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| TissGeneSummary for LUZP4 |
 Gene summary |
| Basic gene information | Gene symbol | LUZP4 |
| Gene name | leucine zipper protein 4 | |
| Synonyms | CT-28|CT-8|CT28|HOM-TES-85 | |
| Cytomap | UCSC genome browser: Xq23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_016383.4, | |
| Description | HOM-TES-85 tumor antigencancer/testis antigen 28tumor antigen HOM-TES-85 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300616 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000102021 | ||
| HPRD : 06589 | ||
| Vega : OTTHUMG00000022234 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LUZP4 | |
| BioGPS: 51213 | ||
| Pathway | NCI Pathway Interaction Database: LUZP4 | |
| KEGG: LUZP4 | ||
| REACTOME: LUZP4 | ||
| Pathway Commons: LUZP4 | ||
| Context | iHOP: LUZP4 | |
| ligand binding site mutation search in PubMed: LUZP4 | ||
| UCL Cancer Institute: LUZP4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of LUZP4 | ||
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for LUZP4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for LUZP4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LUZP4 |
| TissGeneSNV for LUZP4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S101F | HNSC | 2 |
| p.R161Q | UCEC | 2 |
| p.V281M | GBM | 1 |
| p.P15S | COAD | 1 |
| p.Q179H | LUAD | 1 |
| p.R161* | STAD | 1 |
| p.E202Q | LUAD | 1 |
| p.S305* | BLCA | 1 |
| p.P143T | UCEC | 1 |
| p.E133D | LUAD | 1 |
| p.G141E | SKCM | 1 |
| p.G86E | SKCM | 1 |
| p.T269I | PRAD | 1 |
| p.Q109X | STAD | 1 |
| p.E133Q | HNSC | 1 |
| p.S169Y | UCEC | 1 |
| p.R71C | STAD | 1 |
| p.H17Y | SKCM | 1 |
| p.R51I | LIHC | 1 |
| p.T255N | LUSC | 1 |
| p.R73Q | LUAD | 1 |
| p.S3L | SKCM | 1 |
| p.P14L | STAD | 1 |
| p.R168G | HNSC | 1 |
| p.S77* | BLCA | 1 |
| p.R163* | STAD | 1 |
| p.D31Y | OV | 1 |
| p.L259R | UCEC | 1 |
| p.E115* | HNSC | 1 |
| p.R161X | STAD | 1 |
| p.R5W | UCEC | 1 |
| p.G236X | STAD | 1 |
| p.N53S | BRCA | 1 |
| p.R71H | UCEC | 1 |
| p.K257R | KIRC | 1 |
| p.R233C | SARC | 1 |
| p.Q109* | STAD | 1 |
| p.R71H | COAD | 1 |
| p.R264K | SKCM | 1 |
| p.S176F | UCEC | 1 |
| p.A123V | UCEC | 1 |
| p.E85K | SKCM | 1 |
| p.Q94L | OV | 1 |
| p.E284Q | BRCA | 1 |
| p.S197F | LUAD | 1 |
| p.E133Q | ACC | 1 |
| p.G236A | UCEC | 1 |
| p.Q263R | LIHC | 1 |
| p.R168K | SKCM | 1 |
| p.E58K | SKCM | 1 |
| p.P96L | STAD | 1 |
| p.R163* | UCEC | 1 |
| p.R71C | SKCM | 1 |
| p.H17Y | BRCA | 1 |
| p.N142K | STAD | 1 |
| p.V281M | LGG | 1 |
| p.L2P | UCS | 1 |
| p.S59L | COAD | 1 |
| p.G86R | SKCM | 1 |
| p.E76* | UCEC | 1 |
| p.G236* | STAD | 1 |
| p.E38K | SKCM | 1 |
| p.R163X | STAD | 1 |
| p.K127R | LIHC | 1 |
| p.G41E | SKCM | 1 |
| p.R224K | SKCM | 1 |
| p.R161* | LUAD | 1 |
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| TissGeneCNV for LUZP4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LUZP4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for LUZP4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for LUZP4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LUZP4 |
| TissGeneDrug for LUZP4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LUZP4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0030491 | Parapsoriasis | 1 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
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