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| TissGeneSummary for KPRP |
 Gene summary |
| Basic gene information | Gene symbol | KPRP |
| Gene name | keratinocyte proline-rich protein | |
| Synonyms | C1orf45 | |
| Cytomap | UCSC genome browser: 1q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001025231.1, | |
| Description | hKPRPkeratinocyte expressed, proline-rich protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 613260 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000203786 | ||
| Vega : OTTHUMG00000012402 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KPRP | |
| BioGPS: 448834 | ||
| Pathway | NCI Pathway Interaction Database: KPRP | |
| KEGG: KPRP | ||
| REACTOME: KPRP | ||
| Pathway Commons: KPRP | ||
| Context | iHOP: KPRP | |
| ligand binding site mutation search in PubMed: KPRP | ||
| UCL Cancer Institute: KPRP | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of KPRP | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KPRP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 1.745488353 | -1.433286156 | 3.17877451 | 2.28E-10 | 8.29E-10 |
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| TissGene-miRNA for KPRP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KPRP |
| TissGeneSNV for KPRP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S330F | SKCM | 3 |
| p.P478T | ACC | 2 |
| p.P384L | SKCM | 2 |
| p.P344L | SKCM | 2 |
| p.E134X | COAD | 1 |
| p.P212S | LUSC | 1 |
| p.R222L | LUAD | 1 |
| p.W363* | LUAD | 1 |
| p.V128D | STAD | 1 |
| p.E123G | LGG | 1 |
| p.R248C | GBM | 1 |
| p.P229S | SKCM | 1 |
| p.A99E | LUAD | 1 |
| p.E42K | BLCA | 1 |
| p.I350M | LUAD | 1 |
| p.Q44K | LUAD | 1 |
| p.G192D | BRCA | 1 |
| p.G453W | PRAD | 1 |
| p.P257L | HNSC | 1 |
| p.R326Q | UCEC | 1 |
| p.E553D | UCEC | 1 |
| p.Q341H | LUAD | 1 |
| p.G514C | STAD | 1 |
| p.A63T | GBM | 1 |
| p.P359S | OV | 1 |
| p.F579V | BLCA | 1 |
| p.R222Q | GBM | 1 |
| p.P161S | SKCM | 1 |
| p.A365T | PRAD | 1 |
| p.V150G | LUAD | 1 |
| p.T91I | SKCM | 1 |
| p.A574T | LUAD | 1 |
| p.E493K | SKCM | 1 |
| p.Y153D | GBM | 1 |
| p.R274C | UCEC | 1 |
| p.P508T | UCS | 1 |
| p.R261L | LUAD | 1 |
| p.Q6R | SKCM | 1 |
| p.R260Q | KIRP | 1 |
| p.R425Q | SKCM | 1 |
| p.G176E | SKCM | 1 |
| p.P528S | SKCM | 1 |
| p.V154A | UCEC | 1 |
| p.Q160* | BLCA | 1 |
| p.Q103* | LUAD | 1 |
| p.E573G | STAD | 1 |
| p.R554Q | OV | 1 |
| p.C391R | LUAD | 1 |
| p.G364V | STAD | 1 |
| p.D562Y | OV | 1 |
| p.P266S | PRAD | 1 |
| p.R409H | READ | 1 |
| p.S518C | SKCM | 1 |
| p.S534I | GBM | 1 |
| p.G192S | SKCM | 1 |
| p.Q71H | READ | 1 |
| p.R177K | SKCM | 1 |
| p.Q209* | SKCM | 1 |
| p.E42X | ESCA | 1 |
| p.R386W | BLCA | 1 |
| p.G358A | LUAD | 1 |
| p.S125L | SKCM | 1 |
| p.L283M | LUAD | 1 |
| p.V374I | BRCA | 1 |
| p.Q235X | DLBC | 1 |
| p.T244N | HNSC | 1 |
| p.R254K | SKCM | 1 |
| p.S105P | BLCA | 1 |
| p.C201W | BLCA | 1 |
