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| TissGeneSummary for CRNN |
 Gene summary |
| Basic gene information | Gene symbol | CRNN |
| Gene name | cornulin | |
| Synonyms | C1orf10|DRC1|PDRC1|SEP53 | |
| Cytomap | UCSC genome browser: 1q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_016190.2, | |
| Description | 53 kDa putative calcium-binding protein53 kDa squamous epithelial-induced stress protein58 kDa heat shock proteinsquamous epithelial heat shock protein 53tumor-related protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611312 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000143536 | ||
| HPRD : 12720 | ||
| Vega : OTTHUMG00000012383 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CRNN | |
| BioGPS: 49860 | ||
| Pathway | NCI Pathway Interaction Database: CRNN | |
| KEGG: CRNN | ||
| REACTOME: CRNN | ||
| Pathway Commons: CRNN | ||
| Context | iHOP: CRNN | |
| ligand binding site mutation search in PubMed: CRNN | ||
| UCL Cancer Institute: CRNN | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
| Reference showing the relevant tissue of CRNN | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0009408 | response to heat | 11606197 | GO:0016337 | single organismal cell-cell adhesion | 2631556 | GO:0009408 | response to heat | 11606197 | GO:0016337 | single organismal cell-cell adhesion | 2631556 |
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| TissGeneExp for CRNN |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | 4.181512055 | 11.77581206 | -7.5943 | 1.98E-12 | 6.65E-11 |
| LUSC | -0.245013207 | -1.574224972 | 1.329211765 | 0.00208 | 0.003691221 |
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| TissGene-miRNA for CRNN |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CRNN |
| TissGeneSNV for CRNN |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q153X | SKCM | 3 |
| p.Q153* | SKCM | 3 |
| p.G116R | SKCM | 2 |
| p.R479Q | SKCM | 2 |
| p.E477* | CESC | 1 |
| p.Q249H | KICH | 1 |
| p.E197K | COAD | 1 |
| p.A287T | BLCA | 1 |
| p.Q174H | LUSC | 1 |
| p.Q374K | LUAD | 1 |
| p.S391R | PAAD | 1 |
| p.Q83E | LUAD | 1 |
| p.E441K | SKCM | 1 |
| p.R138I | UCEC | 1 |
| p.E94D | STAD | 1 |
| p.Q240R | STAD | 1 |
| p.V390E | SARC | 1 |
| p.W442L | LUAD | 1 |
| p.G103R | SKCM | 1 |
| p.D445N | HNSC | 1 |
| p.S465Y | BRCA | 1 |
| p.V282L | STAD | 1 |
| p.S447X | COAD | 1 |
| p.E56K | OV | 1 |
| p.D50N | SARC | 1 |
| p.G429E | SKCM | 1 |
| p.A162V | UCEC | 1 |
| p.Q6R | UCS | 1 |
| p.D456N | SKCM | 1 |
| p.E476K | CESC | 1 |
| p.R484K | BLCA | 1 |
| p.T379M | STAD | 1 |
| p.D456H | LIHC | 1 |
| p.S230Y | HNSC | 1 |
| p.E190K | SKCM | 1 |
| p.G237C | GBM | 1 |
| p.T232I | PAAD | 1 |
| p.Q3* | BLCA | 1 |
| p.E73G | SKCM | 1 |
| p.S186P | LUAD | 1 |
| p.G401E | LUAD | 1 |
| p.Q174* | LUSC | 1 |
| p.T21M | COAD | 1 |
| p.A82S | HNSC | 1 |
| p.E122A | UCEC | 1 |
| p.A126V | UCEC | 1 |
| p.E190Q | HNSC | 1 |
| p.A404S | LUAD | 1 |
| p.G272S | KIRC | 1 |
| p.I183M | UCEC | 1 |
| p.D62N | SKCM | 1 |
| p.S307N | STAD | 1 |
| p.A260T | LUSC | 1 |
| p.S180G | SKCM | 1 |
| p.V399L | COAD | 1 |
| p.R424H | BRCA | 1 |
| p.E115K | SKCM | 1 |
| p.G439V | COAD | 1 |
| p.A19P | LUAD | 1 |
| p.E94D | KIRC | 1 |
| p.R138K | SKCM | 1 |
| p.T239N | BRCA | 1 |
| p.E416K | BRCA | 1 |
| p.Q280K | OV | 1 |
| p.Q385* | SKCM | 1 |
| p.A408E | LUAD | 1 |
| p.P400L | GBM | 1 |
| p.E133K | SKCM | 1 |
| p.E209K | UCEC | 1 |
| p.L36P | KIRP | 1 |
| p.G95E | LUAD | 1 |
| p.H368D | LUAD | 1 |
| p.R335K | SKCM | 1 |
| p.R424H | LGG | 1 |
| p.W442L | COAD | 1 |
| p.D62V | DLBC | 1 |
| p.N7K | ESCA | 1 |
| p.G369* | LUSC | 1 |
| p.S110L | UCEC | 1 |
| p.L453F | UCEC | 1 |
| p.Q374H | DLBC | 1 |
| p.R200K | SKCM | 1 |
| p.Q264E | SARC | 1 |
| p.Q468R | COAD | 1 |
| p.R424C | STAD | 1 |
| p.N459S | UCEC | 1 |
| p.G334D | LUAD | 1 |
| p.E394G | LUAD | 1 |
| p.G407E | SKCM | 1 |
| p.P400L | PRAD | 1 |
| p.G407W | LUAD | 1 |
| p.D43E | ESCA | 1 |
| p.A126V | GBM | 1 |
| p.G334C | LIHC | 1 |
| p.G431R | SKCM | 1 |
| p.A371D | PAAD | 1 |
| p.A42V | SKCM | 1 |
| p.E13D | LUAD | 1 |
| p.G251E | SKCM | 1 |
| p.R149K | SKCM | 1 |
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| TissGeneCNV for CRNN |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CRNN |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CRNN |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CRNN, SQSTM1, WHSC1L1 (tumor) | CRNN, SQSTM1, WHSC1L1 (normal) |
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| TissGeneProg for CRNN |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CRNN |
| TissGeneDrug for CRNN |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CRNN |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 5 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 3 | BeFree,GAD |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,GAD |
| umls:C0152018 | Esophageal carcinoma | 2 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 2 | BeFree |
| umls:C0013595 | Eczema | 1 | BeFree |
| umls:C0017168 | Gastroesophageal reflux disease | 1 | BeFree |
| umls:C0022521 | Kartagener Syndrome | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C1832097 | EPIDERMAL DIFFERENTIATION COMPLEX | 1 | BeFree |
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