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| TissGeneSummary for PCDH8 |
 Gene summary |
| Basic gene information | Gene symbol | PCDH8 |
| Gene name | protocadherin 8 | |
| Synonyms | ARCADLIN|PAPC | |
| Cytomap | UCSC genome browser: 13q21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002590.3, NM_032949.2, | |
| Description | protocadherin-8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603580 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000136099 | ||
| HPRD : 04660 | ||
| Vega : OTTHUMG00000016979 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PCDH8 | |
| BioGPS: 5100 | ||
| Pathway | NCI Pathway Interaction Database: PCDH8 | |
| KEGG: PCDH8 | ||
| REACTOME: PCDH8 | ||
| Pathway Commons: PCDH8 | ||
| Context | iHOP: PCDH8 | |
| ligand binding site mutation search in PubMed: PCDH8 | ||
| UCL Cancer Institute: PCDH8 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of PCDH8 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PCDH8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -2.117085399 | -0.340346937 | -1.776738462 | 2.46E-08 | 1.97E-07 |
| STAD | -1.770521937 | -0.383825062 | -1.386696875 | 0.000524 | 0.003134245 |
| LUAD | -1.333386592 | -2.431521075 | 1.098134483 | 0.000627 | 0.001410593 |
| LUSC | -1.189164584 | -2.462095957 | 1.272931373 | 0.000373 | 0.000733621 |
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| TissGene-miRNA for PCDH8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-1271-5p | MIMAT0005796 | 0.042 | -0.28 | 56 |
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| TissGeneMut for PCDH8 |
| TissGeneSNV for PCDH8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.W7R | COAD | 2 |
| p.A877T | COAD | 2 |
| p.P1036T | LUAD | 1 |
| p.R598C | PRAD | 1 |
| p.R776C | STAD | 1 |
| p.D934G | UCEC | 1 |
| p.S72T | LIHC | 1 |
| p.A974T | STAD | 1 |
| p.R776H | STAD | 1 |
| p.A704T | PAAD | 1 |
| p.G89S | KIRP | 1 |
| p.E954V | HNSC | 1 |
| p.C11S | LUAD | 1 |
| p.K956N | CESC | 1 |
| p.M55V | BLCA | 1 |
| p.V739G | LUAD | 1 |
| p.T61K | LUSC | 1 |
| p.Q327H | LUSC | 1 |
| p.V347I | BLCA | 1 |
| p.G714D | STAD | 1 |
| p.A935T | HNSC | 1 |
| p.T466A | STAD | 1 |
| p.A881V | STAD | 1 |
| p.G1013W | UCEC | 1 |
| p.A722V | HNSC | 1 |
| p.A560V | SKCM | 1 |
| p.G971W | LUAD | 1 |
| p.A837P | PRAD | 1 |
| p.E1019Q | HNSC | 1 |
| p.R153H | COAD | 1 |
| p.S961C | LUAD | 1 |
| p.Q656L | LUAD | 1 |
| p.Q886X | SKCM | 1 |
| p.R995Q | STAD | 1 |
| p.Q602H | BLCA | 1 |
| p.M55I | BLCA | 1 |
| p.G898A | LUSC | 1 |
| p.L104M | UCEC | 1 |
| p.P100T | ACC | 1 |
| p.G47R | LIHC | 1 |
| p.R776C | BLCA | 1 |
| p.G8C | LUAD | 1 |
| p.A270G | HNSC | 1 |
| p.R729S | LUAD | 1 |
| p.M66L | LGG | 1 |
| p.R1000K | SKCM | 1 |
| p.V347F | LUAD | 1 |
| p.C760F | HNSC | 1 |
| p.G942V | SKCM | 1 |
| p.W7L | LUAD | 1 |
| p.A405E | LUAD | 1 |
| p.H611N | ACC | 1 |
| p.G1039E | SKCM | 1 |
| p.G971R | SKCM | 1 |
| p.P587S | SKCM | 1 |
| p.D87V | LUAD | 1 |
| p.A769T | STAD | 1 |
| p.A372S | HNSC | 1 |
| p.R687S | LUAD | 1 |
| p.Q1015K | LUAD | 1 |
| p.Y1004C | STAD | 1 |
| p.D328Y | LUSC | 1 |
| p.G1039V | SKCM | 1 |
| p.A953S | LUAD | 1 |
| p.G920R | SKCM | 1 |
| p.G669E | SKCM | 1 |
| p.S618Y | LUSC | 1 |
| p.G644E | HNSC | 1 |
| p.D107H | LUAD | 1 |
| p.E458K | LUAD | 1 |
| p.R478C | PAAD | 1 |
| p.R598S | LUAD | 1 |
| p.Q1045* | SKCM | 1 |
| p.G741R | STAD | 1 |
| p.V1070A | LIHC | 1 |
| p.Q983* | SKCM | 1 |
| p.W746X | SKCM | 1 |
| p.S905Y | UCS | 1 |
| p.G86R | BLCA | 1 |
| p.G147C | LUSC | 1 |
| p.E38Q | HNSC | 1 |
| p.R137S | LUAD | 1 |
| p.R33X | STAD | 1 |
| p.Q1045* | LUAD | 1 |
| p.Q1005L | LUAD | 1 |
| p.G758W | LUAD | 1 |
| p.R777H | HNSC | 1 |
| p.P511S | SKCM | 1 |
| p.R33* | STAD | 1 |
| p.G874R | SKCM | 1 |
| p.A376T | ESCA | 1 |
| p.A839V | ACC | 1 |
| p.T991M | LGG | 1 |
| p.R92H | LUAD | 1 |
| p.A444T | STAD | 1 |
| p.E78K | BLCA | 1 |
| p.T991M | ESCA | 1 |
| p.A166T | STAD | 1 |
| p.S742P | STAD | 1 |
| p.R716C | STAD | 1 |
| p.E643* | LUAD | 1 |
| p.G971E | SKCM | 1 |
| p.G683C | LUAD | 1 |
| p.Q945H | UCEC | 1 |
| p.A430T | STAD | 1 |
| p.W746* | SKCM | 1 |
| p.Y34C | COAD | 1 |
| p.P1038T | LUAD | 1 |
| p.P141Q | LUAD | 1 |
| p.A766T | STAD | 1 |
| p.R1037L | LUAD | 1 |
| p.E51K | STAD | 1 |
| p.V577I | STAD | 1 |
| p.G168E | SKCM | 1 |
| p.P511L | SKCM | 1 |
| p.R963C | LUSC | 1 |
| p.G798R | BLCA | 1 |
| p.G971V | LUAD | 1 |
| p.L677I | LIHC | 1 |
| p.D91N | SKCM | 1 |
| p.H943D | BLCA | 1 |
| p.A271T | THCA | 1 |
| p.G1057V | BLCA | 1 |
| p.Y34H | THYM | 1 |
| p.P358L | BLCA | 1 |
| p.G86R | PAAD | 1 |
| p.G874E | SKCM | 1 |
| p.G823R | SKCM | 1 |
| p.F987I | KIRP | 1 |
| p.Y1004C | UCEC | 1 |
| p.E643* | BLCA | 1 |
| p.E657K | SKCM | 1 |
| p.E728* | LUAD | 1 |
| p.G97S | SKCM | 1 |
| p.P965L | COAD | 1 |
| p.R173H | UCS | 1 |
| p.R667S | STAD | 1 |
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| TissGeneCNV for PCDH8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PCDH8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for PCDH8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| COAD (tumor) | COAD (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| KICH (tumor) | KICH (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| STAD (tumor) | STAD (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| THCA (tumor) | THCA (normal) |
| PCDH8, BTRC, UBQLN4 (tumor) | PCDH8, BTRC, UBQLN4 (normal) |
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| TissGeneProg for PCDH8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PCDH8 |
| TissGeneDrug for PCDH8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PCDH8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 2 | BeFree |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0025958 | Microcephaly | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| umls:C0036341 | Schizophrenia | 1 | BeFree,LHGDN |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
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