 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for NRL |
 Gene summary |
| Basic gene information | Gene symbol | NRL |
| Gene name | neural retina leucine zipper | |
| Synonyms | D14S46E|NRL-MAF|RP27 | |
| Cytomap | UCSC genome browser: 14q11.1-q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006177.3, | |
| Description | neural retina-specific leucine zipper proteinneural retinal-specific leucine zipper | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 162080 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000129535 | ||
| HPRD : 08875 | ||
| Vega : OTTHUMG00000028789 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NRL | |
| BioGPS: 4901 | ||
| Pathway | NCI Pathway Interaction Database: NRL | |
| KEGG: NRL | ||
| REACTOME: NRL | ||
| Pathway Commons: NRL | ||
| Context | iHOP: NRL | |
| ligand binding site mutation search in PubMed: NRL | ||
| UCL Cancer Institute: NRL | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
| Reference showing the relevant tissue of NRL | ||
| Description by TissGene annotations | TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 8552602 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 8552602 |
| Top |
| TissGeneExp for NRL |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 0.386327802 | 1.791152802 | -1.404825 | 7.82E-32 | 1.72E-30 |
| Top |
| TissGene-miRNA for NRL |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for NRL |
| TissGeneSNV for NRL |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q100R | PCPG | 1 |
| p.Q100K | TGCT | 1 |
| p.L235V | CESC | 1 |
| p.D155H | GBM | 1 |
| p.T77I | PRAD | 1 |
| p.E22Q | LUAD | 1 |
| p.E93K | BLCA | 1 |
| p.C176F | SKCM | 1 |
| p.R164H | STAD | 1 |
| p.P104Q | LUAD | 1 |
| p.H125N | LUSC | 1 |
| p.Q79* | LUAD | 1 |
| Top |
| TissGeneCNV for NRL |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for NRL |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI861912 | EIF3H-NRL | chr8:117657177 | chr14:24584067 | |
| Chimerdb3.0 | ChiTaRs | NA | AA493380 | NRL-NRL | chr14:24571860 | chr14:24572244 | |
| Chimerdb3.0 | ChiTaRs | NA | W22249 | NRL-NRL | chr14:24553833 | chr14:24553361 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A49L-01A | NEDD8-MDP1-NRL | CDS-3'UTR | chr14:24701455 | chr14:24550777 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0EQ-01A | ACER3-NRL | CDS-5UTR | Chr11:76572123 | Chr14:24552084 |
| Top |
| TissGeneNet for NRL |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| NRL, RHO, EDF1, CRX, FIZ1 (tumor) | NRL, RHO, EDF1, CRX, FIZ1 (normal) |
 |  |
| Top |
| TissGeneProg for NRL |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for NRL |
| TissGeneDrug for NRL |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for NRL |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0339525 | Autosomal dominant retinitis pigmentosa | 9 | BeFree |
| umls:C0035334 | Retinitis Pigmentosa | 7 | BeFree,CLINVAR,CTD_human,GAD,LHGDN,ORPHANET |
| umls:C0035309 | Retinal Diseases | 4 | BeFree,GAD |
| umls:C0339526 | Autosomal recessive retinitis pigmentosa | 3 | BeFree |
| umls:C1849394 | Enhanced S-Cone Syndrome | 3 | BeFree |
| umls:C0028077 | Night Blindness | 2 | CTD_human |
| umls:C0035304 | Retinal Degeneration | 2 | BeFree,CTD_human |
| umls:C0339527 | Leber Congenital Amaurosis | 2 | BeFree |
| umls:C0854723 | Retinal Dystrophies | 2 | BeFree |
| umls:C1834329 | RETINITIS PIGMENTOSA 27 | 2 | CLINVAR,UNIPROT |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0034951 | Refractive Errors | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C1834330 | Retinal Degeneration, Autosomal Recessive, Clumped Pigment Type | 0 | CLINVAR |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |