 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for DUOX1 |
 Gene summary |
| Basic gene information | Gene symbol | DUOX1 |
| Gene name | dual oxidase 1 | |
| Synonyms | LNOX1|NOXEF1|THOX1 | |
| Cytomap | UCSC genome browser: 15q15.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_017434.4, NM_175940.2, | |
| Description | NADPH thyroid oxidase 1flavoprotein NADPH oxidaselarge NOX 1long NOX 1nicotinamide adenine dinucleotide phosphate oxidasethyroid oxidase 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606758 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000137857 | ||
| HPRD : 08421 | ||
| Vega : OTTHUMG00000171987 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DUOX1 | |
| BioGPS: 53905 | ||
| Pathway | NCI Pathway Interaction Database: DUOX1 | |
| KEGG: DUOX1 | ||
| REACTOME: DUOX1 | ||
| Pathway Commons: DUOX1 | ||
| Context | iHOP: DUOX1 | |
| ligand binding site mutation search in PubMed: DUOX1 | ||
| UCL Cancer Institute: DUOX1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCATHCA | |
| Reference showing the relevant tissue of DUOX1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0019221 | cytokine-mediated signaling pathway | 16111680 | GO:0051591 | response to cAMP | 15062544 | GO:0019221 | cytokine-mediated signaling pathway | 16111680 | GO:0051591 | response to cAMP | 15062544 |
| Top |
| TissGeneExp for DUOX1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | -0.067994813 | 2.167622495 | -2.235617308 | 2.00E-11 | 5.75E-10 |
| LUAD | 0.975028397 | 4.783228397 | -3.8082 | 2.65E-20 | 5.72E-19 |
| LUSC | 2.266927585 | 4.680337389 | -2.413409804 | 2.22E-14 | 1.24E-13 |
| HNSC | 3.708676833 | 4.727595438 | -1.018918605 | 0.00183 | 0.00571875 |
| LIHC | -2.910767121 | -3.931455121 | 1.020688 | 0.000444 | 0.001307857 |
| Top |
| TissGene-miRNA for DUOX1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-338-3p | MIMAT0000763 | 0.048 | -0.27 | 56 |
| Top |
| TissGeneMut for DUOX1 |
| TissGeneSNV for DUOX1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V501I | CESC | 3 |
| p.R509W | STAD | 2 |
| p.E503D | CESC | 2 |
| p.C1026R | COAD | 1 |
| p.P312S | STAD | 1 |
| p.L1468M | PAAD | 1 |
| p.V501I | STAD | 1 |
| p.Q328R | UCEC | 1 |
| p.E379K | SKCM | 1 |
| p.L361F | CESC | 1 |
| p.G1340W | LGG | 1 |
| p.F807Y | SKCM | 1 |
| p.N728Y | SKCM | 1 |
| p.R17K | SKCM | 1 |
| p.G485E | HNSC | 1 |
| p.E1530K | SARC | 1 |
| p.L1364M | UCEC | 1 |
| p.V1139I | COAD | 1 |
| p.V1448M | PRAD | 1 |
| p.R163Q | DLBC | 1 |
| p.F102V | SKCM | 1 |
| p.G410R | SKCM | 1 |
| p.Q1411E | LUAD | 1 |
| p.P335S | COAD | 1 |
| p.D782N | HNSC | 1 |
| p.R1337Q | SKCM | 1 |
| p.R395Q | UCEC | 1 |
| p.I178V | LIHC | 1 |
| p.S975R | LUSC | 1 |
| p.A894T | BRCA | 1 |
| p.A1070T | COAD | 1 |
| p.Y1052C | UCEC | 1 |
| p.M1467V | HNSC | 1 |
| p.R1106H | STAD | 1 |
| p.Q1293K | LUAD | 1 |
| p.P268A | BRCA | 1 |
| p.G1516R | READ | 1 |
| p.N74S | SKCM | 1 |
| p.S26L | UCEC | 1 |
| p.K734M | BRCA | 1 |
| p.L1313V | BRCA | 1 |
| p.R585H | COAD | 1 |
| p.R1513W | COAD | 1 |
| p.A1070T | ESCA | 1 |
| p.A222T | SARC | 1 |
| p.R265H | UCEC | 1 |
| p.T1423M | PAAD | 1 |
| p.T536I | SKCM | 1 |
| p.G1261E | SKCM | 1 |
| p.V1081M | UCEC | 1 |
| p.P297R | ESCA | 1 |
| p.R31Q | HNSC | 1 |
| p.S83* | LUAD | 1 |
| p.V1050M | STAD | 1 |
| p.A60V | LGG | 1 |
| p.R1495L | KIRP | 1 |
| p.R679H | STAD | 1 |
| p.A87V | COAD | 1 |
| p.R669H | COAD | 1 |
| p.F1321C | HNSC | 1 |
| p.G1057R | SKCM | 1 |
| p.G20_splice | LUSC | 1 |
| p.H1212Q | BRCA | 1 |
| p.E371K | SKCM | 1 |
| p.F1208C | STAD | 1 |
| p.D462N | SKCM | 1 |
| p.I962M | BLCA | 1 |
| p.R1113L | ESCA | 1 |
| p.G1262V | PAAD | 1 |
| p.W436* | CESC | 1 |
| p.R1043H | PAAD | 1 |
| p.Q1375L | KIRC | 1 |
