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| TissGeneSummary for MYCL |
 Gene summary |
| Basic gene information | Gene symbol | MYCL |
| Gene name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | |
| Synonyms | LMYC|MYCL1|bHLHe38 | |
| Cytomap | UCSC genome browser: 1p34.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001033081.2, NM_001033082.2,NM_005376.4, | |
| Description | class E basic helix-loop-helix protein 38l-myc-1 proto-oncogenemyc-related gene from lung cancerprotein L-Mycprotein L-Myc-1v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 164850 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000116990 | ||
| HPRD : 01279 | ||
| Vega : OTTHUMG00000009243 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MYCL | |
| BioGPS: 4610 | ||
| Pathway | NCI Pathway Interaction Database: MYCL | |
| KEGG: MYCL | ||
| REACTOME: MYCL | ||
| Pathway Commons: MYCL | ||
| Context | iHOP: MYCL | |
| ligand binding site mutation search in PubMed: MYCL | ||
| UCL Cancer Institute: MYCL | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneySkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHSKCM | |
| Reference showing the relevant tissue of MYCL | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MYCL |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for MYCL |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MYCL |
| TissGeneSNV for MYCL |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V221M | SKCM | 2 |
| p.P263S | BLCA | 1 |
| p.R387T | BLCA | 1 |
| p.R222Q | SKCM | 1 |
| p.A333G | LUAD | 1 |
| p.S140N | HNSC | 1 |
| p.R330* | KIRC | 1 |
| p.R375T | BLCA | 1 |
| p.G113V | HNSC | 1 |
| p.E256Q | HNSC | 1 |
| p.R261M | LUAD | 1 |
| p.P249L | HNSC | 1 |
| p.C98F | SKCM | 1 |
| p.R375T | LUAD | 1 |
| p.A333V | ESCA | 1 |
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| TissGeneCNV for MYCL |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MYCL |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for MYCL |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for MYCL |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MYCL |
| TissGeneDrug for MYCL |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MYCL |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0242379 | Malignant neoplasm of lung | 7 | BeFree,GAD |
| umls:C0024623 | Malignant neoplasm of stomach | 5 | BeFree,GAD |
| umls:C0684249 | Carcinoma of lung | 4 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree,GAD |
| umls:C0024121 | Lung Neoplasms | 3 | LHGDN |
| umls:C0025149 | Medulloblastoma | 3 | BeFree,CTD_human |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
| umls:C0027819 | Neuroblastoma | 3 | BeFree |
| umls:C0149925 | Small cell carcinoma of lung | 3 | BeFree,CTD_human |
| umls:C0700095 | Central neuroblastoma | 3 | BeFree |
| umls:C1527249 | Colorectal Cancer | 3 | BeFree,GAD |
| umls:C0546837 | Malignant neoplasm of esophagus | 2 | GAD |
| umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0005695 | Bladder Neoplasm | 1 | LHGDN |
| umls:C0007117 | Basal cell carcinoma | 1 | GAD |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | GAD |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
| umls:C0016059 | Fibrosis | 1 | LHGDN |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0023761 | Lip Neoplasms | 1 | GAD |
| umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| umls:C0037286 | Skin Neoplasms | 1 | GAD |
| umls:C0038356 | Stomach Neoplasms | 1 | GAD |
| umls:C0040136 | Thyroid Neoplasm | 1 | LHGDN |
| umls:C0085750 | Adenosis of Breast | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0334050 | Adenosis | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
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