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| TissGeneSummary for MSI1 |
 Gene summary |
| Basic gene information | Gene symbol | MSI1 |
| Gene name | musashi RNA-binding protein 1 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 12q24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002442.3, | |
| Description | RNA-binding protein Musashi homolog 1musashi-1musashi1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603328 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000135097 | ||
| HPRD : 04509 | ||
| Vega : OTTHUMG00000169344 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MSI1 | |
| BioGPS: 4440 | ||
| Pathway | NCI Pathway Interaction Database: MSI1 | |
| KEGG: MSI1 | ||
| REACTOME: MSI1 | ||
| Pathway Commons: MSI1 | ||
| Context | iHOP: MSI1 | |
| ligand binding site mutation search in PubMed: MSI1 | ||
| UCL Cancer Institute: MSI1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
| Reference showing the relevant tissue of MSI1 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MSI1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | 3.655150783 | 2.634535398 | 1.020615385 | 3.79E-09 | 5.18E-08 |
| LUSC | 1.626793731 | -1.218702347 | 2.845496078 | 1.10E-10 | 4.14E-10 |
| BLCA | 0.667534082 | -1.588508023 | 2.256042105 | 0.00508 | 0.026709031 |
| HNSC | 0.144246444 | -1.061716346 | 1.205962791 | 0.00602 | 0.015860656 |
| LIHC | 0.069858398 | -1.279773602 | 1.349632 | 0.00342 | 0.008193981 |
| LUAD | 0.032863846 | -0.999741326 | 1.032605172 | 0.0014 | 0.002993518 |
| KIRP | -1.610089602 | 0.079204148 | -1.68929375 | 0.000106 | 0.000358991 |
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| TissGene-miRNA for MSI1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-138-5p | MIMAT0000430 | 0.038 | -0.28 | 56 |
| ACC | hsa-miR-490-3p | MIMAT0002806 | 0.01 | -0.29 | 78 |
| ACC | hsa-miR-490-3p | MIMAT0002806 | 0.01 | -0.29 | 78 |
| LUAD | hsa-miR-125a-5p | MIMAT0000443 | 0.0066 | -0.35 | 60 |
| UCS | hsa-miR-137 | MIMAT0000429 | 0.021 | -0.36 | 56 |
| UCS | hsa-miR-181d-5p | MIMAT0002821 | 0.0057 | -0.37 | 56 |
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| TissGeneMut for MSI1 |
| TissGeneSNV for MSI1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G234V | LGG | 2 |
| p.G153W | LIHC | 1 |
| p.Y361S | PAAD | 1 |
| p.T292M | HNSC | 1 |
| p.M207I | SKCM | 1 |
| p.G73R | KIRC | 1 |
| p.P254Q | SKCM | 1 |
| p.Y361H | STAD | 1 |
| p.K187N | COAD | 1 |
| p.V163M | ESCA | 1 |
| p.P244H | THYM | 1 |
| p.F68V | ESCA | 1 |
| p.I169N | KIRP | 1 |
| p.P254Q | HNSC | 1 |
| p.D91N | LUSC | 1 |
| p.K183N | THCA | 1 |
| p.V66F | THCA | 1 |
| p.R98Q | THCA | 1 |
| p.R107* | UCEC | 1 |
| p.P313L | SKCM | 1 |
| p.P254S | SKCM | 1 |
| p.K110M | SKCM | 1 |
| p.P192S | BRCA | 1 |
| p.V66A | UCEC | 1 |
| p.N175S | STAD | 1 |
| p.S229R | BRCA | 1 |
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| TissGeneCNV for MSI1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MSI1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CV-7253-01A | PXN-MSI1 | CDS-3UTR | Chr12:120659426 | Chr12:120780908 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-55-7570-01A | PXN-MSI1 | Out-of-frame | Chr12:120703420 | Chr12:120802558 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-34-5232-01A | C12orf34-MSI1 | 5UTR-CDS | Chr12:110152702 | Chr12:120802558 |
| Top |
| TissGeneNet for MSI1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| COAD (tumor) | COAD (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| KICH (tumor) | KICH (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| STAD (tumor) | STAD (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| THCA (tumor) | THCA (normal) |
| MSI1, PNMA1 (tumor) | MSI1, PNMA1 (normal) |
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| TissGeneProg for MSI1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MSI1 |
| TissGeneDrug for MSI1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MSI1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0596263 | Carcinogenesis | 9 | BeFree |
| umls:C0017638 | Glioma | 5 | BeFree |
| umls:C0025149 | Medulloblastoma | 4 | BeFree,LHGDN |
| umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
| umls:C0017636 | Glioblastoma | 3 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
| umls:C0699790 | Colon Carcinoma | 3 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0027766 | Nervous System Neoplasms | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
| umls:C0302592 | Cervix carcinoma | 2 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | LHGDN |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0006118 | Brain Neoplasms | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007786 | Brain Ischemia | 1 | RGD |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0014170 | Endometrial Neoplasms | 1 | LHGDN |
| umls:C0014175 | Endometriosis | 1 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree,LHGDN |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | BeFree |
| umls:C0041327 | Tuberculosis, Pulmonary | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
| umls:C0236642 | Pick Disease of the Brain | 1 | LHGDN |
| umls:C0278803 | Adenocarcinoma of small intestine | 1 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0338106 | Adenocarcinoma of colon | 1 | BeFree |
| umls:C0349458 | Cervical intraepithelial neoplasia grade 1 | 1 | BeFree |
| umls:C0349459 | Cervical intraepithelial neoplasia grade 2 | 1 | BeFree |
| umls:C0555198 | Malignant Glioma | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0751955 | Brain Infarction | 1 | RGD |
| umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C2987191 | Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type | 1 | BeFree |
| umls:C3539878 | Triple Negative Breast Neoplasms | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
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