| p.I1470T | SARC | 1 |
| p.E1348Q | BLCA | 1 |
| p.F205I | SKCM | 1 |
| p.P581L | SKCM | 1 |
| p.S694F | HNSC | 1 |
| p.A753S | HNSC | 1 |
| p.R722W | LIHC | 1 |
| p.P212L | SARC | 1 |
| p.E488K | SKCM | 1 |
| p.T1073M | BRCA | 1 |
| p.R838X | DLBC | 1 |
| p.R533* | PAAD | 1 |
| p.R513H | STAD | 1 |
| p.F1419L | UCEC | 1 |
| p.R1042L | LUSC | 1 |
| p.A1532V | LGG | 1 |
| p.V616F | HNSC | 1 |
| p.E1016K | CESC | 1 |
| p.R1337W | SKCM | 1 |
| p.V106M | PRAD | 1 |
| p.Q1476R | LUSC | 1 |
| p.T463I | PAAD | 1 |
| p.Y1206* | OV | 1 |
| p.S358F | UCEC | 1 |
| p.C890S | LIHC | 1 |
| p.D919N | READ | 1 |
| p.Q65* | SKCM | 1 |
| p.E517K | KIRC | 1 |
| p.Q1029K | LUAD | 1 |
| p.T1393I | UCEC | 1 |
| p.F1218L | PAAD | 1 |
| p.D874Y | LGG | 1 |
| p.I318V | KIRC | 1 |
| p.G249C | UCEC | 1 |
| p.S882F | SKCM | 1 |
| p.R513C | COAD | 1 |
| p.R746Q | PAAD | 1 |
| p.P297R | SKCM | 1 |
| p.R1541W | PRAD | 1 |
| p.E1459K | UCS | 1 |
| p.V338I | STAD | 1 |
| p.V845L | STAD | 1 |
| p.P297R | LUSC | 1 |
| p.V1127M | STAD | 1 |
| p.E765D | UCEC | 1 |
| p.R353Q | SARC | 1 |
| p.D397N | SKCM | 1 |
| p.R148K | SKCM | 1 |
| p.D586N | KIRC | 1 |
| p.M751K | LIHC | 1 |
| p.R31Q | CESC | 1 |
| p.R76* | HNSC | 1 |
| p.Y587C | LUAD | 1 |
| p.G494E | SKCM | 1 |
| p.F767L | SKCM | 1 |
| p.D1174N | HNSC | 1 |
| p.R971C | UCEC | 1 |
| p.R1337Q | STAD | 1 |
| p.R416H | SKCM | 1 |
| p.R1481Q | STAD | 1 |
| p.R952Q | STAD | 1 |
| p.R1357I | UCEC | 1 |
| p.R952Q | UCEC | 1 |
| p.A218V | PRAD | 1 |
| p.A6T | LUAD | 1 |
| p.S1086L | UCEC | 1 |
| p.Y1099* | HNSC | 1 |
| p.L1163I | UCEC | 1 |
| p.L1268Q | ACC | 1 |
| Top |
| TissGeneCNV for DUOX1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for DUOX1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-IG-A6QS-01A | DUOX1-COL17A1 | Out-of-Frame | chr15:45430212 | chr10:105799398 |
| Top |
| TissGeneNet for DUOX1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| DUOX1, TXNDC11, TPO (tumor) | DUOX1, TXNDC11, TPO (normal) |
 |  |
| Top |
| TissGeneProg for DUOX1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for DUOX1 |
| TissGeneDrug for DUOX1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for DUOX1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0018203 | Chronic granulomatous disease | 8 | BeFree |
| umls:C0010308 | Congenital Hypothyroidism | 3 | BeFree |
| umls:C0342200 | Endemic Cretinism | 3 | BeFree |
| umls:C0018801 | Heart failure | 2 | BeFree |
| umls:C0018802 | Congestive heart failure | 2 | BeFree |
| umls:C0019693 | HIV Infections | 2 | BeFree,GAD |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0011603 | Dermatitis | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | BeFree |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | GAD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | BeFree,LHGDN |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0026946 | Mycoses | 1 | BeFree |
| umls:C0037284 | Skin lesion | 1 | BeFree |
| umls:C0040136 | Thyroid Neoplasm | 1 | BeFree |
| umls:C0151650 | Renal fibrosis | 1 | BeFree |
| umls:C0206682 | Follicular thyroid carcinoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0271829 | Pendred's syndrome | 1 | BeFree |
| umls:C0600452 | Hepatopulmonary Syndrome | 1 | GAD |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0730605 | Moderate chronic obstructive pulmonary disease | 1 | BeFree |
| umls:C0751967 | Multiple Sclerosis, Relapsing-Remitting | 1 | BeFree |
| umls:C0856169 | Endothelial dysfunction | 1 | BeFree |
| umls:C0917996 | Cerebral Aneurysm | 1 | BeFree |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C1290884 | Inflammatory disorder | 1 | BeFree |
| umls:C1518296 | Neuropathogenesis | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |