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| TissGeneSummary for UGT1A4 |
 Gene summary |
| Basic gene information | Gene symbol | UGT1A4 |
| Gene name | UDP glucuronosyltransferase 1 family, polypeptide A4 | |
| Synonyms | HUG-BR2|UDPGT|UDPGT 1-4|UGT-1D|UGT1-04|UGT1.4|UGT1D | |
| Cytomap | UCSC genome browser: 2q37 | |
| Type of gene | protein-coding | |
| RefGenes | NM_007120.2, | |
| Description | UDP glycosyltransferase 1 family, polypeptide A4UDP-glucuronosyltransferase 1-4UDP-glucuronosyltransferase 1-DUDP-glucuronosyltransferase 1A4bilirubin UDP-glucuronosyltransferase isozyme 2bilirubin-specific UDPGT isozyme 2 | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 606429 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000244474 | ||
| HPRD : 08402 | ||
| Vega : OTTHUMG00000059119 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_UGT1A4 | |
| BioGPS: 54657 | ||
| Pathway | NCI Pathway Interaction Database: UGT1A4 | |
| KEGG: UGT1A4 | ||
| REACTOME: UGT1A4 | ||
| Pathway Commons: UGT1A4 | ||
| Context | iHOP: UGT1A4 | |
| ligand binding site mutation search in PubMed: UGT1A4 | ||
| UCL Cancer Institute: UGT1A4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCTGCT | |
| Reference showing the relevant tissue of UGT1A4 | ||
| Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0052695 | cellular glucuronidation | 22579593 | GO:0052695 | cellular glucuronidation | 22579593 |
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| TissGeneExp for UGT1A4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 8.737380414 | 11.45699041 | -2.71961 | 2.06E-06 | 1.02E-05 |
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| TissGene-miRNA for UGT1A4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-141-3p | MIMAT0000432 | 0.025 | -0.26 | 78 |
| ACC | hsa-miR-141-3p | MIMAT0000432 | 0.025 | -0.26 | 78 |
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| TissGeneMut for UGT1A4 |
| TissGeneSNV for UGT1A4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E88K | SKCM | 3 |
| p.F74I | STAD | 1 |
| p.R337W | UCEC | 1 |
| p.V254L | LUAD | 1 |
| p.R3* | SKCM | 1 |
| p.E237D | SARC | 1 |
| p.V154I | COAD | 1 |
| p.T199M | ESCA | 1 |
| p.P230L | LUAD | 1 |
| p.G494C | OV | 1 |
| p.A472T | UCEC | 1 |
| p.M273T | SKCM | 1 |
| p.W84* | SKCM | 1 |
| p.V92I | BRCA | 1 |
| p.Y231C | LIHC | 1 |
| p.R112T | ESCA | 1 |
| p.L218V | COAD | 1 |
| p.P266T | THYM | 1 |
| p.F227V | STAD | 1 |
| p.A162T | SKCM | 1 |
| p.M205I | SKCM | 1 |
| p.P268T | KIRC | 1 |
| p.S253C | HNSC | 1 |
| p.V154F | PAAD | 1 |
| p.K285* | LUAD | 1 |
| p.R258Q | UCEC | 1 |
| p.K30N | HNSC | 1 |
| p.M44I | UCEC | 1 |
| p.A159V | PAAD | 1 |
| p.A58V | PAAD | 1 |
| p.P177S | COAD | 1 |
| p.G278D | SKCM | 1 |
| p.R11Q | LGG | 1 |
| p.L218V | BLCA | 1 |
| p.M442I | BRCA | 1 |
| p.G259E | SKCM | 1 |
| p.R3X | SKCM | 1 |
| p.Y164H | BRCA | 1 |
| p.V149I | OV | 1 |
| p.G55V | LUAD | 1 |
| p.P40H | THCA | 1 |
| p.L165M | UCEC | 1 |
| p.T93M | SARC | 1 |
| p.R258L | SKCM | 1 |
| p.P153R | KIRP | 1 |
| p.L156F | SKCM | 1 |
| p.Q240E | CESC | 1 |
| p.R45W | STAD | 1 |
| p.L17P | KIRC | 1 |
| p.A136V | STAD | 1 |
| p.S111F | SKCM | 1 |
| p.S39N | STAD | 1 |
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| TissGeneCNV for UGT1A4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for UGT1A4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-91-6836-01A | DGKD-UGT1A4 | In-Frame | chr2:234263320 | chr2:234675679 |
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| TissGeneNet for UGT1A4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| COAD (tumor) | COAD (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| KICH (tumor) | KICH (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| STAD (tumor) | STAD (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| THCA (tumor) | THCA (normal) |
| UGT1A4, CYB5A (tumor) | UGT1A4, CYB5A (normal) |
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| TissGeneProg for UGT1A4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for UGT1A4 |
| TissGeneDrug for UGT1A4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for UGT1A4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010324 | Crigler Najjar syndrome, type 1 | 8 | BeFree,UNIPROT |
| umls:C0014544 | Epilepsy | 4 | BeFree |
| umls:C0020433 | Hyperbilirubinemia | 4 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | GAD |
| umls:C2931132 | Crigler Najjar syndrome, type 2 | 2 | UNIPROT |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0011053 | Deafness | 1 | GAD |
| umls:C0011226 | Hepatitis D Infection | 1 | BeFree |
| umls:C0013291 | Duodenal Neoplasms | 1 | GAD |
| umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | GAD |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | GAD |
| umls:C0345904 | Malignant neoplasm of liver | 1 | GAD |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C1384666 | hearing impairment | 1 | GAD |
| umls:C3887873 | Hearing Loss | 1 | GAD |
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