349M | STAD | 1 |
| p.E1548X | TGCT | 1 |
| p.W1343* | SKCM | 1 |
| p.E1311K | SKCM | 1 |
| p.H30R | STAD | 1 |
| p.D27N | SKCM | 1 |
| p.P1531L | BLCA | 1 |
| p.C1688X | ESCA | 1 |
| p.R1511X | SKCM | 1 |
| p.G1050E | SKCM | 1 |
| p.P1226S | SKCM | 1 |
| p.R876K | SKCM | 1 |
| p.L2004F | STAD | 1 |
| p.D1566A | LUAD | 1 |
| p.G2006R | LUSC | 1 |
| p.P410S | BRCA | 1 |
| p.E923K | LIHC | 1 |
| p.R1464Q | BLCA | 1 |
| p.D1172N | ESCA | 1 |
| p.E1964D | SKCM | 1 |
| p.A1486S | LUAD | 1 |
| p.R1445C | SKCM | 1 |
| p.P1119T | LUAD | 1 |
| p.T1182P | SKCM | 1 |
| p.R1464X | UCS | 1 |
| p.T1185P | LUAD | 1 |
| p.A1980V | ESCA | 1 |
| p.R1751K | SKCM | 1 |
| p.D1795G | UCEC | 1 |
| p.A1934D | ESCA | 1 |
| p.T45K | KIRC | 1 |
| p.L1798I | THYM | 1 |
| p.G1072E | SKCM | 1 |
| p.G1727E | SKCM | 1 |
| p.P1269L | SKCM | 1 |
| p.D1392N | SKCM | 1 |
| p.P1497L | PRAD | 1 |
| p.V1701A | UCEC | 1 |
| p.C1323S | PCPG | 1 |
| p.P1492T | LUAD | 1 |
| p.R37* | SKCM | 1 |
| p.G831* | KIRC | 1 |
| p.S1866F | SKCM | 1 |
| p.H30Q | CESC | 1 |
| p.G1406E | SARC | 1 |
| p.P1590L | SKCM | 1 |
| p.G1557W | LUAD | 1 |
| p.P1049L | SKCM | 1 |
| p.S852C | PAAD | 1 |
| p.P1538Q | LUAD | 1 |
| p.R1177X | COAD | 1 |
| p.V911I | STAD | 1 |
| p.R1508Q | SKCM | 1 |
| p.W1855* | LUAD | 1 |
| p.A2024D | LUAD | 1 |
| p.N987S | LIHC | 1 |
| p.Q1190* | BRCA | 1 |
| p.E1091K | SKCM | 1 |
| p.Q848K | LUAD | 1 |
| p.H1978Y | STAD | 1 |
| p.K2001I | COAD | 1 |
| p.A924D | SARC | 1 |
| p.A1733V | HNSC | 1 |
| p.L1253I | OV | 1 |
| p.R37Q | BRCA | 1 |
| p.P1112H | UCEC | 1 |
| p.F1791S | SKCM | 1 |
| p.R1692Q | CESC | 1 |
| p.G1619S | SKCM | 1 |
| p.C1551F | HNSC | 1 |
| p.T1159M | COAD | 1 |
| p.Q848K | STAD | 1 |
| p.E1047K | SKCM | 1 |
| p.P19H | KIRP | 1 |
| p.P878S | SKCM | 1 |
| p.R1100S | LGG | 1 |
| p.T1319S | LUAD | 1 |
| p.R1016L | BLCA | 1 |
| p.G1050W | LUSC | 1 |
| p.P1148S | SKCM | 1 |
| p.Y1503C | LUAD | 1 |
| p.E1977D | LUAD | 1 |
| p.R1647P | SKCM | 1 |
| p.T1484S | SKCM | 1 |
| p.D1452N | SKCM | 1 |
| p.M872I | SKCM | 1 |
| p.T1265M | LGG | 1 |
| p.E1583K | SKCM | 1 |
| p.R1397X | SKCM | 1 |
| p.P1005H | LUAD | 1 |
| p.C1574R | HNSC | 1 |
| p.A924S | LUAD | 1 |
| p.G2035E | HNSC | 1 |
| p.L1690P | KIRC | 1 |
| p.P1542T | LUSC | 1 |
| p.A977E | BRCA | 1 |
| p.G1279R | SKCM | 1 |
| p.G1626D | SKCM | 1 |
| p.G1991A | BLCA | 1 |
| p.R1342K | SKCM | 1 |
| p.T1474P | LUAD | 1 |
| p.E1041K | SKCM | 1 |
| p.S1602C | BLCA | 1 |
| p.R860W | SKCM | 1 |
| p.H1534R | LUAD | 1 |
| p.R1614Q | OV | 1 |
| p.E1548K | SKCM | 1 |
| p.R2025L | HNSC | 1 |
| p.R1614W | GBM | 1 |
| p.R1729W | READ | 1 |
| p.D1167N | SKCM | 1 |
| p.R1570K | COAD | 1 |
| p.C1579Y | LUSC | 1 |
| p.S1623R | HNSC | 1 |
| p.P1226H | PAAD | 1 |
| p.W1123R | BLCA | 1 |
| p.R1464* | UCS | 1 |
| p.S53L | BLCA | 1 |
| p.G2006E | SKCM | 1 |
| p.Q1490H | ESCA | 1 |
| p.Q1622L | LUAD | 1 |
| p.T1243P | SKCM | 1 |
| p.R1625Q | SKCM | 1 |
| p.I1777T | UCEC | 1 |
| p.Q1718* | SKCM | 1 |
| p.V1252A | UCEC | 1 |
| p.Q26P | LUAD | 1 |
| p.Y885H | LUAD | 1 |
| p.C1551F | LUAD | 1 |
| p.G46* | LUSC | 1 |
| p.T1182I | PAAD | 1 |
| p.V1030F | LUAD | 1 |
| p.R1422S | LUSC | 1 |
| p.V1856L | BRCA | 1 |
| p.V995A | LUAD | 1 |
| p.R1464L | HNSC | 1 |
| p.R1625X | COAD | 1 |
| p.K2001I | UCEC | 1 |
| p.W1831X | SKCM | 1 |
| p.G1634R | SKCM | 1 |
| p.R1438M | ESCA | 1 |
| p.P1208T | UCEC | 1 |
| p.P1269S | SKCM | 1 |
| p.P1428L | SKCM | 1 |
| p.G945* | UCEC | 1 |
| p.P1233L | SKCM | 1 |
| p.A883S | LUAD | 1 |
| p.C1616X | STAD | 1 |
| p.A912V | OV | 1 |
| p.T888M | PRAD | 1 |
| p.P1094S | COAD | 1 |
| p.G1406E | SKCM | 1 |
| p.E1375K | SKCM | 1 |
| p.M1117L | LUAD | 1 |
| p.Y1655N | SKCM | 1 |
| p.T1349M | BRCA | 1 |
| p.D1719E | READ | 1 |
| p.T331M | OV | 1 |
| p.D1167Y | LGG | 1 |
| p.E1697* | PRAD | 1 |
| p.A51T | KIRP | 1 |
| p.R1283X | COAD | 1 |