| p.R168H | COAD | 1 |
| p.R261Q | SKCM | 1 |
| p.R405C | STAD | 1 |
| p.E471K | BLCA | 1 |
| p.R308H | READ | 1 |
| p.G572V | LUAD | 1 |
| p.I457T | LUAD | 1 |
| p.E328K | SKCM | 1 |
| p.P257L | LUAD | 1 |
| p.Q121H | LUAD | 1 |
| p.R425* | UCS | 1 |
| p.R352C | PRAD | 1 |
| p.R405H | SARC | 1 |
| p.C413S | COAD | 1 |
| p.E526K | COAD | 1 |
| p.R555K | TGCT | 1 |
| p.Q397H | LGG | 1 |
| p.E123K | HNSC | 1 |
| p.G96C | LUSC | 1 |
| p.S115F | SKCM | 1 |
| p.P480S | SKCM | 1 |
| p.R312C | DLBC | 1 |
| p.R312C | UCEC | 1 |
| p.A527G | DLBC | 1 |
| p.C255* | KIRC | 1 |
| p.R267C | LUAD | 1 |
| p.E289* | SKCM | 1 |
| p.R10H | PAAD | 1 |
| p.S102Y | BLCA | 1 |
| p.Q181K | LUAD | 1 |
| p.Y282* | LUAD | 1 |
| p.G544D | KIRP | 1 |
| p.S576I | READ | 1 |
| p.R312C | STAD | 1 |
| p.Q185K | UCEC | 1 |
| p.R321H | UCEC | 1 |
| p.F579L | LAML | 1 |
| p.R222W | COAD | 1 |
| p.C148F | LUAD | 1 |
| p.E517K | BLCA | 1 |
| p.R475* | STAD | 1 |
| p.A50V | UCEC | 1 |
| p.282_283YL>*M | LUAD | 1 |
| p.S497C | LUAD | 1 |
| p.N152I | HNSC | 1 |
| p.C113* | LUAD | 1 |
| p.R496C | UCEC | 1 |
| p.P29H | LIHC | 1 |
| p.R267H | UCEC | 1 |
| p.L513P | COAD | 1 |
| p.P29L | HNSC | 1 |
| p.A31T | OV | 1 |
| p.P349S | SKCM | 1 |
| p.A85V | UCEC | 1 |
| p.A365T | LGG | 1 |
| p.E540K | SKCM | 1 |
| p.A574E | BRCA | 1 |
| p.E540D | BLCA | 1 |
| p.S576N | OV | 1 |
| p.R445Q | PRAD | 1 |
| p.R407H | COAD | 1 |
| p.K95E | SKCM | 1 |
| p.C255X | KIRC | 1 |
| p.S105F | SKCM | 1 |
| p.P462L | SKCM | 1 |
| p.R496H | GBM | 1 |
| p.R10C | OV | 1 |
| p.E276D | LUSC | 1 |
| p.C455S | HNSC | 1 |
| p.R224Q | UCEC | 1 |
| p.R312H | LGG | 1 |
| p.R554P | LIHC | 1 |
| p.R425X | UCS | 1 |
| p.R387H | COAD | 1 |
| p.Q75R | LIHC | 1 |
| p.S213F | SKCM | 1 |
| p.P349L | SKCM | 1 |
| p.G20S | SKCM | 1 |
| p.E116D | LUSC | 1 |
| p.P40S | SKCM | 1 |
| p.Q220* | HNSC | 1 |
| p.R451L | LIHC | 1 |
| p.R274C | UCS | 1 |
| p.R475X | STAD | 1 |
| p.S190G | ESCA | 1 |
| p.P510Q | LUAD | 1 |
| p.R445W | PAAD | 1 |
| p.Q80L | LUAD | 1 |
| p.D524G | ESCA | 1 |
| p.Y240N | LIHC | 1 |
| p.D389H | HNSC | 1 |
| p.M1V | LUSC | 1 |
| p.S366F | SKCM | 1 |
| p.L388I | STAD | 1 |
| p.Q62H | ESCA | 1 |
| p.R387H | STAD | 1 |
| p.Q14E | BLCA | 1 |
| p.R250W | LIHC | 1 |
| p.R326Q | SKCM | 1 |
| p.C455Y | LUAD | 1 |
| p.S105Y | UCEC | 1 |
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| TissGeneCNV for KPRP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KPRP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for KPRP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for KPRP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KPRP |
| TissGeneDrug for KPRP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KPRP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1832097 | EPIDERMAL DIFFERENTIATION COMPLEX | 1 | BeFree |
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