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| TissGeneSummary for CCDC91 |
 Gene summary |
| Basic gene information | Gene symbol | CCDC91 |
| Gene name | coiled-coil domain containing 91 | |
| Synonyms | p56 | |
| Cytomap | UCSC genome browser: 12p11.22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_018318.3, | |
| Description | GGA binding partnerGGA-binding partnercoiled-coil domain-containing protein 91p56 accessory protein | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000123106 | ||
| HPRD : 16905 | ||
| Vega : OTTHUMG00000169141 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CCDC91 | |
| BioGPS: 55297 | ||
| Pathway | NCI Pathway Interaction Database: CCDC91 | |
| KEGG: CCDC91 | ||
| REACTOME: CCDC91 | ||
| Pathway Commons: CCDC91 | ||
| Context | iHOP: CCDC91 | |
| ligand binding site mutation search in PubMed: CCDC91 | ||
| UCL Cancer Institute: CCDC91 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCATGCT | |
| Reference showing the relevant tissue of CCDC91 | ||
| Description by TissGene annotations | TissgsLTS Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CCDC91 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for CCDC91 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CCDC91 |
| TissGeneSNV for CCDC91 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G172V | SARC | 2 |
| p.S238C | LGG | 1 |
| p.E164K | SKCM | 1 |
| p.E48D | LUAD | 1 |
| p.K177R | BLCA | 1 |
| p.S238F | LUSC | 1 |
| p.T25A | UCEC | 1 |
| p.E241Q | CESC | 1 |
| p.A239T | UCEC | 1 |
| p.T369N | UCEC | 1 |
| p.L145I | HNSC | 1 |
| p.T435K | HNSC | 1 |
| p.T369N | PAAD | 1 |
| p.E72G | BLCA | 1 |
| p.E294D | STAD | 1 |
| p.E289K | COAD | 1 |
| p.Q91* | CESC | 1 |
| p.D201Y | LUSC | 1 |
| p.G206D | UCEC | 1 |
| p.S69L | LUAD | 1 |
| p.D347Y | LGG | 1 |
| p.K111R | LIHC | 1 |
| p.E386Q | LUAD | 1 |
| p.Q367H | ACC | 1 |
| p.N328D | STAD | 1 |
| p.C247Y | LUAD | 1 |
| p.A332V | UCEC | 1 |
| p.E48* | LUAD | 1 |
| p.A332V | READ | 1 |
| p.V438I | UCEC | 1 |
| p.S64C | HNSC | 1 |
| p.A12V | COAD | 1 |
| p.I182T | KIRC | 1 |
| p.Q256H | BRCA | 1 |
| p.N131I | SARC | 1 |
| p.A36T | COAD | 1 |
| p.P104L | SKCM | 1 |
| p.E21* | CESC | 1 |
| p.S281T | STAD | 1 |
| p.G172D | SKCM | 1 |
| p.G17D | ESCA | 1 |
| p.G18E | SKCM | 1 |
| p.R298I | COAD | 1 |
| p.A77S | PRAD | 1 |
| p.E149* | LUAD | 1 |
| p.F421L | HNSC | 1 |
| p.K137R | LUAD | 1 |
| p.A276S | LUAD | 1 |
| p.K111R | HNSC | 1 |
| p.A76G | LUSC | 1 |
| p.Q91P | BRCA | 1 |
| p.Q353* | CESC | 1 |
| p.V119M | GBM | 1 |
| p.G60V | THYM | 1 |
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| TissGeneCNV for CCDC91 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CCDC91 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BQ318634 | HSP90AA1-CCDC91 | chr14:102551729 | chr12:28603291 | |
| Chimerdb3.0 | ChiTaRs | NA | AW897460 | CCDC91-FRY | chr12:28702997 | chr13:32794482 | |
| Chimerdb3.0 | ChiTaRs | NA | BF921132 | PCDH9-CCDC91 | chr13:67559923 | chr12:28702312 | |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AO-A0JC-01A | PPP2R2B-CCDC91 | In-Frame | chr5:146257564 | chr12:28544236 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-IG-A4QS-01A | PARP8-CCDC91 | Out-of-Frame | chr5:49963959 | chr12:28603093 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A1AH-01A | CCDC91-LYRM5 | In-frame | Chr12:28544344 | Chr12:25357025 |
| TCGAfusionPortal | PRADA | LGG | TCGA-HT-7873-01B | CCDC91-FAR2 | CDS-5UTR | Chr12:28412375 | Chr12:29423345 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-05-4415-01A | CCDC91-NTSR1 | In-frame | Chr12:28544344 | Chr20:61386037 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-22-4595-01A | CCDC91-PDZRN4 | In-frame | Chr12:28637098 | Chr12:41900258 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-KK-A8ID-01A | BICD1-CCDC91 | In-frame | Chr12:32260478 | Chr12:28603094 |
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| TissGeneNet for CCDC91 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| COAD (tumor) | COAD (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| KICH (tumor) | KICH (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| STAD (tumor) | STAD (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| THCA (tumor) | THCA (normal) |
| CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (tumor) | CCDC91, GGA1, EWSR1, TESC, GGA2, SYNRG (normal) |
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| TissGeneProg for CCDC91 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CCDC91 |
| TissGeneDrug for CCDC91 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CCDC91 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027092 | Myopia | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0206633 | Angiomyolipoma | 1 | BeFree |
| umls:C0236969 | Substance-Related Disorders | 1 | CTD_human |
| umls:C1865343 | OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT OF SPINE | 1 | GWASCAT |
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