| p.T1672K | LUSC | 1 |
| p.P1590S | THYM | 1 |
| p.S1597I | ESCA | 1 |
| p.Q1559K | COAD | 1 |
| p.C1616* | STAD | 1 |
| p.R1614L | STAD | 1 |
| p.R1438S | TGCT | 1 |
| p.G1520E | SKCM | 1 |
| p.G1210D | STAD | 1 |
| p.Y941H | KIRP | 1 |
| p.R1293K | SKCM | 1 |
| p.R974W | DLBC | 1 |
| p.D1501N | SKCM | 1 |
| p.C1168R | STAD | 1 |
| p.S1528P | BLCA | 1 |
| p.R1511* | SKCM | 1 |
| p.P1368S | SKCM | 1 |
| p.V1051I | SKCM | 1 |
| p.T1349M | ESCA | 1 |
| p.V1026L | BRCA | 1 |
| Top |
| TissGeneCNV for LPA |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LPA |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for LPA |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| COAD (tumor) | COAD (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| KICH (tumor) | KICH (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| STAD (tumor) | STAD (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (tumor) | LPA, SETDB1, FN1, IGSF21, ELANE, CANX, FBLN5, LRP2, FGB, APOH, CELA1, MMP12 (normal) |
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| Top |
| TissGeneProg for LPA |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for LPA |
| TissGeneDrug for LPA |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00513 | Aminocaproic Acid | Other | Small molecule | Approved|Investigational |
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| TissGeneDisease for LPA |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010068 | Coronary heart disease | 52 | BeFree,CTD_human,GAD,GWASCAT,LHGDN |
| umls:C1956346 | Coronary Artery Disease | 39 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0010054 | Coronary Arteriosclerosis | 34 | BeFree |
| umls:C0004153 | Atherosclerosis | 31 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0003850 | Arteriosclerosis | 29 | BeFree,LHGDN |
| umls:C0027051 | Myocardial Infarction | 21 | BeFree,GAD |
| umls:C0007222 | Cardiovascular Diseases | 18 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0038454 | Cerebrovascular accident | 14 | BeFree,CTD_human,GAD,LHGDN |
| umls:C2239176 | Liver carcinoma | 9 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 7 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 7 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 7 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 6 | BeFree |
| umls:C0678222 | Breast Carcinoma | 6 | BeFree |
| umls:C0699790 | Colon Carcinoma | 6 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 5 | BeFree,GAD |
| umls:C0085096 | Peripheral Vascular Diseases | 5 | BeFree,GAD,LHGDN |
| umls:C0011849 | Diabetes Mellitus | 4 | BeFree,LHGDN |
| umls:C0020445 | Hypercholesterolemia, Familial | 4 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 4 | BeFree |
| umls:C0023903 | Liver neoplasms | 4 | BeFree |
| umls:C0042373 | Vascular Diseases | 4 | BeFree |
| umls:C0333186 | Restenosis | 4 | BeFree,GAD |
| umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree |
| umls:C0020443 | Hypercholesterolemia | 3 | BeFree,CTD_human |
| umls:C0020538 | Hypertensive disease | 3 | BeFree,LHGDN |
| umls:C0085580 | Essential Hypertension | 3 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 3 | BeFree,GAD |
| umls:C0242339 | Dyslipidemias | 3 | BeFree,GAD |
| umls:C0948008 | Ischemic stroke | 3 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 3 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 2 | BeFree,GAD |
| umls:C0003507 | Aortic Valve Stenosis | 2 | BeFree |
| umls:C0007273 | Carotid Artery Diseases | 2 | BeFree,GAD |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0011269 | Dementia, Vascular | 2 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree |
| umls:C0011884 | Diabetic Retinopathy | 2 | BeFree |
| umls:C0019693 | HIV Infections | 2 | BeFree |
| umls:C0020476 | Hyperlipoproteinemias | 2 | BeFree |
| umls:C0022658 | Kidney Diseases | 2 | BeFree |
| umls:C0027726 | Nephrotic Syndrome | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree,GAD |
| umls:C0029463 | Osteosarcoma | 2 | BeFree |
| umls:C0035309 | Retinal Diseases | 2 | BeFree |
| umls:C0040038 | Thromboembolism | 2 | BeFree,CTD_human |
| umls:C0155626 | Acute myocardial infarction | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0342880 | Polygenic hypercholesterolemia | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 2 | BeFree |
| umls:C0919267 | ovarian neoplasm | 2 | BeFree |
| umls:C1704436 | Peripheral Arterial Diseases | 2 | BeFree |
| umls:C2316810 | Chronic kidney disease stage 5 | 2 | BeFree |
| umls:C3542024 | AORTIC VALVE DISEASE 2 | 2 | BeFree |
| umls:C0002726 | Amyloidosis | 1 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | GAD |
| umls:C0002875 | Cooley's anemia | 1 | BeFree |
| umls:C0004096 | Asthma | 1 | GAD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0005779 | Blood Coagulation Disorders | 1 | BeFree |
| umls:C0007282 | Carotid Stenosis | 1 | LHGDN |
| umls:C0007766 | Intracranial Aneurysm | 1 | BeFree,GAD |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0008495 | Chorioamnionitis | 1 | GAD |
| umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 1 | LHGDN |
| umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | BeFree |
| umls:C0015944 | Fetal Membranes, Premature Rupture | 1 | GAD |
| umls:C0020517 | Hypersensitivity | 1 | GAD |
| umls:C0020623 | Hypolipoproteinemias | 1 | CTD_human |
| umls:C0021775 | Intermittent Claudication | 1 | BeFree |
| umls:C0022876 | Premature Obstetric Labor | 1 | GAD |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
| umls:C0023440 | Acute Erythroblastic Leukemia | 1 | BeFree |
| umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0032285 | Pneumonia | 1 | BeFree |
| umls:C0032914 | Pre-Eclampsia | 1 | GAD |
| umls:C0034065 | Pulmonary Embolism | 1 | BeFree |
| umls:C0035078 | Kidney Failure | 1 | BeFree |
| umls:C0035344 | Retinopathy of Prematurity | 1 | BeFree |
| umls:C0040053 | Thrombosis | 1 | LHGDN |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042487 | Venous Thrombosis | 1 | CTD_human |
| umls:C0043459 | Zellweger Syndrome | 1 | BeFree |
| umls:C0078911 | AIDS-Associated Nephropathy | 1 | BeFree |
| umls:C0085413 | Polycystic Kidney, Autosomal Dominant | 1 | BeFree |
| umls:C0151526 | Premature Birth | 1 | GAD |
| umls:C0151544 | Gastrointestinal carcinoma | 1 | BeFree |
| umls:C0151650 | Renal fibrosis | 1 | BeFree |
| umls:C0162291 | Retinal ischemia | 1 | BeFree |
| umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | BeFree |
| umls:C0220656 | Malignant ascites | 1 | BeFree |
| umls:C0333184 | Calcific stenosis | 1 | BeFree |
| umls:C0342883 | Cholesteryl Ester Transfer Protein Deficiency | 1 | BeFree |
| umls:C0346429 | Multiple malignancy | 1 | BeFree |
| umls:C0428791 | Aortic valve calcification | 1 | GWASCAT |
| umls:C0494463 | Alzheimer Disease, Late Onset | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | GAD |
| umls:C0577631 | Carotid Atherosclerosis | 1 | BeFree |
| umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0751956 | Acute Cerebrovascular Accidents | 1 | BeFree |
| umls:C0878486 | Arteriolosclerosis | 1 | LHGDN |
| umls:C0948089 | Acute Coronary Syndrome | 1 | BeFree |
| umls:C1512981 | Mammary Tumorigenesis | 1 | BeFree |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
| umls:C1800706 | Idiopathic Pulmonary Fibrosis | 1 | BeFree |
| umls:C1861172 | Venous Thromboembolism | 1 | GAD |
| umls:C2584620 | Thrombophilia, hereditary | 1 | BeFree |
| umls:C2919032 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 1 | GAD |
| umls:C1835362 | Lp(A) Deficiency, Congenital | 0 | CLINVAR |
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